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• W3137484795 abstract "The field of Cardio-oncology is rapidly growing with significant advances in research leading to better understanding of the underlying pathogenesis with implications in the diagnosis and management of cancer-related cardiomyopathy. Parallel to advancement in cardio-oncology is an increased awareness of the incidence of congestive heart failure and cardiomyopathy associated with malignancy. While specific cardiotoxic profiles exist for certain chemotherapeutic agents, there is increasing evidence of unexpected cardiotoxic side effects of some therapeutic modalities, combination chemo- and radiotherapy with large analyses identifying a strong association between malignancy and Takotsubo cardiomyopathy. Takotsubo Cardiomyopathy, also known as “broken-heart” syndrome or stress cardiomyopathy, is characterized by transient and reversible, regional or global, myocardial dysfunction without inciting ischemic perfusion defect from obstructive coronary artery disease. While direct causative pathophysiologic mechanisms continue to be investigated, much of the postulated pathways center on the high emotional and physical burdens of cancer and the related emotional stress associated with the diagnosis of cancer as well as the corporal effects of anti-neoplastic therapies, radiation, and oncologic surgery. In this manuscript we review the most current data in this rapidly emerging field highlighting the epidemiology, the postulated pathogenetic mechanisms as well as the current guidelines by major societies addressing malignancy -associated heart failure and cardiomyopathy, a rather complex disease entity with high morbidity and mortality." @default.
• W3137484795 created "2021-03-29" @default.
• W3137484795 creator A5001661007 @default.
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• W3137484795 date "2020-12-18" @default.
• W3137484795 modified "2023-10-16" @default.
• W3137484795 title "Heart Failure and Malignancy: Implications of Chemotherapy and Radiation in the Pathogenesis of Cardiomyopathy in Cancer Treated Populations" @default.
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• W3137484795 doi "https://doi.org/10.19080/jocct.2020.16.555944" @default.
• W3137484795 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7963216" @default.
• W3137484795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33733022" @default.
• W3137484795 hasPublicationYear "2020" @default.

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