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- W3137382546 abstract "Depression affects more than 400 million people worldwide. Treatment options are partially effective and the exact pathomechanism of depression is unclear. Recently, clinical observations have demonstrated that treatment with RAAS inhibitors is related to the mitigation of symptoms in patients with depression. It has been proven that apart from systemic renin-angiotensin-aldosterone system (RAAS), a local independent RAAS exists in the brain. Hyperactivation of brain RAAS leads to cognitive decline and development of depression partly via induction of neuroinflammation. Decreased brain-derived neurotrophic factor (BDNF) level—as a result of inflammatory processes—contributes to the development of depression. Studies indicate that the antidepressant effect of RAAS blockers is connected to reduced inflammation and enhanced expression of neurotrophins. Based on these findings, RAAS inhibitors are potential agents for treating per se mood disorders or associated with hypertension, diabetes, or other chronic diseases." @default.
- W3137382546 created "2021-03-29" @default.
- W3137382546 creator A5039142882 @default.
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- W3137382546 date "2021-01-01" @default.
- W3137382546 modified "2023-09-24" @default.
- W3137382546 title "Angiotensin receptor 1 blockade as an antidepression strategy" @default.
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- W3137382546 doi "https://doi.org/10.1016/b978-0-12-817933-8.00003-7" @default.
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