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- W3137389936 abstract "Diabetes doubles the risk of VCID but underlying reasons remain unclear. We reported that diabetic animals are more prone to microemboli (ME)-mediated tissue damage/demyelination and progressive cognitive decline. The goal of the current study was to determine the temporal and spatial changes in cerebral blood flow (CBF) and brain structure after ME injection using MRI. At 10 weeks after onset of diabetes, control and diabetic rats received cholesterol crystal ME (40-70 μm) injection. MRI scans were performed at baseline, weeks 8 and 12 post-ME. Behavioral tests including novel object recognition (NOR) and Y-maze for cognitive function and gait analysis with CatWalk were conducted at same time points as well as week 16. Diabetic animals had baseline deficits in certain cognitive domains and progressively worsened. ME injection caused infarction in two of the diabetic animals (n=6) but were not detected in controls (n=8). Diffusion Tensor Imaging (DTI) metrics showed lower axial diffusivity (DA) in the cortex of diabetic animals, indicating a degree of axonal damage. Post ME, radial diffusivity (DR) was increased while fractional anisotropy (FA) was decreased in the cortex at week 12. At the dorsal hippocampus, mean (MD), DA and DR were all significantly increased by week 12. These changes may reflect loss of tissue integrity and edema in the cortex and loss of axons and myelin damage in the hippocampus of diabetic animals after ME injection. Diabetic animals also showed a significant increase of CBF at week 8 particularly at the dorsal hippocampus and thalamus, which returned to normal by week 12. These results suggest that ME injury and associated cognitive deficits are greater in diabetes, which also causes cerebrovascular dysfunction, and strategies to improve vascular function can be a preventive and therapeutic strategy for VCID." @default.
- W3137389936 created "2021-03-29" @default.
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- W3137389936 date "2021-03-01" @default.
- W3137389936 modified "2023-09-23" @default.
- W3137389936 title "Abstract P739: Magnetic Resonance Imaging-Based Comparison of Temporal Changes in Brain Microstructure After Microemboli Injection in Control and Diabetic Rats: Relevance to Vascular Cognitive Impairment/Dementia" @default.
- W3137389936 doi "https://doi.org/10.1161/str.52.suppl_1.p739" @default.
- W3137389936 hasPublicationYear "2021" @default.
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