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- W3137482340 endingPage "108888" @default.
- W3137482340 startingPage "108888" @default.
- W3137482340 abstract "During development, progenitors often differentiate many cell generations after receiving signals. These delays must be robust yet tunable for precise population size control. Polycomb repressive mechanisms, involving histone H3 lysine-27 trimethylation (H3K27me3), restrain the expression of lineage-specifying genes in progenitors and may delay their activation and ensuing differentiation. Here, we elucidate an epigenetic switch controlling the T cell commitment gene Bcl11b that holds its locus in a heritable inactive state for multiple cell generations before activation. Integrating experiments and modeling, we identify a mechanism where H3K27me3 levels at Bcl11b, regulated by methyltransferase and demethylase activities, set the time delay at which the locus switches from a compacted, silent state to an extended, active state. This activation delay robustly spans many cell generations, is tunable by chromatin modifiers and transcription factors, and is independent of cell division. With their regulatory flexibility, such timed epigenetic switches may broadly control timing in development." @default.
- W3137482340 created "2021-03-29" @default.
- W3137482340 creator A5007033351 @default.
- W3137482340 creator A5041697858 @default.
- W3137482340 creator A5044246011 @default.
- W3137482340 creator A5062568556 @default.
- W3137482340 creator A5067844977 @default.
- W3137482340 creator A5069375397 @default.
- W3137482340 creator A5079150594 @default.
- W3137482340 date "2021-03-01" @default.
- W3137482340 modified "2023-10-15" @default.
- W3137482340 title "Tunable, division-independent control of gene activation timing by a polycomb switch" @default.
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