Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137705258> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W3137705258 endingPage "995" @default.
- W3137705258 startingPage "987" @default.
- W3137705258 abstract "Abstract Obstructive renal diseases affect renal function and kidney integrity. Nevertheless, little is known about its systemic or extra‐renal effects. The organic anion transporting polypeptide 1 (Oatp1) is a carrier expressed in liver and kidneys. In this study, the hepatic and renal expression of Oatp1 was evaluated in rats with obstructive nephropathy. Moreover, the urinary excretion of Oatp1 (Oatp1 u ) was evaluated as a potential biomarker for this pathology. Male Wistar rats with bilateral ureteral obstruction for 5 hours (BUO5), 24 hours (BUO24) or sham operated were used. After 24 hours of ureteral releasing, liver and kidney functional parameters, histopathology, Oatp1 tissular expression and Oatp1 u were evaluated. For Oatp1 u evaluation two groups were added; BUO1 and BUO2 (1 and 2 hours of ureteral obstruction, respectively). Both liver and kidney functional parameters and histopathological studies showed alterations in BUO5 and BUO24. In hepatic homogenates, Oatp1 significantly decreased in BUO groups and in total liver membranes no modifications were observed. In renal homogenates, Oatp1 significantly decreased in BUO groups, but in apical kidney membranes, its expression was increased. Oatp1 u was only detected in BUO groups, even in those (BUO1, BUO2) in which no alterations in the traditional parameters of renal function were observed. Modulations in liver and renal expression of Oatp1 could be an organism strategy to attenuate the effects of the disease and an attempt to maintain the complex organ cross‐talk between liver and kidneys. Oatp1 u could be a new, early and specific biomarker of obstructive nephropathy." @default.
- W3137705258 created "2021-03-29" @default.
- W3137705258 creator A5031936494 @default.
- W3137705258 creator A5043800546 @default.
- W3137705258 creator A5059387588 @default.
- W3137705258 creator A5068308353 @default.
- W3137705258 date "2021-04-08" @default.
- W3137705258 modified "2023-10-06" @default.
- W3137705258 title "Hepatic and renal expression of Oatp1 in obstructive uropathy. First detection of Oatp1 in urine, a potential biomarker" @default.
- W3137705258 cites W1520580779 @default.
- W3137705258 cites W1580841410 @default.
- W3137705258 cites W1886426933 @default.
- W3137705258 cites W1966052609 @default.
- W3137705258 cites W1970248362 @default.
- W3137705258 cites W1973508181 @default.
- W3137705258 cites W1997088049 @default.
- W3137705258 cites W2008785905 @default.
- W3137705258 cites W2019150978 @default.
- W3137705258 cites W2024370100 @default.
- W3137705258 cites W2028890879 @default.
- W3137705258 cites W2030910975 @default.
- W3137705258 cites W2045924581 @default.
- W3137705258 cites W2060883862 @default.
- W3137705258 cites W2062091289 @default.
- W3137705258 cites W2065309458 @default.
- W3137705258 cites W2067815451 @default.
- W3137705258 cites W2077501358 @default.
- W3137705258 cites W2081282242 @default.
- W3137705258 cites W2081680109 @default.
- W3137705258 cites W2142234431 @default.
- W3137705258 cites W2142875454 @default.
- W3137705258 cites W2160045092 @default.
- W3137705258 cites W2161469261 @default.
- W3137705258 cites W2170961031 @default.
- W3137705258 cites W2224333461 @default.
- W3137705258 cites W2570111907 @default.
- W3137705258 cites W2739549032 @default.
- W3137705258 cites W2793180998 @default.
- W3137705258 cites W2801001551 @default.
- W3137705258 cites W2883664573 @default.
- W3137705258 cites W2888544871 @default.
- W3137705258 cites W3033484604 @default.
- W3137705258 cites W4252245326 @default.
- W3137705258 doi "https://doi.org/10.1111/1440-1681.13499" @default.
- W3137705258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33738813" @default.
- W3137705258 hasPublicationYear "2021" @default.
- W3137705258 type Work @default.
- W3137705258 sameAs 3137705258 @default.
- W3137705258 citedByCount "2" @default.
- W3137705258 countsByYear W31377052582023 @default.
- W3137705258 crossrefType "journal-article" @default.
- W3137705258 hasAuthorship W3137705258A5031936494 @default.
- W3137705258 hasAuthorship W3137705258A5043800546 @default.
- W3137705258 hasAuthorship W3137705258A5059387588 @default.
- W3137705258 hasAuthorship W3137705258A5068308353 @default.
- W3137705258 hasConcept C126322002 @default.
- W3137705258 hasConcept C142724271 @default.
- W3137705258 hasConcept C159641895 @default.
- W3137705258 hasConcept C2780091579 @default.
- W3137705258 hasConcept C71924100 @default.
- W3137705258 hasConcept C86803240 @default.
- W3137705258 hasConceptScore W3137705258C126322002 @default.
- W3137705258 hasConceptScore W3137705258C142724271 @default.
- W3137705258 hasConceptScore W3137705258C159641895 @default.
- W3137705258 hasConceptScore W3137705258C2780091579 @default.
- W3137705258 hasConceptScore W3137705258C71924100 @default.
- W3137705258 hasConceptScore W3137705258C86803240 @default.
- W3137705258 hasIssue "7" @default.
- W3137705258 hasLocation W31377052581 @default.
- W3137705258 hasLocation W31377052582 @default.
- W3137705258 hasOpenAccess W3137705258 @default.
- W3137705258 hasPrimaryLocation W31377052581 @default.
- W3137705258 hasRelatedWork W2042033030 @default.
- W3137705258 hasRelatedWork W2044943066 @default.
- W3137705258 hasRelatedWork W2082456910 @default.
- W3137705258 hasRelatedWork W2127085070 @default.
- W3137705258 hasRelatedWork W2153939330 @default.
- W3137705258 hasRelatedWork W2226559187 @default.
- W3137705258 hasRelatedWork W2377006731 @default.
- W3137705258 hasRelatedWork W2400445066 @default.
- W3137705258 hasRelatedWork W2406923934 @default.
- W3137705258 hasRelatedWork W2411555844 @default.
- W3137705258 hasVolume "48" @default.
- W3137705258 isParatext "false" @default.
- W3137705258 isRetracted "false" @default.
- W3137705258 magId "3137705258" @default.
- W3137705258 workType "article" @default.