FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137661988> ?p ?o ?g. }

• W3137661988 endingPage "2326" @default.
• W3137661988 startingPage "2314" @default.
• W3137661988 abstract "The apelinergic system (AS) is a novel pleiotropic system with an essential role in renal and cardiovascular physiology and disease, including water homeostasis and blood pressure regulation. It consists of two highly conserved peptide ligands, apelin and apela, and a G-protein-coupled apelin receptor. The two ligands have many isoforms and a short half-life and exert both similar and divergent effects. Vasopressin, apelin and their receptors colocalize in hypothalamic regions essential for body fluid homeostasis and interact at the central and renal levels to regulate water homeostasis and diuresis in inverse directions. In addition, the AS and renin-angiotensin system interact both systemically and in the kidney, with implications for the cardiovascular system. A role for the AS in diverse pathological states, including disorders of sodium and water balance, hypertension, heart failure, pre-eclampsia, acute kidney injury, sepsis and diabetic nephropathy, has recently been reported. Furthermore, several metabolically stable apelin analogues have been developed, with potential applications in diverse diseases. We review here what is currently known about the physiological functions of the AS, focusing on renal, cardiovascular and metabolic homeostasis, and the role of the AS in associated diseases. We also describe several hurdles and research opportunities worthy of the attention of the nephrology community." @default.
• W3137661988 created "2021-03-29" @default.
• W3137661988 creator A5017782999 @default.
• W3137661988 creator A5064202053 @default.
• W3137661988 creator A5066508291 @default.
• W3137661988 creator A5070519498 @default.
• W3137661988 creator A5080260698 @default.
• W3137661988 creator A5089036361 @default.
• W3137661988 date "2021-03-21" @default.
• W3137661988 modified "2023-10-18" @default.
• W3137661988 title "The emerging role of the apelinergic system in kidney physiology and disease" @default.
• W3137661988 cites W1511152517 @default.
• W3137661988 cites W1538705743 @default.
• W3137661988 cites W1555889043 @default.
• W3137661988 cites W1592232168 @default.
• W3137661988 cites W1608258137 @default.
• W3137661988 cites W1955514206 @default.
• W3137661988 cites W1967614023 @default.
• W3137661988 cites W1970453310 @default.
• W3137661988 cites W1974740818 @default.
• W3137661988 cites W1979074215 @default.
• W3137661988 cites W1981058771 @default.
• W3137661988 cites W1981721282 @default.
• W3137661988 cites W1983211931 @default.
• W3137661988 cites W1986525663 @default.
• W3137661988 cites W1987893946 @default.
• W3137661988 cites W1989706089 @default.
• W3137661988 cites W1991523226 @default.
• W3137661988 cites W1991635774 @default.
• W3137661988 cites W1997028164 @default.
• W3137661988 cites W2000993281 @default.
• W3137661988 cites W2001994083 @default.
• W3137661988 cites W2006812675 @default.
• W3137661988 cites W2008589619 @default.
• W3137661988 cites W2010884275 @default.
• W3137661988 cites W2012846412 @default.
• W3137661988 cites W2013824152 @default.
• W3137661988 cites W2015860087 @default.
• W3137661988 cites W2018991117 @default.
• W3137661988 cites W2020905941 @default.
• W3137661988 cites W2030963352 @default.
• W3137661988 cites W2038462292 @default.
• W3137661988 cites W2042865662 @default.
• W3137661988 cites W2043354554 @default.
• W3137661988 cites W2043505422 @default.
• W3137661988 cites W2047093986 @default.
• W3137661988 cites W2054035015 @default.
• W3137661988 cites W2055083597 @default.
• W3137661988 cites W2058042202 @default.
• W3137661988 cites W2060660919 @default.
• W3137661988 cites W2069333438 @default.
• W3137661988 cites W2075268421 @default.
• W3137661988 cites W2075714512 @default.
• W3137661988 cites W2081184877 @default.
• W3137661988 cites W2082827405 @default.
• W3137661988 cites W2083350649 @default.
• W3137661988 cites W2087458930 @default.
• W3137661988 cites W2089713519 @default.
• W3137661988 cites W2094518156 @default.
• W3137661988 cites W2096979174 @default.
• W3137661988 cites W2098223295 @default.
• W3137661988 cites W2098905900 @default.
• W3137661988 cites W2106530664 @default.
• W3137661988 cites W2106632025 @default.
• W3137661988 cites W2109058223 @default.
• W3137661988 cites W2117196163 @default.
• W3137661988 cites W2119230474 @default.
• W3137661988 cites W2120593855 @default.
• W3137661988 cites W2120772590 @default.
• W3137661988 cites W2121610003 @default.
• W3137661988 cites W2122225224 @default.
• W3137661988 cites W2122822263 @default.
• W3137661988 cites W2127087522 @default.
• W3137661988 cites W2132257581 @default.
• W3137661988 cites W2132493114 @default.
• W3137661988 cites W2151884708 @default.
• W3137661988 cites W2152256079 @default.
• W3137661988 cites W2155885188 @default.
• W3137661988 cites W2158962006 @default.
• W3137661988 cites W2161724835 @default.
• W3137661988 cites W2163865644 @default.
• W3137661988 cites W2164256953 @default.
• W3137661988 cites W2165312739 @default.
• W3137661988 cites W2180268264 @default.
• W3137661988 cites W2292914592 @default.
• W3137661988 cites W2295316990 @default.
• W3137661988 cites W2296782701 @default.
• W3137661988 cites W2301551035 @default.
• W3137661988 cites W2401854918 @default.
• W3137661988 cites W2476813941 @default.
• W3137661988 cites W2478469703 @default.
• W3137661988 cites W2480035352 @default.
• W3137661988 cites W2512693135 @default.
• W3137661988 cites W2547465013 @default.
• W3137661988 cites W2548162453 @default.
• W3137661988 cites W2549370199 @default.
• W3137661988 cites W2550051477 @default.
• W3137661988 cites W2583089302 @default.

• next