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• W3137454022 endingPage "213" @default.
• W3137454022 startingPage "206" @default.
• W3137454022 abstract "Genetic testing for cardiovascular (CV) disease has had a profound impact on the diagnosis and evaluation of monogenic causes of CV disease, such as hypertrophic and familial cardiomyopathies, long QT syndrome, and familial hypercholesterolemia. The success in genetic testing for monogenic diseases has prompted special interest in utilizing genetic information in the risk assessment of more common diseases such as atherosclerotic cardiovascular disease (ASCVD). Polygenic risk scores (PRS) have been developed to assess the risk of coronary artery disease, which now include millions of single-nucleotide polymorphisms that have been identified through genomewide association studies. Although these PRS have demonstrated a strong association with coronary artery disease in large cross-sectional population studies, there remains intense debate regarding the added value that PRS contributes to existing clinical risk prediction models such as the pooled cohort equations. In this review, we provide a brief background of genetic testing for monogenic drivers of CV disease and then focus on the recent developments in genetic risk assessment of ASCVD, including the use of PRS. We outline the genetic testing that is currently available to all cardiologists in the clinic and discuss the evolving sphere of specialized cardiovascular genetics programs that integrate the expertise of cardiologists, geneticists, and genetic counselors. Finally, we review the possible implications that PRS and pharmacogenomic data may soon have on clinical practice in the care for patients with or at risk of developing ASCVD." @default.
• W3137454022 created "2021-03-29" @default.
• W3137454022 creator A5022981444 @default.
• W3137454022 creator A5037310566 @default.
• W3137454022 creator A5051984028 @default.
• W3137454022 creator A5067762267 @default.
• W3137454022 date "2021-03-19" @default.
• W3137454022 modified "2023-10-18" @default.
• W3137454022 title "Genetic Risk Assessment for Atherosclerotic Cardiovascular Disease: A Guide for the General Cardiologist" @default.
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