FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137602932> ?p ?o ?g. }

• W3137602932 abstract "Current treatments for cholangiocarcinoma (CCA) are largely unsuccessful due to late diagnosis at advanced stage, leading to high mortality rate. Consequently, improved therapeutic approaches are urgently needed. Chimeric antigen receptor (CAR) T cell therapy is a newly potential therapy that can recognize specific surface antigen without major histocompatibility complex (MHC) restriction. Mucin 1 (MUC1) is an attractive candidate antigen as it is highly expressed and associated with poor prognosis and survival in CCA. We, therefore, set forth to create the fourth-generation CAR (CAR4) construct containing anti-MUC1-single-chain variable fragment (scFv) and three co-stimulatory domains (CD28, CD137, and CD27) linked to CD3ζ and evaluate anti-MUC1-CAR4 T cells in CCA models. Compared to untransduced T cells, anti-MUC1-CAR4 T cells produced increased levels of TNF-α, IFN-γ and granzyme B when exposed to MUC1-expressing KKU-100 and KKU-213A CCA cells (all p < 0.05). Anti-MUC1-CAR4 T cells demonstrated specific killing activity against KKU-100 (45.88 ± 7.45%, p < 0.05) and KKU-213A cells (66.03 ± 3.14%, p < 0.001) at an effector to target ratio of 5:1, but demonstrated negligible cytolytic activity against immortal cholangiocytes. Furthermore, the anti-MUC1-CAR4 T cells could effectively disrupt KKU-213A spheroids. These activities of anti-MUC1-CAR4 T cells supports the development of this approach as an adoptive T cell therapeutic strategy for CCA." @default.
• W3137602932 created "2021-03-29" @default.
• W3137602932 creator A5003446927 @default.
• W3137602932 creator A5008629890 @default.
• W3137602932 creator A5009328108 @default.
• W3137602932 creator A5014063904 @default.
• W3137602932 creator A5017605521 @default.
• W3137602932 creator A5021487213 @default.
• W3137602932 creator A5080049867 @default.
• W3137602932 creator A5090303993 @default.
• W3137602932 creator A5090528700 @default.
• W3137602932 date "2021-03-18" @default.
• W3137602932 modified "2023-10-05" @default.
• W3137602932 title "Anti-mucin 1 chimeric antigen receptor T cells for adoptive T cell therapy of cholangiocarcinoma" @default.
• W3137602932 cites W1502988744 @default.
• W3137602932 cites W1538386311 @default.
• W3137602932 cites W1619537825 @default.
• W3137602932 cites W1623064933 @default.
• W3137602932 cites W1767113662 @default.
• W3137602932 cites W1978739865 @default.
• W3137602932 cites W1984287161 @default.
• W3137602932 cites W2003494920 @default.
• W3137602932 cites W2016406358 @default.
• W3137602932 cites W2021472146 @default.
• W3137602932 cites W2022130522 @default.
• W3137602932 cites W2035104435 @default.
• W3137602932 cites W2039614598 @default.
• W3137602932 cites W2076991609 @default.
• W3137602932 cites W2090352184 @default.
• W3137602932 cites W2094501197 @default.
• W3137602932 cites W2099540110 @default.
• W3137602932 cites W2111348064 @default.
• W3137602932 cites W2112160778 @default.
• W3137602932 cites W2112347626 @default.
• W3137602932 cites W2125489343 @default.
• W3137602932 cites W2134121541 @default.
• W3137602932 cites W2144305967 @default.
• W3137602932 cites W2161098075 @default.
• W3137602932 cites W2161958391 @default.
• W3137602932 cites W2223273945 @default.
• W3137602932 cites W2232198960 @default.
• W3137602932 cites W2395845086 @default.
• W3137602932 cites W2460088816 @default.
• W3137602932 cites W2465142962 @default.
• W3137602932 cites W2465973558 @default.
• W3137602932 cites W2570463535 @default.
• W3137602932 cites W2750694869 @default.
• W3137602932 cites W2763230802 @default.
• W3137602932 cites W2779236169 @default.
• W3137602932 cites W2787301955 @default.
• W3137602932 cites W2793866022 @default.
• W3137602932 cites W2796341007 @default.
• W3137602932 cites W2806769509 @default.
• W3137602932 cites W2884091495 @default.
• W3137602932 cites W2898964988 @default.
• W3137602932 cites W2904963606 @default.
• W3137602932 cites W2922471907 @default.
• W3137602932 cites W2942230814 @default.
• W3137602932 cites W2945932464 @default.
• W3137602932 cites W2969348242 @default.
• W3137602932 cites W2976192812 @default.
• W3137602932 cites W2992050889 @default.
• W3137602932 cites W3038790873 @default.
• W3137602932 cites W3109369918 @default.
• W3137602932 cites W3120530230 @default.
• W3137602932 cites W4210975321 @default.
• W3137602932 doi "https://doi.org/10.1038/s41598-021-85747-9" @default.
• W3137602932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7973425" @default.
• W3137602932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33737613" @default.
• W3137602932 hasPublicationYear "2021" @default.
• W3137602932 type Work @default.
• W3137602932 sameAs 3137602932 @default.
• W3137602932 citedByCount "28" @default.
• W3137602932 countsByYear W31376029322021 @default.
• W3137602932 countsByYear W31376029322022 @default.
• W3137602932 countsByYear W31376029322023 @default.
• W3137602932 crossrefType "journal-article" @default.
• W3137602932 hasAuthorship W3137602932A5003446927 @default.
• W3137602932 hasAuthorship W3137602932A5008629890 @default.
• W3137602932 hasAuthorship W3137602932A5009328108 @default.
• W3137602932 hasAuthorship W3137602932A5014063904 @default.
• W3137602932 hasAuthorship W3137602932A5017605521 @default.
• W3137602932 hasAuthorship W3137602932A5021487213 @default.
• W3137602932 hasAuthorship W3137602932A5080049867 @default.
• W3137602932 hasAuthorship W3137602932A5090303993 @default.
• W3137602932 hasAuthorship W3137602932A5090528700 @default.
• W3137602932 hasBestOaLocation W31376029321 @default.
• W3137602932 hasConcept C147483822 @default.
• W3137602932 hasConcept C153911025 @default.
• W3137602932 hasConcept C167672396 @default.
• W3137602932 hasConcept C185592680 @default.
• W3137602932 hasConcept C19317047 @default.
• W3137602932 hasConcept C203014093 @default.
• W3137602932 hasConcept C2776090121 @default.
• W3137602932 hasConcept C2777421810 @default.
• W3137602932 hasConcept C2780380082 @default.
• W3137602932 hasConcept C3875195 @default.
• W3137602932 hasConcept C502942594 @default.
• W3137602932 hasConcept C86803240 @default.
• W3137602932 hasConcept C8891405 @default.

• next