Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137527105> ?p ?o ?g. }
- W3137527105 endingPage "1606" @default.
- W3137527105 startingPage "1606" @default.
- W3137527105 abstract "Biocompatible tryptophan-derived copper (1) and zinc (2) complexes with norharmane (β-carboline) were designed, synthesized, characterized, and evaluated for the potential anticancer activity in vitro and in vivo. The in vitro cytotoxicity of both complexes 1 and 2 were assessed against two cancerous cells: (human breast cancer) MCF7 and (liver hepatocellular cancer) HepG2 cells with a non-tumorigenic: (human embryonic kidney) HEK293 cells. The results exhibited a potentially decent selectivity of 1 against MCF7 cells with an IC50 value of 7.8 ± 0.4 μM compared to 2 (less active, IC50 ~ 20 μM). Furthermore, we analyzed the level of glutathione, lipid peroxidation, and visualized ROS generation to get an insight into the mechanistic pathway and witnessed oxidative stress. These in vitro results were ascertained by in vivo experiments, which also supported the free radical-mediated oxidative stress. The comet assay confirmed the oxidative stress that leads to DNA damage. The histopathology of the liver also ascertained the low toxicity of 1." @default.
- W3137527105 created "2021-03-29" @default.
- W3137527105 creator A5041542534 @default.
- W3137527105 creator A5046899584 @default.
- W3137527105 creator A5055281495 @default.
- W3137527105 creator A5057825679 @default.
- W3137527105 creator A5067180206 @default.
- W3137527105 creator A5071385709 @default.
- W3137527105 creator A5071969181 @default.
- W3137527105 creator A5079079760 @default.
- W3137527105 creator A5090737758 @default.
- W3137527105 date "2021-03-14" @default.
- W3137527105 modified "2023-09-27" @default.
- W3137527105 title "Bioactive Tryptophan-Based Copper Complex with Auxiliary β-Carboline Spectacle Potential on Human Breast Cancer Cells: In Vitro and In Vivo Studies" @default.
- W3137527105 cites W1538399032 @default.
- W3137527105 cites W1590457525 @default.
- W3137527105 cites W1852168664 @default.
- W3137527105 cites W1876035649 @default.
- W3137527105 cites W1938025078 @default.
- W3137527105 cites W1965058852 @default.
- W3137527105 cites W1967853821 @default.
- W3137527105 cites W1969101934 @default.
- W3137527105 cites W1975165348 @default.
- W3137527105 cites W1975797915 @default.
- W3137527105 cites W1976372642 @default.
- W3137527105 cites W1978612964 @default.
- W3137527105 cites W1980411311 @default.
- W3137527105 cites W1982349773 @default.
- W3137527105 cites W1984883623 @default.
- W3137527105 cites W1986701803 @default.
- W3137527105 cites W1987604182 @default.
- W3137527105 cites W1991078204 @default.
- W3137527105 cites W1992954113 @default.
- W3137527105 cites W2005877813 @default.
- W3137527105 cites W2008445367 @default.
- W3137527105 cites W2008952105 @default.
- W3137527105 cites W2010311619 @default.
- W3137527105 cites W2021231925 @default.
- W3137527105 cites W2023271753 @default.
- W3137527105 cites W2025259793 @default.
- W3137527105 cites W2029494903 @default.
- W3137527105 cites W2039559098 @default.
- W3137527105 cites W2042190789 @default.
- W3137527105 cites W2044490585 @default.
- W3137527105 cites W2049191626 @default.
- W3137527105 cites W2050737616 @default.
- W3137527105 cites W2051456776 @default.
- W3137527105 cites W2054594589 @default.
- W3137527105 cites W2058848030 @default.
- W3137527105 cites W2059518107 @default.
- W3137527105 cites W2068617439 @default.
- W3137527105 cites W2069384792 @default.
- W3137527105 cites W2073092594 @default.
- W3137527105 cites W2073131323 @default.
- W3137527105 cites W2073607912 @default.
- W3137527105 cites W2076940601 @default.
- W3137527105 cites W2077846279 @default.
- W3137527105 cites W2088581219 @default.
- W3137527105 cites W2089477376 @default.
- W3137527105 cites W2090070900 @default.
- W3137527105 cites W2092629964 @default.
- W3137527105 cites W2104033196 @default.
- W3137527105 cites W2114467922 @default.
- W3137527105 cites W2115003365 @default.
- W3137527105 cites W2130861836 @default.
- W3137527105 cites W2137924654 @default.
- W3137527105 cites W2142047207 @default.
- W3137527105 cites W2148284063 @default.
- W3137527105 cites W2161817637 @default.
- W3137527105 cites W2168535650 @default.
- W3137527105 cites W2173388827 @default.
- W3137527105 cites W2173698400 @default.
- W3137527105 cites W2219206020 @default.
- W3137527105 cites W2236515064 @default.
- W3137527105 cites W2276802807 @default.
- W3137527105 cites W2282989227 @default.
- W3137527105 cites W2313035794 @default.
- W3137527105 cites W2334295323 @default.
- W3137527105 cites W2408738855 @default.
- W3137527105 cites W2413696366 @default.
- W3137527105 cites W2413990098 @default.
- W3137527105 cites W2462158203 @default.
- W3137527105 cites W2612072986 @default.
- W3137527105 cites W2792286754 @default.
- W3137527105 cites W2885805685 @default.
- W3137527105 cites W2900448600 @default.
- W3137527105 cites W2912474054 @default.
- W3137527105 cites W2920256030 @default.
- W3137527105 cites W2966459653 @default.
- W3137527105 cites W3020857587 @default.
- W3137527105 cites W3042334597 @default.
- W3137527105 cites W3109636966 @default.
- W3137527105 cites W3111889422 @default.
- W3137527105 doi "https://doi.org/10.3390/molecules26061606" @default.
- W3137527105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8001361" @default.
- W3137527105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33799355" @default.
- W3137527105 hasPublicationYear "2021" @default.
- W3137527105 type Work @default.