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- W3137573777 endingPage "1525" @default.
- W3137573777 startingPage "1525" @default.
- W3137573777 abstract "Dendritic cells (DCs) prime anti-tumor T cell responses in tumor-draining lymph nodes and can restimulate T effector responses in the tumor site. Thus, in addition to unleashing T cell effector activity, current immunotherapies should be directed to boost DC function. Herein, we review the potential function of Flt3L as a tool for cancer immunotherapy. Flt3L is a growth factor that acts in Flt3-expressing multipotent progenitors and common lymphoid progenitors. Despite the broad expression of Flt3 in the hematopoietic progenitors, the main effect of the Flt3/Flt3L axis, revealed by the characterization of mice deficient in these genes, is the generation of conventional DCs (cDCs) and plasmacytoid DCs (pDCs). However, Flt3 signaling through PI3K and mTOR may also affect the function of mature DCs. We recapitulate the use of Flt3L in preclinical studies either as a single agent or in combination with other cancer therapies. We also analyze the use of Flt3L in clinical trials. The strong correlation between type 1 cDC (cDC1) infiltration of human cancers with overall survival in many cancer types suggests the potential use of Flt3L to boost expansion of this DC subset. However, this may need the combination of Flt3L with other immunomodulatory agents to boost cancer immunotherapy." @default.
- W3137573777 created "2021-03-29" @default.
- W3137573777 creator A5047641235 @default.
- W3137573777 creator A5071447191 @default.
- W3137573777 date "2021-03-26" @default.
- W3137573777 modified "2023-10-17" @default.
- W3137573777 title "The Flt3L/Flt3 Axis in Dendritic Cell Biology and Cancer Immunotherapy" @default.
- W3137573777 cites W1410010118 @default.
- W3137573777 cites W1497894656 @default.
- W3137573777 cites W1498931318 @default.
- W3137573777 cites W154795380 @default.
- W3137573777 cites W1640609747 @default.
- W3137573777 cites W1661544713 @default.
- W3137573777 cites W1858218633 @default.
- W3137573777 cites W1871654462 @default.
- W3137573777 cites W1960585934 @default.
- W3137573777 cites W1969366020 @default.
- W3137573777 cites W1971028883 @default.
- W3137573777 cites W1975766472 @default.
- W3137573777 cites W1976199086 @default.
- W3137573777 cites W1981253936 @default.
- W3137573777 cites W1990417936 @default.
- W3137573777 cites W1991155492 @default.
- W3137573777 cites W1996606746 @default.
- W3137573777 cites W1997553523 @default.
- W3137573777 cites W2004207939 @default.
- W3137573777 cites W2005582018 @default.
- W3137573777 cites W2012148175 @default.
- W3137573777 cites W2022262230 @default.
- W3137573777 cites W2036564362 @default.
- W3137573777 cites W2046505430 @default.
- W3137573777 cites W2049360002 @default.
- W3137573777 cites W2065086280 @default.
- W3137573777 cites W2068557660 @default.
- W3137573777 cites W2069891658 @default.
- W3137573777 cites W2071432029 @default.
- W3137573777 cites W2077701601 @default.
- W3137573777 cites W2085166569 @default.
- W3137573777 cites W2085397716 @default.
- W3137573777 cites W2089401084 @default.
- W3137573777 cites W2090549486 @default.
- W3137573777 cites W2090685407 @default.
- W3137573777 cites W2101642059 @default.
- W3137573777 cites W2106856686 @default.
- W3137573777 cites W2106883237 @default.
- W3137573777 cites W2107265716 @default.
- W3137573777 cites W2110213545 @default.
- W3137573777 cites W2118449798 @default.
- W3137573777 cites W2123158501 @default.
- W3137573777 cites W2126705611 @default.
- W3137573777 cites W2129503578 @default.
- W3137573777 cites W2142084466 @default.
- W3137573777 cites W2142530756 @default.
- W3137573777 cites W2144144301 @default.
- W3137573777 cites W2149639441 @default.
- W3137573777 cites W2151222524 @default.
- W3137573777 cites W2151551667 @default.
- W3137573777 cites W2155792963 @default.
- W3137573777 cites W2156498767 @default.
- W3137573777 cites W2156831625 @default.
- W3137573777 cites W2157737696 @default.
- W3137573777 cites W2160950237 @default.
- W3137573777 cites W2161354474 @default.
- W3137573777 cites W2168028214 @default.
- W3137573777 cites W2177948763 @default.
- W3137573777 cites W2180091996 @default.
- W3137573777 cites W2180137130 @default.
- W3137573777 cites W2222808047 @default.
- W3137573777 cites W2311869080 @default.
- W3137573777 cites W2318118720 @default.
- W3137573777 cites W232742645 @default.
- W3137573777 cites W2341604280 @default.
- W3137573777 cites W2416613119 @default.
- W3137573777 cites W2511769828 @default.
- W3137573777 cites W256420660 @default.
- W3137573777 cites W2605810679 @default.
- W3137573777 cites W2612805962 @default.
- W3137573777 cites W2735193073 @default.
- W3137573777 cites W2763770180 @default.
- W3137573777 cites W2781500522 @default.
- W3137573777 cites W2789167832 @default.
- W3137573777 cites W2789293028 @default.
- W3137573777 cites W2794194356 @default.
- W3137573777 cites W2803822216 @default.
- W3137573777 cites W2808909747 @default.
- W3137573777 cites W2885298105 @default.
- W3137573777 cites W2893742037 @default.
- W3137573777 cites W2902555145 @default.
- W3137573777 cites W2904099327 @default.
- W3137573777 cites W2906764918 @default.
- W3137573777 cites W2932352133 @default.
- W3137573777 cites W2938889495 @default.
- W3137573777 cites W2946906087 @default.
- W3137573777 cites W3024276903 @default.
- W3137573777 cites W3048641542 @default.
- W3137573777 cites W3100153578 @default.
- W3137573777 cites W4238827986 @default.
- W3137573777 doi "https://doi.org/10.3390/cancers13071525" @default.