FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137675424> ?p ?o ?g. }

• W3137675424 endingPage "9626" @default.
• W3137675424 startingPage "9613" @default.
• W3137675424 abstract "Renal cell carcinoma (RCC) is a form of cancer arising from the renal epithelium, with high mortality rates that have reached stable levels over the past decade. The tumor microenvironment is an essential regulator of tumor progression and survival, and extracellular vesicles (EVs) are an important facet of this microenvironment. Herein, we explored the impact of hypoxia-induced miR-155 expression in EVs on FOXO3 expression in RCC cells and their associated oncogenic activity. We found that RCC patients exhibited elevated miR-155 expression in EVs relative to healthy controls, suggesting that this miRNA may be important in the context of RCC progression. We then characterized EVs produced from RCC cell lines (Caki-1 and 786-O) under normoxic and hypoxic conditions, revealing that hypoxia-induced EVs contained higher levels of miR-155 and promoted cell proliferation. Then, we identified FOXO3 as a miR-155 target. Lastly, hypoxia-induced EVs were found to be able to significantly inhibit FOXO3 activation via facilitating miR-155 up-regulation. Together, these findings indicate that hypoxia can promote the upregulation of miR-155 in EVs and that this miRNA can act in RCC cells to suppress FOXO3 expression, thereby enhancing cellular tumor progression." @default.
• W3137675424 created "2021-03-29" @default.
• W3137675424 creator A5030526678 @default.
• W3137675424 creator A5046911470 @default.
• W3137675424 creator A5059545505 @default.
• W3137675424 creator A5085656519 @default.
• W3137675424 creator A5087592842 @default.
• W3137675424 date "2021-03-19" @default.
• W3137675424 modified "2023-10-16" @default.
• W3137675424 title "Hypoxia-induced microRNA-155 overexpression in extracellular vesicles promotes renal cell carcinoma progression by targeting FOXO3" @default.
• W3137675424 cites W1762620449 @default.
• W3137675424 cites W1965296962 @default.
• W3137675424 cites W1975151676 @default.
• W3137675424 cites W2015284016 @default.
• W3137675424 cites W2033278321 @default.
• W3137675424 cites W2042699075 @default.
• W3137675424 cites W2055313665 @default.
• W3137675424 cites W2107961632 @default.
• W3137675424 cites W2108057472 @default.
• W3137675424 cites W2121354606 @default.
• W3137675424 cites W2168083201 @default.
• W3137675424 cites W2292302642 @default.
• W3137675424 cites W2331760055 @default.
• W3137675424 cites W2339848282 @default.
• W3137675424 cites W2340796679 @default.
• W3137675424 cites W2538955856 @default.
• W3137675424 cites W2580990361 @default.
• W3137675424 cites W2600552753 @default.
• W3137675424 cites W2621810949 @default.
• W3137675424 cites W2889646458 @default.
• W3137675424 cites W2904628185 @default.
• W3137675424 cites W2942669148 @default.
• W3137675424 cites W2949609635 @default.
• W3137675424 cites W2972802464 @default.
• W3137675424 cites W2975302076 @default.
• W3137675424 cites W2979410128 @default.
• W3137675424 cites W2979694024 @default.
• W3137675424 cites W2979930460 @default.
• W3137675424 cites W2999851564 @default.
• W3137675424 doi "https://doi.org/10.18632/aging.202706" @default.
• W3137675424 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8064184" @default.
• W3137675424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33742606" @default.
• W3137675424 hasPublicationYear "2021" @default.
• W3137675424 type Work @default.
• W3137675424 sameAs 3137675424 @default.
• W3137675424 citedByCount "16" @default.
• W3137675424 countsByYear W31376754242021 @default.
• W3137675424 countsByYear W31376754242022 @default.
• W3137675424 countsByYear W31376754242023 @default.
• W3137675424 crossrefType "journal-article" @default.
• W3137675424 hasAuthorship W3137675424A5030526678 @default.
• W3137675424 hasAuthorship W3137675424A5046911470 @default.
• W3137675424 hasAuthorship W3137675424A5059545505 @default.
• W3137675424 hasAuthorship W3137675424A5085656519 @default.
• W3137675424 hasAuthorship W3137675424A5087592842 @default.
• W3137675424 hasBestOaLocation W31376754241 @default.
• W3137675424 hasConcept C104317684 @default.
• W3137675424 hasConcept C127561419 @default.
• W3137675424 hasConcept C145059251 @default.
• W3137675424 hasConcept C168003608 @default.
• W3137675424 hasConcept C178790620 @default.
• W3137675424 hasConcept C185592680 @default.
• W3137675424 hasConcept C20518536 @default.
• W3137675424 hasConcept C28406088 @default.
• W3137675424 hasConcept C2908689518 @default.
• W3137675424 hasConcept C2992929900 @default.
• W3137675424 hasConcept C502942594 @default.
• W3137675424 hasConcept C540031477 @default.
• W3137675424 hasConcept C55493867 @default.
• W3137675424 hasConcept C71924100 @default.
• W3137675424 hasConcept C7836513 @default.
• W3137675424 hasConcept C86803240 @default.
• W3137675424 hasConcept C95444343 @default.
• W3137675424 hasConceptScore W3137675424C104317684 @default.
• W3137675424 hasConceptScore W3137675424C127561419 @default.
• W3137675424 hasConceptScore W3137675424C145059251 @default.
• W3137675424 hasConceptScore W3137675424C168003608 @default.
• W3137675424 hasConceptScore W3137675424C178790620 @default.
• W3137675424 hasConceptScore W3137675424C185592680 @default.
• W3137675424 hasConceptScore W3137675424C20518536 @default.
• W3137675424 hasConceptScore W3137675424C28406088 @default.
• W3137675424 hasConceptScore W3137675424C2908689518 @default.
• W3137675424 hasConceptScore W3137675424C2992929900 @default.
• W3137675424 hasConceptScore W3137675424C502942594 @default.
• W3137675424 hasConceptScore W3137675424C540031477 @default.
• W3137675424 hasConceptScore W3137675424C55493867 @default.
• W3137675424 hasConceptScore W3137675424C71924100 @default.
• W3137675424 hasConceptScore W3137675424C7836513 @default.
• W3137675424 hasConceptScore W3137675424C86803240 @default.
• W3137675424 hasConceptScore W3137675424C95444343 @default.
• W3137675424 hasIssue "7" @default.
• W3137675424 hasLocation W31376754241 @default.
• W3137675424 hasLocation W31376754242 @default.
• W3137675424 hasOpenAccess W3137675424 @default.
• W3137675424 hasPrimaryLocation W31376754241 @default.
• W3137675424 hasRelatedWork W2059234380 @default.
• W3137675424 hasRelatedWork W2161617639 @default.
• W3137675424 hasRelatedWork W2464399839 @default.

• next