FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137391978> ?p ?o ?g. }

• W3137391978 abstract "Management of pediatric post-transplantation lymphoproliferative disorder (PTLD) after hematopoietic stem cell (HSCT) and solid organ transplantation (SOT) is challenging.This study of 34 PTLD patients up to 19-years old diagnosed in Austria from 2000 to 2018 aimed at assessing initial characteristics, therapy, response, and outcome as well as prognostic markers of this rare pediatric disease.A retrospective data analysis was performed. Types of allografts were kidney (n = 12), liver (n = 7), heart (n = 5), hematopoietic stem cells (n = 4), lungs (n = 2), multi-visceral (n = 2), small intestine (n = 1), and vessels (n = 1). Eighteen/34 were classified as monomorphic PTLD, with DLBCL accounting for 15 cases. Polymorphic disease occurred in nine, and non-destructive lesions in six cases. One patient had a non-classifiable PTLD. Thirteen/34 patients are surviving event-free in first remission (non-destructive, n = 4/6; polymorphic, n = 4/9; monomorphic, n = 6/18). Fourteen/34 patients lacked complete response to first-line therapy, of whom seven died. Four/34 patients relapsed, of whom two died. In 3/34 patients, death occurred as a first event. The 5-year overall and event-free survival rates were 64% ± 9% and 35% ± 9% for the whole cohort. Among all parameters analyzed, only malignant disease as the indication for transplantation had a significantly poor influence on survival.This study shows PTLD still to be a major cause of mortality following SOT or HSCT in children. A continued understanding of the molecular biology of the disease shall allow to decrease treatment intensity for lower risk patients and to identify patients who may benefit from newer therapy approaches to improve outcome and decrease morbidity." @default.
• W3137391978 created "2021-03-29" @default.
• W3137391978 creator A5007033764 @default.
• W3137391978 creator A5012198373 @default.
• W3137391978 creator A5014175225 @default.
• W3137391978 creator A5015761988 @default.
• W3137391978 creator A5030425172 @default.
• W3137391978 creator A5042644667 @default.
• W3137391978 creator A5048783582 @default.
• W3137391978 creator A5049788029 @default.
• W3137391978 creator A5051115313 @default.
• W3137391978 creator A5052816766 @default.
• W3137391978 creator A5055036012 @default.
• W3137391978 creator A5059496734 @default.
• W3137391978 creator A5062188329 @default.
• W3137391978 creator A5066166272 @default.
• W3137391978 creator A5080373154 @default.
• W3137391978 creator A5085514170 @default.
• W3137391978 creator A5087860986 @default.
• W3137391978 date "2021-03-23" @default.
• W3137391978 modified "2023-10-18" @default.
• W3137391978 title "Characteristics, management, and outcome of pediatric patients with post‐transplant lymphoproliferative disease—A 20 years' experience from Austria" @default.
• W3137391978 cites W1518299472 @default.
• W3137391978 cites W1544269146 @default.
• W3137391978 cites W1572459595 @default.
• W3137391978 cites W1598609271 @default.
• W3137391978 cites W1619817984 @default.
• W3137391978 cites W1696276358 @default.
• W3137391978 cites W1779668 @default.
• W3137391978 cites W1912697366 @default.
• W3137391978 cites W1925602349 @default.
• W3137391978 cites W1964480575 @default.
• W3137391978 cites W1965069903 @default.
• W3137391978 cites W1966288055 @default.
• W3137391978 cites W1968111008 @default.
• W3137391978 cites W1968505092 @default.
• W3137391978 cites W1971278669 @default.
• W3137391978 cites W1977930329 @default.
• W3137391978 cites W1989390667 @default.
• W3137391978 cites W1999503037 @default.
• W3137391978 cites W2007263770 @default.
• W3137391978 cites W2011262362 @default.
• W3137391978 cites W2014443493 @default.
• W3137391978 cites W2015965040 @default.
• W3137391978 cites W2025833405 @default.
• W3137391978 cites W2031832264 @default.
• W3137391978 cites W2048483415 @default.
• W3137391978 cites W2053737559 @default.
• W3137391978 cites W2054279695 @default.
• W3137391978 cites W2059316119 @default.
• W3137391978 cites W2060853845 @default.
• W3137391978 cites W2061253664 @default.
• W3137391978 cites W2064873408 @default.
• W3137391978 cites W2071480334 @default.
• W3137391978 cites W2084653699 @default.
• W3137391978 cites W2094150097 @default.
• W3137391978 cites W2094352696 @default.
• W3137391978 cites W2101588170 @default.
• W3137391978 cites W2120511768 @default.
• W3137391978 cites W2125231116 @default.
• W3137391978 cites W2134766521 @default.
• W3137391978 cites W2139241553 @default.
• W3137391978 cites W2143068491 @default.
• W3137391978 cites W2151093173 @default.
• W3137391978 cites W2151139118 @default.
• W3137391978 cites W2156914816 @default.
• W3137391978 cites W2156997556 @default.
• W3137391978 cites W2164615990 @default.
• W3137391978 cites W2168740454 @default.
• W3137391978 cites W2170308172 @default.
• W3137391978 cites W2171321148 @default.
• W3137391978 cites W2310716991 @default.
• W3137391978 cites W2326233113 @default.
• W3137391978 cites W2405476713 @default.
• W3137391978 cites W2417396511 @default.
• W3137391978 cites W2514573464 @default.
• W3137391978 cites W2522939951 @default.
• W3137391978 cites W2578876390 @default.
• W3137391978 cites W2580333712 @default.
• W3137391978 cites W2625007906 @default.
• W3137391978 cites W2760098462 @default.
• W3137391978 cites W2786571997 @default.
• W3137391978 cites W2801400541 @default.
• W3137391978 cites W2803112647 @default.
• W3137391978 cites W2919736364 @default.
• W3137391978 cites W2921779622 @default.
• W3137391978 cites W2950049436 @default.
• W3137391978 cites W3004468739 @default.
• W3137391978 cites W3007978394 @default.
• W3137391978 cites W3137391978 @default.
• W3137391978 cites W4205736005 @default.
• W3137391978 cites W4253113947 @default.
• W3137391978 cites W46796727 @default.
• W3137391978 cites W71303928 @default.
• W3137391978 doi "https://doi.org/10.1002/cnr2.1375" @default.
• W3137391978 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8551996" @default.
• W3137391978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33755341" @default.
• W3137391978 hasPublicationYear "2021" @default.
• W3137391978 type Work @default.
• W3137391978 sameAs 3137391978 @default.

• next