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- W3137555263 endingPage "146464" @default.
- W3137555263 startingPage "146464" @default.
- W3137555263 abstract "Ambient air pollution contributes to 7 million premature deaths annually. Concurrently, the ongoing coronavirus disease 2019 (COVID-19) pandemic, complicated with S-protein mutations and other variants, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in over 2.5 million deaths globally. Chronic air pollution-mediated cardiopulmonary diseases have been associated with an increased incidence of hospitalization and mechanical ventilation following COVID-19 transmission. While the underlying mechanisms responsible for this association remain elusive, air pollutant-induced vascular oxidative stress and inflammatory responses have been implicated in amplifying COVID-19-mediated cytokine release and vascular thrombosis. In addition, prolonged exposure to certain types of particulate matter (PM2.5, d < 2.5 μm) has also been correlated with increased lung epithelial and vascular endothelial expression of the angiotensin-converting enzyme-2 (ACE2) receptors to which the SARS-CoV-2 spike glycoproteins (S) bind for fusion and internalization into host cells. Emerging literature has linked high rates of SARS-CoV-2 infection to regions with elevated levels of PM2.5, suggesting that COVID-19 lockdowns have been implicated in regional reductions in air pollutant-mediated cardiopulmonary effects. Taken together, an increased incidence of SARS-CoV-2-mediated cardiopulmonary diseases seems to overlap with highly polluted regions. To this end, we will review the redox-active components of air pollutants, the pathophysiology of SARS-CoV-2 transmission, and the key oxidative mechanisms and ACE2 overexpression underlying air pollution-exacerbated SARS-CoV-2 transmission." @default.
- W3137555263 created "2021-03-29" @default.
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- W3137555263 creator A5081873818 @default.
- W3137555263 date "2021-07-01" @default.
- W3137555263 modified "2023-10-16" @default.
- W3137555263 title "Association of COVID-19 transmission with high levels of ambient pollutants: Initiation and impact of the inflammatory response on cardiopulmonary disease" @default.
- W3137555263 cites W127352138 @default.
- W3137555263 cites W1526783415 @default.
- W3137555263 cites W1561748823 @default.
- W3137555263 cites W1797360749 @default.
- W3137555263 cites W1875917265 @default.
- W3137555263 cites W1934101734 @default.
- W3137555263 cites W1980422782 @default.
- W3137555263 cites W1995666039 @default.
- W3137555263 cites W1996532036 @default.
- W3137555263 cites W2003702772 @default.
- W3137555263 cites W2005819285 @default.
- W3137555263 cites W2009011345 @default.
- W3137555263 cites W2009689721 @default.
- W3137555263 cites W2012394874 @default.
- W3137555263 cites W2021290497 @default.
- W3137555263 cites W2022241658 @default.
- W3137555263 cites W2025939977 @default.
- W3137555263 cites W2027535484 @default.
- W3137555263 cites W2042389797 @default.
- W3137555263 cites W2051105080 @default.
- W3137555263 cites W2051155395 @default.
- W3137555263 cites W2054606393 @default.
- W3137555263 cites W2057581290 @default.
- W3137555263 cites W2064272233 @default.
- W3137555263 cites W2071850057 @default.
- W3137555263 cites W2073473383 @default.
- W3137555263 cites W2079542236 @default.
- W3137555263 cites W2083332491 @default.
- W3137555263 cites W2098415495 @default.
- W3137555263 cites W2102158401 @default.
- W3137555263 cites W2107115075 @default.
- W3137555263 cites W2110993019 @default.
- W3137555263 cites W2114332042 @default.
- W3137555263 cites W2116237065 @default.
- W3137555263 cites W2119042712 @default.
- W3137555263 cites W2121681651 @default.
- W3137555263 cites W2127272185 @default.
- W3137555263 cites W2132381469 @default.
- W3137555263 cites W2136766739 @default.
- W3137555263 cites W2138998720 @default.
- W3137555263 cites W2148316980 @default.
- W3137555263 cites W2148562253 @default.
- W3137555263 cites W2161477365 @default.
- W3137555263 cites W2163627712 @default.
- W3137555263 cites W2166604768 @default.
- W3137555263 cites W2169156080 @default.
- W3137555263 cites W2318698569 @default.
- W3137555263 cites W2347159189 @default.
- W3137555263 cites W2396428021 @default.
- W3137555263 cites W2399239317 @default.
- W3137555263 cites W2424144111 @default.
- W3137555263 cites W2534879302 @default.
- W3137555263 cites W2547156924 @default.
- W3137555263 cites W2564523466 @default.
- W3137555263 cites W2586587123 @default.
- W3137555263 cites W2588619268 @default.
- W3137555263 cites W2765237212 @default.
- W3137555263 cites W28345586 @default.
- W3137555263 cites W2885560675 @default.
- W3137555263 cites W2886559274 @default.
- W3137555263 cites W2898149752 @default.
- W3137555263 cites W2912500993 @default.
- W3137555263 cites W2963269847 @default.
- W3137555263 cites W2999409984 @default.
- W3137555263 cites W3003217347 @default.
- W3137555263 cites W3003943436 @default.
- W3137555263 cites W3004280078 @default.
- W3137555263 cites W3007246056 @default.
- W3137555263 cites W3009335299 @default.
- W3137555263 cites W3009885589 @default.
- W3137555263 cites W3009912996 @default.
- W3137555263 cites W3010848803 @default.
- W3137555263 cites W3010940342 @default.
- W3137555263 cites W3011127849 @default.
- W3137555263 cites W3011242477 @default.
- W3137555263 cites W3012099172 @default.
- W3137555263 cites W3012454642 @default.
- W3137555263 cites W3012573814 @default.
- W3137555263 cites W3013449264 @default.
- W3137555263 cites W3013619034 @default.
- W3137555263 cites W3013879969 @default.
- W3137555263 cites W3013893137 @default.
- W3137555263 cites W3015019427 @default.
- W3137555263 cites W3015324543 @default.
- W3137555263 cites W3015370197 @default.
- W3137555263 cites W3015438945 @default.
- W3137555263 cites W3015611095 @default.