Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137520281> ?p ?o ?g. }
- W3137520281 endingPage "100060" @default.
- W3137520281 startingPage "100060" @default.
- W3137520281 abstract "Familial hypercholesterolemia (FH), an autosomal dominant disorder of LDL metabolism that is characterized by elevated LDL-cholesterol, is commonly encountered in patients with atherosclerotic coronary heart disease. Combinations of cholesterol-lowering therapies are often used to lower LDL-cholesterol in patients with FH; however, current treatment goals for LDL-cholesterol are rarely achieved in patients with homozygous FH (HoFH) and are difficult to achieve in patients with heterozygous FH (HeFH). Therapies that lower LDL-cholesterol through LDL receptor-mediated mechanisms have thus far been largely ineffective in patients with HoFH, particularly in those with negligible (<2%) LDL receptor activity. Among patients with HeFH who were at very high risk for atherosclerotic cardiovascular disease events, combined therapy consisting of a high dose of high-intensity statin, ezetimibe, and proprotein convertase subtilisin Kexin type 9 inhibitor failed to lower LDL-cholesterol to minimal acceptable goals in more than 50%. This article provides a framework for the use of available and emerging treatments that lower LDL-cholesterol in adult patients with HoFH and HeFH. A framework is provided for the use of angiopoietin-like protein 3 inhibitors in the treatment of HoFH and HeFH." @default.
- W3137520281 created "2021-03-29" @default.
- W3137520281 creator A5060465607 @default.
- W3137520281 date "2021-01-01" @default.
- W3137520281 modified "2023-09-30" @default.
- W3137520281 title "Existing and emerging therapies for the treatment of familial hypercholesterolemia" @default.
- W3137520281 cites W1543117447 @default.
- W3137520281 cites W1844854928 @default.
- W3137520281 cites W1999183747 @default.
- W3137520281 cites W2001328643 @default.
- W3137520281 cites W2011279900 @default.
- W3137520281 cites W2023735564 @default.
- W3137520281 cites W2024930123 @default.
- W3137520281 cites W2026205222 @default.
- W3137520281 cites W2069925045 @default.
- W3137520281 cites W2102238081 @default.
- W3137520281 cites W2103334195 @default.
- W3137520281 cites W2104299102 @default.
- W3137520281 cites W2142627469 @default.
- W3137520281 cites W2165624352 @default.
- W3137520281 cites W2165791625 @default.
- W3137520281 cites W2200285648 @default.
- W3137520281 cites W2304142550 @default.
- W3137520281 cites W2356448283 @default.
- W3137520281 cites W2405171365 @default.
- W3137520281 cites W2519618401 @default.
- W3137520281 cites W2519905430 @default.
- W3137520281 cites W2572244914 @default.
- W3137520281 cites W2588614813 @default.
- W3137520281 cites W2604768034 @default.
- W3137520281 cites W2608926410 @default.
- W3137520281 cites W2609543937 @default.
- W3137520281 cites W2617605538 @default.
- W3137520281 cites W2618984243 @default.
- W3137520281 cites W2734434515 @default.
- W3137520281 cites W2848978533 @default.
- W3137520281 cites W2885745997 @default.
- W3137520281 cites W2892911593 @default.
- W3137520281 cites W2898650521 @default.
- W3137520281 cites W2901728784 @default.
- W3137520281 cites W2902328763 @default.
- W3137520281 cites W2902745272 @default.
- W3137520281 cites W2902955133 @default.
- W3137520281 cites W2920375683 @default.
- W3137520281 cites W2944605044 @default.
- W3137520281 cites W2945524279 @default.
- W3137520281 cites W2969949762 @default.
- W3137520281 cites W2972470504 @default.
- W3137520281 cites W2972802670 @default.
- W3137520281 cites W2974057056 @default.
- W3137520281 cites W2980989947 @default.
- W3137520281 cites W2982221027 @default.
- W3137520281 cites W2987850771 @default.
- W3137520281 cites W2996070127 @default.
- W3137520281 cites W2997944188 @default.
- W3137520281 cites W3001493537 @default.
- W3137520281 cites W3004830249 @default.
- W3137520281 cites W3011005820 @default.
- W3137520281 cites W3024375461 @default.
- W3137520281 cites W3028277312 @default.
- W3137520281 cites W3028800184 @default.
- W3137520281 cites W3039823791 @default.
- W3137520281 cites W3041635484 @default.
- W3137520281 cites W3046772142 @default.
- W3137520281 cites W3047613370 @default.
- W3137520281 cites W3061843793 @default.
- W3137520281 cites W3082366829 @default.
- W3137520281 cites W3082719615 @default.
- W3137520281 cites W3098138308 @default.
- W3137520281 cites W3125503134 @default.
- W3137520281 cites W3128685531 @default.
- W3137520281 cites W3129818723 @default.
- W3137520281 cites W3142398284 @default.
- W3137520281 cites W3183857127 @default.
- W3137520281 cites W4251222458 @default.
- W3137520281 cites W56038340 @default.
- W3137520281 doi "https://doi.org/10.1016/j.jlr.2021.100060" @default.
- W3137520281 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8065289" @default.
- W3137520281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33716107" @default.
- W3137520281 hasPublicationYear "2021" @default.
- W3137520281 type Work @default.
- W3137520281 sameAs 3137520281 @default.
- W3137520281 citedByCount "13" @default.
- W3137520281 countsByYear W31375202812021 @default.
- W3137520281 countsByYear W31375202812022 @default.
- W3137520281 countsByYear W31375202812023 @default.
- W3137520281 crossrefType "journal-article" @default.
- W3137520281 hasAuthorship W3137520281A5060465607 @default.
- W3137520281 hasBestOaLocation W31375202811 @default.
- W3137520281 hasConcept C126322002 @default.
- W3137520281 hasConcept C134018914 @default.
- W3137520281 hasConcept C2778163477 @default.
- W3137520281 hasConcept C2778657065 @default.
- W3137520281 hasConcept C2779120738 @default.
- W3137520281 hasConcept C2780072125 @default.
- W3137520281 hasConcept C2780948078 @default.
- W3137520281 hasConcept C43554185 @default.
- W3137520281 hasConcept C71924100 @default.