FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137391586> ?p ?o ?g. }

• W3137391586 endingPage "634" @default.
• W3137391586 startingPage "634" @default.
• W3137391586 abstract "Prostaglandin E1 (PGE1) exerts various pharmacological effects such as membrane stabilization, anti-inflammatory functions, vasodilation, and platelet aggregation inhibition. We have previously demonstrated that PGE1 has a beneficial impact on patients suffering from intracerebral hemorrhage (ICH). The related mechanism underlying PGE1's beneficial effect on ICH treatment needs further exploration.The present study elucidates the mechanism of PGE1 on ICH treatment using a neuronal apoptosis model in vitro. The mouse primary cortical neurons were pretreated with different concentrations of PGE1, followed by the treatment with hemin, the main catabolite in whole blood, to mimic the clinical ICH.Comparing with the vehicle-treated group, PGE1 prevented cultured cortical neurons from the accumulation of inhibited intracellular levels of reactive oxygen species (ROS), amelioration of mitochondrial membrane potential, and hemin-induced apoptosis. The reduction of ROS and apoptosis were associated with the up-regulation of Heme oxygenase-1 (HO-1) expression. Knockdown of nuclear transcription factor erythroid 2-related factor (Nrf2) by siRNA attenuated the upregulation of HO-1 as well as the protective effect of PGE1.Our work suggests that the Nrf2/HO-1 molecular pathway may play a crucial role in treating ICH patients with PGE1 and may represent novel molecular targets, resulting in discovering new drugs for ICH treatment." @default.
• W3137391586 created "2021-03-29" @default.
• W3137391586 creator A5005748869 @default.
• W3137391586 creator A5016887957 @default.
• W3137391586 creator A5017944089 @default.
• W3137391586 creator A5027291735 @default.
• W3137391586 creator A5028915287 @default.
• W3137391586 creator A5031279704 @default.
• W3137391586 creator A5038698547 @default.
• W3137391586 creator A5040558103 @default.
• W3137391586 creator A5071745025 @default.
• W3137391586 date "2021-04-01" @default.
• W3137391586 modified "2023-10-03" @default.
• W3137391586 title "PGE1 triggers Nrf2/HO-1 signal pathway to resist hemin-induced toxicity in mouse cortical neurons" @default.
• W3137391586 cites W1505624094 @default.
• W3137391586 cites W1968967111 @default.
• W3137391586 cites W1971156281 @default.
• W3137391586 cites W1975895958 @default.
• W3137391586 cites W1981282646 @default.
• W3137391586 cites W1999240677 @default.
• W3137391586 cites W2000487621 @default.
• W3137391586 cites W2016681275 @default.
• W3137391586 cites W2047230924 @default.
• W3137391586 cites W2054329933 @default.
• W3137391586 cites W2080111717 @default.
• W3137391586 cites W2081727947 @default.
• W3137391586 cites W2084773420 @default.
• W3137391586 cites W2085974262 @default.
• W3137391586 cites W2088267242 @default.
• W3137391586 cites W2136587148 @default.
• W3137391586 cites W2142511211 @default.
• W3137391586 cites W2143203101 @default.
• W3137391586 cites W2144350053 @default.
• W3137391586 cites W2274460090 @default.
• W3137391586 cites W2301106165 @default.
• W3137391586 cites W2343363847 @default.
• W3137391586 cites W2475113336 @default.
• W3137391586 cites W2485521328 @default.
• W3137391586 cites W2515033104 @default.
• W3137391586 cites W2590261679 @default.
• W3137391586 cites W2595455629 @default.
• W3137391586 cites W2598585593 @default.
• W3137391586 cites W2605631009 @default.
• W3137391586 cites W2607094496 @default.
• W3137391586 cites W2747710696 @default.
• W3137391586 cites W2765492912 @default.
• W3137391586 cites W2792176663 @default.
• W3137391586 cites W2894364978 @default.
• W3137391586 cites W2903210098 @default.
• W3137391586 cites W2908242818 @default.
• W3137391586 cites W2914358761 @default.
• W3137391586 cites W2915732108 @default.
• W3137391586 cites W2935926710 @default.
• W3137391586 cites W2938746902 @default.
• W3137391586 cites W2938895274 @default.
• W3137391586 cites W2947280173 @default.
• W3137391586 cites W2949558502 @default.
• W3137391586 cites W2979913054 @default.
• W3137391586 cites W2946968191 @default.
• W3137391586 doi "https://doi.org/10.21037/atm-20-5839" @default.
• W3137391586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8106031" @default.
• W3137391586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33987332" @default.
• W3137391586 hasPublicationYear "2021" @default.
• W3137391586 type Work @default.
• W3137391586 sameAs 3137391586 @default.
• W3137391586 citedByCount "3" @default.
• W3137391586 countsByYear W31373915862022 @default.
• W3137391586 crossrefType "journal-article" @default.
• W3137391586 hasAuthorship W3137391586A5005748869 @default.
• W3137391586 hasAuthorship W3137391586A5016887957 @default.
• W3137391586 hasAuthorship W3137391586A5017944089 @default.
• W3137391586 hasAuthorship W3137391586A5027291735 @default.
• W3137391586 hasAuthorship W3137391586A5028915287 @default.
• W3137391586 hasAuthorship W3137391586A5031279704 @default.
• W3137391586 hasAuthorship W3137391586A5038698547 @default.
• W3137391586 hasAuthorship W3137391586A5040558103 @default.
• W3137391586 hasAuthorship W3137391586A5071745025 @default.
• W3137391586 hasBestOaLocation W31373915861 @default.
• W3137391586 hasConcept C104317684 @default.
• W3137391586 hasConcept C127561419 @default.
• W3137391586 hasConcept C173396325 @default.
• W3137391586 hasConcept C181199279 @default.
• W3137391586 hasConcept C185592680 @default.
• W3137391586 hasConcept C190283241 @default.
• W3137391586 hasConcept C2776217839 @default.
• W3137391586 hasConcept C2777723881 @default.
• W3137391586 hasConcept C48349386 @default.
• W3137391586 hasConcept C55493867 @default.
• W3137391586 hasConcept C62478195 @default.
• W3137391586 hasConcept C79879829 @default.
• W3137391586 hasConcept C86803240 @default.
• W3137391586 hasConcept C95444343 @default.
• W3137391586 hasConcept C98274493 @default.
• W3137391586 hasConceptScore W3137391586C104317684 @default.
• W3137391586 hasConceptScore W3137391586C127561419 @default.
• W3137391586 hasConceptScore W3137391586C173396325 @default.
• W3137391586 hasConceptScore W3137391586C181199279 @default.
• W3137391586 hasConceptScore W3137391586C185592680 @default.

• next