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• W3137729934 abstract "Background The immunologic pathways activated during snakebite envenoming (SBE) are poorly described, and their association with recovery is unclear. The immunologic response in SBE could inform a prognostic model to predict recovery. The purpose of this study was to develop pre- and post-antivenom prognostic models comprised of clinical features and immunologic cytokine data that are associated with recovery from SBE. Materials and Methods We performed a prospective cohort study in an academic medical center emergency department. We enrolled consecutive patients with Crotalinae SBE and obtained serum samples based on previously described criteria for the Surgical Critical Care Initiative (SC2i)(ClinicalTrials.gov Identifier: NCT02182180). We assessed a standard set of clinical variables and measured 35 unique cytokines using Luminex Cytokine 35-Plex Human Panel pre- and post-antivenom administration. The Patient-Specific Functional Scale (PSFS), a well-validated patient-reported outcome of functional recovery, was assessed at 0, 7, 14, 21 and 28 days and the area under the patient curve (PSFS AUPC) determined. We performed Bayesian Belief Network (BBN) modeling to represent relationships with a diagram composed of nodes and arcs. Each node represents a cytokine or clinical feature and each arc represents a joint-probability distribution (JPD). Results Twenty-eight SBE patients were enrolled. Preliminary results from 24 patients with clinical data, 9 patients with pre-antivenom and 11 patients with post-antivenom cytokine data are presented. The group was mostly female (82%) with a mean age of 38.1 (SD ± 9.8) years. In the pre-antivenom model, the variables most closely associated with the PSFS AUPC are predominantly clinical features. In the post-antivenom model, cytokines are more fully incorporated into the model. The variables most closely associated with the PSFS AUPC are age, antihistamines, white blood cell count (WBC), HGF, CCL5 and VEGF. The most influential variables are age, antihistamines and EGF. Both the pre- and post-antivenom models perform well with AUCs of 0.87 and 0.90 respectively. Discussion Pre- and post-antivenom networks of cytokines and clinical features were associated with functional recovery measured by the PSFS AUPC over 28 days. With additional data, we can identify prognostic models using immunologic and clinical variables to predict recovery from SBE." @default.
• W3137729934 created "2021-03-29" @default.
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• W3137729934 date "2021-03-15" @default.
• W3137729934 modified "2023-09-26" @default.
• W3137729934 title "Association of a Network of Immunologic Response and Clinical Features With the Functional Recovery From Crotalinae Snakebite Envenoming" @default.
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• W3137729934 cites W1970444280 @default.
• W3137729934 cites W1973204761 @default.
• W3137729934 cites W1984924733 @default.
• W3137729934 cites W1987339450 @default.
• W3137729934 cites W1988753912 @default.
• W3137729934 cites W1994827954 @default.
• W3137729934 cites W2002832003 @default.
• W3137729934 cites W2011758365 @default.
• W3137729934 cites W2012220123 @default.
• W3137729934 cites W2012598789 @default.
• W3137729934 cites W2014629917 @default.
• W3137729934 cites W2017262399 @default.
• W3137729934 cites W2023996535 @default.
• W3137729934 cites W2047965307 @default.
• W3137729934 cites W2060022205 @default.
• W3137729934 cites W2065229649 @default.
• W3137729934 cites W2065751459 @default.
• W3137729934 cites W2076909337 @default.
• W3137729934 cites W2081706997 @default.
• W3137729934 cites W2090587951 @default.
• W3137729934 cites W2101508172 @default.
• W3137729934 cites W2108738255 @default.
• W3137729934 cites W2117250036 @default.
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• W3137729934 cites W2314616925 @default.
• W3137729934 cites W2546983694 @default.
• W3137729934 cites W2554824773 @default.
• W3137729934 cites W2557935260 @default.
• W3137729934 cites W2619537995 @default.
• W3137729934 cites W2625141386 @default.
• W3137729934 cites W2766002859 @default.
• W3137729934 cites W2768357172 @default.
• W3137729934 cites W2796229507 @default.
• W3137729934 cites W2800759064 @default.
• W3137729934 cites W2803376439 @default.
• W3137729934 cites W2804839551 @default.
• W3137729934 cites W2891885419 @default.
• W3137729934 cites W2897339403 @default.
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• W3137729934 cites W2910997220 @default.
• W3137729934 cites W2914041355 @default.
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• W3137729934 cites W2958359323 @default.
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• W3137729934 doi "https://doi.org/10.3389/fimmu.2021.628113" @default.
• W3137729934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8006329" @default.
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• W3137729934 hasPublicationYear "2021" @default.
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