FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137436769> ?p ?o ?g. }

• W3137436769 endingPage "249" @default.
• W3137436769 startingPage "238" @default.
• W3137436769 abstract "Herpes simplex virus-1 (HSV-1) infection leads to varying pathologies including the development of ocular lesions, stromal keratitis and encephalitis. While the role for host immunity in disease progression is well understood, the contribution of genetic variances in generating preferential viral entry receptor usage and resulting immunopathogenesis in humans are not known.Ocular cultures were obtained from patients presenting distinct pathologies of herpes simplex keratitis (HSK). Next-generation sequencing and subsequent analysis characterized genetic variances among the strains and estimated evolutionary divergence. Murine model of ocular infection was used to assess phenotypic contributions of strain variances on damage to the ocular surface and propagation of innate immunity. Flow cytometry of eye tissue identified differential recruitment of immune cell populations, cytokine array probed for programming of local immune response in the draining lymph node and histology was used to assess inflammation of the trigeminal ganglion (TG). Ex-vivo corneal cultures and in-vitro studies elucidated the role of genetic variances in altering host-pathogen interactions, leading to divergent host responses.Phylogenetic analysis of the clinical isolates suggests evolutionary divergence among currently circulating HSV-1 strains. Mutations causing alterations in functional host interactions were identified, particularly in viral entry glycoproteins which generated a receptor bias to herpesvirus entry mediator, an immune modulator involved in immunopathogenic diseases like HSK, leading to exacerbated ocular surface pathologies and heightened viral burden in the TG and brainstem.Our data suggests receptor bias resulting from genetic variances in clinical strains may dictate disease severity and treatment outcome." @default.
• W3137436769 created "2021-03-29" @default.
• W3137436769 creator A5017680561 @default.
• W3137436769 creator A5027530662 @default.
• W3137436769 creator A5032024231 @default.
• W3137436769 creator A5041837926 @default.
• W3137436769 creator A5042265507 @default.
• W3137436769 creator A5068075547 @default.
• W3137436769 creator A5069367788 @default.
• W3137436769 creator A5076097951 @default.
• W3137436769 creator A5080702571 @default.
• W3137436769 creator A5081932918 @default.
• W3137436769 creator A5083909766 @default.
• W3137436769 date "2021-07-01" @default.
• W3137436769 modified "2023-10-17" @default.
• W3137436769 title "Entry receptor bias in evolutionarily distant HSV-1 clinical strains drives divergent ocular and nervous system pathologies" @default.
• W3137436769 cites W1494969135 @default.
• W3137436769 cites W1584286177 @default.
• W3137436769 cites W1645084893 @default.
• W3137436769 cites W1773015384 @default.
• W3137436769 cites W1902745641 @default.
• W3137436769 cites W191335833 @default.
• W3137436769 cites W1920308589 @default.
• W3137436769 cites W1978117087 @default.
• W3137436769 cites W1980946147 @default.
• W3137436769 cites W1994392229 @default.
• W3137436769 cites W1995459626 @default.
• W3137436769 cites W1997733193 @default.
• W3137436769 cites W2001371234 @default.
• W3137436769 cites W2006415604 @default.
• W3137436769 cites W2009962397 @default.
• W3137436769 cites W2013243191 @default.
• W3137436769 cites W2030471534 @default.
• W3137436769 cites W2039482556 @default.
• W3137436769 cites W2065463433 @default.
• W3137436769 cites W2074948044 @default.
• W3137436769 cites W2082081016 @default.
• W3137436769 cites W2082959860 @default.
• W3137436769 cites W2088688381 @default.
• W3137436769 cites W2095840406 @default.
• W3137436769 cites W2096942445 @default.
• W3137436769 cites W2100837670 @default.
• W3137436769 cites W2113600043 @default.
• W3137436769 cites W2115374657 @default.
• W3137436769 cites W2117230571 @default.
• W3137436769 cites W2118256528 @default.
• W3137436769 cites W2132120901 @default.
• W3137436769 cites W2142293654 @default.
• W3137436769 cites W2144064375 @default.
• W3137436769 cites W2149227633 @default.
• W3137436769 cites W2151275811 @default.
• W3137436769 cites W2167990276 @default.
• W3137436769 cites W2168367540 @default.
• W3137436769 cites W2186245672 @default.
• W3137436769 cites W2226439333 @default.
• W3137436769 cites W2291409506 @default.
• W3137436769 cites W2296214831 @default.
• W3137436769 cites W2314887601 @default.
• W3137436769 cites W2316304289 @default.
• W3137436769 cites W2509312791 @default.
• W3137436769 cites W2605224490 @default.
• W3137436769 cites W2735625888 @default.
• W3137436769 cites W2765793845 @default.
• W3137436769 cites W2897491969 @default.
• W3137436769 cites W2897637939 @default.
• W3137436769 cites W2924346474 @default.
• W3137436769 cites W2944317349 @default.
• W3137436769 cites W2972480210 @default.
• W3137436769 cites W2990863023 @default.
• W3137436769 cites W3030147202 @default.
• W3137436769 cites W3043999969 @default.
• W3137436769 cites W3094921999 @default.
• W3137436769 cites W3118627743 @default.
• W3137436769 cites W3130015824 @default.
• W3137436769 cites W4229510242 @default.
• W3137436769 cites W3104651931 @default.
• W3137436769 doi "https://doi.org/10.1016/j.jtos.2021.03.005" @default.
• W3137436769 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8328871" @default.
• W3137436769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33766740" @default.
• W3137436769 hasPublicationYear "2021" @default.
• W3137436769 type Work @default.
• W3137436769 sameAs 3137436769 @default.
• W3137436769 citedByCount "6" @default.
• W3137436769 countsByYear W31374367692021 @default.
• W3137436769 countsByYear W31374367692022 @default.
• W3137436769 countsByYear W31374367692023 @default.
• W3137436769 crossrefType "journal-article" @default.
• W3137436769 hasAuthorship W3137436769A5017680561 @default.
• W3137436769 hasAuthorship W3137436769A5027530662 @default.
• W3137436769 hasAuthorship W3137436769A5032024231 @default.
• W3137436769 hasAuthorship W3137436769A5041837926 @default.
• W3137436769 hasAuthorship W3137436769A5042265507 @default.
• W3137436769 hasAuthorship W3137436769A5068075547 @default.
• W3137436769 hasAuthorship W3137436769A5069367788 @default.
• W3137436769 hasAuthorship W3137436769A5076097951 @default.
• W3137436769 hasAuthorship W3137436769A5080702571 @default.
• W3137436769 hasAuthorship W3137436769A5081932918 @default.
• W3137436769 hasAuthorship W3137436769A5083909766 @default.

• next