Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137384170> ?p ?o ?g. }
- W3137384170 endingPage "90" @default.
- W3137384170 startingPage "76" @default.
- W3137384170 abstract "Open globe trauma is the major cause for single eye blindness that stem from subsequent proliferative vitreoretinopathy (PVR). Though biomaterials and tissue engineering have significantly advanced drug delivery and management of human diseases, currently there is no effective drug formulation or device to pharmacologically mitigate PVR formation after open-globe eye trauma. This highlighted the challenge we are facing to bring the technology from bench to bedside. The current study reported an engineered episcleral drug film using biodegradable material, Poly(L-lactide)-co-poly(ɛ-caprolactone), and triamcinolone acetonide (TA) as a model drug. The film can be conveniently sized into any shape to fit the configuration of the eye globe trauma and easily installed onto the ruptured sclera during primary trauma repair surgery. The film allows therapeutic TA to slow release for at least 6 months without toxicity and demonstrated a significant benefit to reduce the odds of developing severe PVR by 5.7 times when compared with a no-drug film control on a rabbit trauma PVR model. Our results suggested this micro episcleral drug film as promising drug delivery carrier for the targeted treatment of various unwanted retinal proliferation diseases." @default.
- W3137384170 created "2021-03-29" @default.
- W3137384170 creator A5022681943 @default.
- W3137384170 creator A5037567485 @default.
- W3137384170 creator A5039407742 @default.
- W3137384170 creator A5039896971 @default.
- W3137384170 creator A5043099393 @default.
- W3137384170 creator A5063447635 @default.
- W3137384170 creator A5066204165 @default.
- W3137384170 creator A5076805184 @default.
- W3137384170 date "2021-05-01" @default.
- W3137384170 modified "2023-09-29" @default.
- W3137384170 title "Controlled release of triamcinolone from an episcleral micro film delivery system for open-globe eye injuries and proliferative vitreoretinopathy" @default.
- W3137384170 cites W1503939339 @default.
- W3137384170 cites W1548538594 @default.
- W3137384170 cites W1581527645 @default.
- W3137384170 cites W1963589138 @default.
- W3137384170 cites W1971483854 @default.
- W3137384170 cites W1973406141 @default.
- W3137384170 cites W1973571228 @default.
- W3137384170 cites W1974780687 @default.
- W3137384170 cites W1976626911 @default.
- W3137384170 cites W1982095171 @default.
- W3137384170 cites W1984871917 @default.
- W3137384170 cites W1994389095 @default.
- W3137384170 cites W1994673609 @default.
- W3137384170 cites W2005272995 @default.
- W3137384170 cites W2006082798 @default.
- W3137384170 cites W2013228856 @default.
- W3137384170 cites W2015929381 @default.
- W3137384170 cites W2020467906 @default.
- W3137384170 cites W2023301647 @default.
- W3137384170 cites W2025450854 @default.
- W3137384170 cites W2028925055 @default.
- W3137384170 cites W2032605474 @default.
- W3137384170 cites W2046723774 @default.
- W3137384170 cites W2046934244 @default.
- W3137384170 cites W2047322445 @default.
- W3137384170 cites W2055370551 @default.
- W3137384170 cites W2056192765 @default.
- W3137384170 cites W2056970085 @default.
- W3137384170 cites W2058913110 @default.
- W3137384170 cites W2080786018 @default.
- W3137384170 cites W2084710939 @default.
- W3137384170 cites W2087032263 @default.
- W3137384170 cites W2104662204 @default.
- W3137384170 cites W2112691507 @default.
- W3137384170 cites W2116522674 @default.
- W3137384170 cites W2122538859 @default.
- W3137384170 cites W2125770993 @default.
- W3137384170 cites W2129457141 @default.
- W3137384170 cites W2130337409 @default.
- W3137384170 cites W2158269015 @default.
- W3137384170 cites W2159823236 @default.
- W3137384170 cites W2171994576 @default.
- W3137384170 cites W2318378557 @default.
- W3137384170 cites W2323699130 @default.
- W3137384170 cites W2596129276 @default.
- W3137384170 cites W2772525036 @default.
- W3137384170 cites W2773576558 @default.
- W3137384170 cites W2891215467 @default.
- W3137384170 cites W315858785 @default.
- W3137384170 cites W4229823998 @default.
- W3137384170 cites W4251960546 @default.
- W3137384170 cites W772139783 @default.
- W3137384170 doi "https://doi.org/10.1016/j.jconrel.2021.03.023" @default.
- W3137384170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33771623" @default.
- W3137384170 hasPublicationYear "2021" @default.
- W3137384170 type Work @default.
- W3137384170 sameAs 3137384170 @default.
- W3137384170 citedByCount "4" @default.
- W3137384170 countsByYear W31373841702022 @default.
- W3137384170 countsByYear W31373841702023 @default.
- W3137384170 crossrefType "journal-article" @default.
- W3137384170 hasAuthorship W3137384170A5022681943 @default.
- W3137384170 hasAuthorship W3137384170A5037567485 @default.
- W3137384170 hasAuthorship W3137384170A5039407742 @default.
- W3137384170 hasAuthorship W3137384170A5039896971 @default.
- W3137384170 hasAuthorship W3137384170A5043099393 @default.
- W3137384170 hasAuthorship W3137384170A5063447635 @default.
- W3137384170 hasAuthorship W3137384170A5066204165 @default.
- W3137384170 hasAuthorship W3137384170A5076805184 @default.
- W3137384170 hasConcept C118487528 @default.
- W3137384170 hasConcept C141071460 @default.
- W3137384170 hasConcept C171250308 @default.
- W3137384170 hasConcept C192562407 @default.
- W3137384170 hasConcept C2777100477 @default.
- W3137384170 hasConcept C2778903070 @default.
- W3137384170 hasConcept C2779059073 @default.
- W3137384170 hasConcept C2779820397 @default.
- W3137384170 hasConcept C2780428090 @default.
- W3137384170 hasConcept C2780827179 @default.
- W3137384170 hasConcept C71924100 @default.
- W3137384170 hasConceptScore W3137384170C118487528 @default.
- W3137384170 hasConceptScore W3137384170C141071460 @default.
- W3137384170 hasConceptScore W3137384170C171250308 @default.
- W3137384170 hasConceptScore W3137384170C192562407 @default.
- W3137384170 hasConceptScore W3137384170C2777100477 @default.