Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137382409> ?p ?o ?g. }
- W3137382409 endingPage "324" @default.
- W3137382409 startingPage "313" @default.
- W3137382409 abstract "Focal adhesion kinase (FAK) is both a non-receptor tyrosine kinase and an adaptor protein that primarily regulates adhesion signalling and cell migration, but FAK can also promote cell survival in response to stress. FAK is commonly overexpressed in cancer and is considered a high-value druggable target, with multiple FAK inhibitors currently in development. Evidence suggests that in the clinical setting, FAK targeting will be most effective in combination with other agents so as to reverse failure of chemotherapies or targeted therapies and enhance efficacy of immune-based treatments of solid tumours. Here, we discuss the recent preclinical evidence that implicates FAK in anticancer therapeutic resistance, leading to the view that FAK inhibitors will have their greatest utility as combination therapies in selected patient populations. Focal adhesion kinase (FAK) is overexpressed in many cancers and is involved in a multitude of oncogenic processes and resistance mechanisms. This Review discusses the rationale and preclinical evidence for FAK-based combination therapies and strategies for future development." @default.
- W3137382409 created "2021-03-29" @default.
- W3137382409 creator A5001264667 @default.
- W3137382409 creator A5016618033 @default.
- W3137382409 creator A5052539061 @default.
- W3137382409 creator A5057799963 @default.
- W3137382409 creator A5090973852 @default.
- W3137382409 date "2021-03-17" @default.
- W3137382409 modified "2023-10-16" @default.
- W3137382409 title "Targeting FAK in anticancer combination therapies" @default.
- W3137382409 cites W1529313052 @default.
- W3137382409 cites W1695398347 @default.
- W3137382409 cites W1811064827 @default.
- W3137382409 cites W1902804987 @default.
- W3137382409 cites W1904209158 @default.
- W3137382409 cites W1941703300 @default.
- W3137382409 cites W1964020745 @default.
- W3137382409 cites W1965491861 @default.
- W3137382409 cites W1973767497 @default.
- W3137382409 cites W1975473523 @default.
- W3137382409 cites W1987278872 @default.
- W3137382409 cites W1988810895 @default.
- W3137382409 cites W1989270381 @default.
- W3137382409 cites W1995835059 @default.
- W3137382409 cites W1999084733 @default.
- W3137382409 cites W2001587874 @default.
- W3137382409 cites W2004976275 @default.
- W3137382409 cites W2006121655 @default.
- W3137382409 cites W2006892275 @default.
- W3137382409 cites W2012347139 @default.
- W3137382409 cites W2016512775 @default.
- W3137382409 cites W2022207080 @default.
- W3137382409 cites W2025018535 @default.
- W3137382409 cites W2026542427 @default.
- W3137382409 cites W2032211985 @default.
- W3137382409 cites W2043117244 @default.
- W3137382409 cites W2044423100 @default.
- W3137382409 cites W2048117957 @default.
- W3137382409 cites W2049432379 @default.
- W3137382409 cites W2058149485 @default.
- W3137382409 cites W2059407064 @default.
- W3137382409 cites W2063284791 @default.
- W3137382409 cites W2065088072 @default.
- W3137382409 cites W2074070818 @default.
- W3137382409 cites W2079015343 @default.
- W3137382409 cites W2087013294 @default.
- W3137382409 cites W2091506455 @default.
- W3137382409 cites W2091972503 @default.
- W3137382409 cites W2098373319 @default.
- W3137382409 cites W2100641053 @default.
- W3137382409 cites W2100796422 @default.
- W3137382409 cites W2101025132 @default.
- W3137382409 cites W2102498455 @default.
- W3137382409 cites W2111130664 @default.
- W3137382409 cites W2113551776 @default.
- W3137382409 cites W2118440955 @default.
- W3137382409 cites W2121220704 @default.
- W3137382409 cites W2121290668 @default.
- W3137382409 cites W2123696077 @default.
- W3137382409 cites W2124373629 @default.
- W3137382409 cites W2126893023 @default.
- W3137382409 cites W2128542677 @default.
- W3137382409 cites W2128554762 @default.
- W3137382409 cites W2143391840 @default.
- W3137382409 cites W2148107330 @default.
- W3137382409 cites W2148512375 @default.
- W3137382409 cites W2152869165 @default.
- W3137382409 cites W2155158934 @default.
- W3137382409 cites W2158769524 @default.
- W3137382409 cites W2164953703 @default.
- W3137382409 cites W2197806847 @default.
- W3137382409 cites W2258963753 @default.
- W3137382409 cites W2298480233 @default.
- W3137382409 cites W2300471130 @default.
- W3137382409 cites W2314423784 @default.
- W3137382409 cites W2333587048 @default.
- W3137382409 cites W2337683177 @default.
- W3137382409 cites W2403308793 @default.
- W3137382409 cites W2410074823 @default.
- W3137382409 cites W2426003472 @default.
- W3137382409 cites W2469223980 @default.
- W3137382409 cites W2513362995 @default.
- W3137382409 cites W2528438395 @default.
- W3137382409 cites W2556570155 @default.
- W3137382409 cites W2569342357 @default.
- W3137382409 cites W2587048937 @default.
- W3137382409 cites W2589037042 @default.
- W3137382409 cites W2603092809 @default.
- W3137382409 cites W2603962019 @default.
- W3137382409 cites W2605233023 @default.
- W3137382409 cites W2605955768 @default.
- W3137382409 cites W2613629789 @default.
- W3137382409 cites W2626577233 @default.
- W3137382409 cites W2735027468 @default.
- W3137382409 cites W2737071436 @default.
- W3137382409 cites W2764321027 @default.
- W3137382409 cites W2768887441 @default.
- W3137382409 cites W2773242491 @default.