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• W3137686500 abstract "Last two decades, the studies on microRNAs (miRNAs) and the numbers of annotated miRNAs in plants and animals have surged. Herein, we reviewed the current progress and challenges of miRNA annotation in plants. Via the comparison of plant and animal miRNAs, we pinpointed out the difficulties on plant miRNA annotation and proposed potential solutions. In terms of recalling the history of methods and criteria in plant miRNA annotation, we detailed how the major progresses made and evolved. By collecting and categorizing bioinformatics tools for plant miRNA annotation, we surveyed their advantages and disadvantages, especially for ones with the principle of mimicking the miRNA biogenesis pathway by parsing deeply sequenced small RNA (sRNA) libraries. In addition, we summarized all available databases hosting plant miRNAs, and posted the potential optimization solutions such as how to increase the signal-to-noise ratio (SNR) in these databases. Finally, we discussed the challenges and perspectives of plant miRNA annotations, and indicated the possibilities offered by an all-in-one tool and platform according to the integration of artificial intelligence." @default.
• W3137686500 created "2021-03-29" @default.
• W3137686500 creator A5024351422 @default.
• W3137686500 creator A5044492362 @default.
• W3137686500 creator A5075889094 @default.
• W3137686500 creator A5082320333 @default.
• W3137686500 creator A5082889999 @default.
• W3137686500 date "2021-03-23" @default.
• W3137686500 modified "2023-10-16" @default.
• W3137686500 title "MicroRNA annotation in plants: current status and challenges" @default.
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