Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137590711> ?p ?o ?g. }
- W3137590711 endingPage "734" @default.
- W3137590711 startingPage "727" @default.
- W3137590711 abstract "Nestin, a class VI intermediate filament protein of the cytoskeleton, and CD34, a transmembrane phosphoglycoprotein, are markers of progenitor cells. This study aimed to evaluate their expression and clinical significance in colorectal cancer.A clinically annotated tissue microarray, including 599 patients with colorectal cancer, was analyzed by immunohistochemistry. Furthermore, nestin and CD34 correlations with HIF-1a and a panel of cytokines and chemokines were assessed using quantitative reverse transcription PCR and The Cancer Genome Atlas dataset.Expression of nestin and CD34 was observed only in the tumor stroma. Patients displaying high expression of nestin and CD34 demonstrated higher rates of T1 and T2 tumors (p = .020), lower vascular invasion (p < .001) and improved 5-year overall survival (65%; 95% CI = 55-73 vs 45%; 95% CI = 37-53) after adjusting for clinicopathological characteristics (HR: 0.67; 95% CI = 0.46-0.96). A moderate to strong correlation (r = 0.37-0.78, p < .03) of nestin and CD34 was demonstrated for the following markers; HIF-1α, CD4, CD8, FOXP3, IRF1, GATA3, CCL2, CCL3, CXCL12 and CCL21.Combined expression of nestin and CD34 expression is associated with better overall survival possibly by modulating a favorable immune response." @default.
- W3137590711 created "2021-03-29" @default.
- W3137590711 creator A5001016808 @default.
- W3137590711 creator A5017417034 @default.
- W3137590711 creator A5022845568 @default.
- W3137590711 creator A5023044832 @default.
- W3137590711 creator A5025479665 @default.
- W3137590711 creator A5031592069 @default.
- W3137590711 creator A5034103482 @default.
- W3137590711 creator A5035588541 @default.
- W3137590711 creator A5038497681 @default.
- W3137590711 creator A5040620123 @default.
- W3137590711 creator A5051087530 @default.
- W3137590711 creator A5053612880 @default.
- W3137590711 creator A5057556096 @default.
- W3137590711 creator A5057848295 @default.
- W3137590711 creator A5059673120 @default.
- W3137590711 creator A5061535451 @default.
- W3137590711 creator A5063888318 @default.
- W3137590711 creator A5066210971 @default.
- W3137590711 creator A5075220118 @default.
- W3137590711 creator A5077713749 @default.
- W3137590711 creator A5083575348 @default.
- W3137590711 creator A5084744895 @default.
- W3137590711 creator A5085235678 @default.
- W3137590711 date "2021-03-18" @default.
- W3137590711 modified "2023-10-16" @default.
- W3137590711 title "Nestin and CD34 expression in colorectal cancer predicts improved overall survival" @default.
- W3137590711 cites W1521262132 @default.
- W3137590711 cites W1940485834 @default.
- W3137590711 cites W1968628080 @default.
- W3137590711 cites W1972648258 @default.
- W3137590711 cites W1973607597 @default.
- W3137590711 cites W1974441379 @default.
- W3137590711 cites W1978851576 @default.
- W3137590711 cites W1987145582 @default.
- W3137590711 cites W2002018357 @default.
- W3137590711 cites W2010704100 @default.
- W3137590711 cites W2027228490 @default.
- W3137590711 cites W2038219436 @default.
- W3137590711 cites W2041597588 @default.
- W3137590711 cites W2042626190 @default.
- W3137590711 cites W2049504854 @default.
- W3137590711 cites W2053967595 @default.
- W3137590711 cites W2062564272 @default.
- W3137590711 cites W2062874382 @default.
- W3137590711 cites W2066077534 @default.
- W3137590711 cites W2066379425 @default.
- W3137590711 cites W2071362026 @default.
- W3137590711 cites W2080780289 @default.
- W3137590711 cites W2084379028 @default.
- W3137590711 cites W2085212074 @default.
- W3137590711 cites W2087025867 @default.
- W3137590711 cites W2087810003 @default.
- W3137590711 cites W2089716357 @default.
- W3137590711 cites W2100820895 @default.
- W3137590711 cites W2102010795 @default.
- W3137590711 cites W2109531556 @default.
- W3137590711 cites W2117412164 @default.
- W3137590711 cites W2118001704 @default.
- W3137590711 cites W2126882378 @default.
- W3137590711 cites W2127004905 @default.
- W3137590711 cites W2138604360 @default.
- W3137590711 cites W2141269240 @default.
- W3137590711 cites W2147711201 @default.
- W3137590711 cites W2150633526 @default.
- W3137590711 cites W2151011478 @default.
- W3137590711 cites W2158092720 @default.
- W3137590711 cites W2158614492 @default.
- W3137590711 cites W2256234263 @default.
- W3137590711 cites W2262414037 @default.
- W3137590711 cites W2302003756 @default.
- W3137590711 cites W2326489905 @default.
- W3137590711 cites W2463268404 @default.
- W3137590711 cites W2466792968 @default.
- W3137590711 cites W2514576317 @default.
- W3137590711 cites W2591158083 @default.
- W3137590711 cites W2599866467 @default.
- W3137590711 cites W2889646458 @default.
- W3137590711 cites W3023050184 @default.
- W3137590711 cites W3048021583 @default.
- W3137590711 cites W4211199921 @default.
- W3137590711 doi "https://doi.org/10.1080/0284186x.2021.1891280" @default.
- W3137590711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33734917" @default.
- W3137590711 hasPublicationYear "2021" @default.
- W3137590711 type Work @default.
- W3137590711 sameAs 3137590711 @default.
- W3137590711 citedByCount "6" @default.
- W3137590711 countsByYear W31375907112021 @default.
- W3137590711 countsByYear W31375907112022 @default.
- W3137590711 countsByYear W31375907112023 @default.
- W3137590711 crossrefType "journal-article" @default.
- W3137590711 hasAuthorship W3137590711A5001016808 @default.
- W3137590711 hasAuthorship W3137590711A5017417034 @default.
- W3137590711 hasAuthorship W3137590711A5022845568 @default.
- W3137590711 hasAuthorship W3137590711A5023044832 @default.
- W3137590711 hasAuthorship W3137590711A5025479665 @default.
- W3137590711 hasAuthorship W3137590711A5031592069 @default.