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- W3137680129 abstract "Postpartum depression (PPD) is a mood disorder that usually emerges during the first 4 postpartum weeks but can also develop later during the first postnatal year. The etiology and pathogenesis of PPD remain unclear. In addition to unfavorable socioeconomic conditions and physiological disturbance, molecular alterations have been explored as risk factors for PPD development. This review summarizes the existing data regarding the role of genetic and epigenetic modifications of specific genes in PPD etiology and pathogenesis. Specifically, genes encoding female reproductive hormones, stress, inflammation-related components, neuropeptides, and mood modulators are discussed. Attempts to characterize global expression changes, which may be an underlying mechanism for PPD, are also addressed. The existing molecular and genetic studies are very conflicting and contentious. Probably, PPD is a complex condition resulting from the integration of various environmental and homeostatic changes." @default.
- W3137680129 created "2021-03-29" @default.
- W3137680129 creator A5025754765 @default.
- W3137680129 date "2021-01-01" @default.
- W3137680129 modified "2023-10-06" @default.
- W3137680129 title "Gene expression in depression: Molecular aspects of postpartum depression" @default.
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- W3137680129 doi "https://doi.org/10.1016/b978-0-12-817935-2.00012-x" @default.
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