Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137497916> ?p ?o ?g. }
- W3137497916 endingPage "237" @default.
- W3137497916 startingPage "219" @default.
- W3137497916 abstract "Extensive work has characterized endoplasmic reticulum (ER) and mitochondrial stress responses. In contrast, very little has been published about stress responses in lysosomes; subcellular acidic organelles that are physiologically important and are of pathological relevance. The greater lysosomal system is dynamic and is comprised of endosomes, lysosomes, multivesicular bodies, autophagosomes, and autophagolysosomes. They are important regulators of cellular physiology, they represent about 5% of the total cellular volume, they are heterogeneous in their sizes and distribution patterns, they are electron dense, and their subcellular positioning within cells varies in response to stimuli, insults and pH. These organelles are also integral to the pathogenesis of lysosomal storage diseases and it is increasingly recognized that lysosomes play important roles in the pathogenesis of such diverse conditions as neurodegenerative disorders and cancer. The purpose of this review is to focus attention on lysosomal stress responses (LSR), compare LSR with better characterized stress responses in ER and mitochondria, and form a framework for future characterizations of LSR. We synthesized data into the concept of LSR and present it here such that the definition of LSR can be modified as new knowledge is added and specific therapeutics are developed." @default.
- W3137497916 created "2021-03-29" @default.
- W3137497916 creator A5012132969 @default.
- W3137497916 creator A5018795768 @default.
- W3137497916 creator A5019838789 @default.
- W3137497916 creator A5053933435 @default.
- W3137497916 date "2021-03-22" @default.
- W3137497916 modified "2023-10-17" @default.
- W3137497916 title "Lysosomal Stress Response (LSR): Physiological Importance and Pathological Relevance" @default.
- W3137497916 cites W1499820592 @default.
- W3137497916 cites W1509542786 @default.
- W3137497916 cites W1511199818 @default.
- W3137497916 cites W1550693054 @default.
- W3137497916 cites W1550967330 @default.
- W3137497916 cites W1551381188 @default.
- W3137497916 cites W1597721823 @default.
- W3137497916 cites W1607224521 @default.
- W3137497916 cites W162579416 @default.
- W3137497916 cites W1643149493 @default.
- W3137497916 cites W1803199265 @default.
- W3137497916 cites W1912428744 @default.
- W3137497916 cites W1932475171 @default.
- W3137497916 cites W1953311373 @default.
- W3137497916 cites W1965350402 @default.
- W3137497916 cites W1967383774 @default.
- W3137497916 cites W1970661950 @default.
- W3137497916 cites W1974682327 @default.
- W3137497916 cites W1974804448 @default.
- W3137497916 cites W1975200363 @default.
- W3137497916 cites W1976599392 @default.
- W3137497916 cites W1977257524 @default.
- W3137497916 cites W1982498393 @default.
- W3137497916 cites W1984841297 @default.
- W3137497916 cites W1988022242 @default.
- W3137497916 cites W1988482079 @default.
- W3137497916 cites W1990895399 @default.
- W3137497916 cites W1991621909 @default.
- W3137497916 cites W1991999080 @default.
- W3137497916 cites W1996098098 @default.
- W3137497916 cites W2000678720 @default.
- W3137497916 cites W2001410779 @default.
- W3137497916 cites W2002646402 @default.
- W3137497916 cites W2003562213 @default.
- W3137497916 cites W2003708432 @default.
- W3137497916 cites W2005069707 @default.
- W3137497916 cites W2005144914 @default.
- W3137497916 cites W2009787733 @default.
- W3137497916 cites W2013262011 @default.
- W3137497916 cites W2015177326 @default.
- W3137497916 cites W2015858661 @default.
- W3137497916 cites W2016894006 @default.
- W3137497916 cites W2017196579 @default.
- W3137497916 cites W2018804582 @default.
- W3137497916 cites W2019926561 @default.
- W3137497916 cites W2020437934 @default.
- W3137497916 cites W2025257765 @default.
- W3137497916 cites W2025521110 @default.
- W3137497916 cites W2025714022 @default.
- W3137497916 cites W2031095496 @default.
- W3137497916 cites W2033620883 @default.
- W3137497916 cites W2033758935 @default.
- W3137497916 cites W2035863659 @default.
- W3137497916 cites W2042710439 @default.
- W3137497916 cites W2046250764 @default.
- W3137497916 cites W2046293048 @default.
- W3137497916 cites W2051534134 @default.
- W3137497916 cites W2053728050 @default.
- W3137497916 cites W2054595666 @default.
- W3137497916 cites W2059150576 @default.
- W3137497916 cites W2060602529 @default.
- W3137497916 cites W2069274491 @default.
- W3137497916 cites W2070163884 @default.
- W3137497916 cites W2070658923 @default.
- W3137497916 cites W2071273959 @default.
- W3137497916 cites W2071744873 @default.
- W3137497916 cites W2072247427 @default.
- W3137497916 cites W2077499130 @default.
- W3137497916 cites W2078184757 @default.
- W3137497916 cites W2080637633 @default.
- W3137497916 cites W2080983287 @default.
- W3137497916 cites W2082403287 @default.
- W3137497916 cites W2084754412 @default.
- W3137497916 cites W2090653741 @default.
- W3137497916 cites W2091017147 @default.
- W3137497916 cites W2095346330 @default.
- W3137497916 cites W2095894333 @default.
- W3137497916 cites W2096415971 @default.
- W3137497916 cites W2097939652 @default.
- W3137497916 cites W2101944374 @default.
- W3137497916 cites W2102186047 @default.
- W3137497916 cites W2103377481 @default.
- W3137497916 cites W2103516315 @default.
- W3137497916 cites W2106078939 @default.
- W3137497916 cites W2106749088 @default.
- W3137497916 cites W2106771547 @default.
- W3137497916 cites W2107441390 @default.
- W3137497916 cites W2108471384 @default.
- W3137497916 cites W2108738634 @default.