FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137759853> ?p ?o ?g. }

• W3137759853 abstract "New drugs that target the basic defect in cystic fibrosis (CF) patients may now be used in a large number of patients carrying responsive mutations. Nevertheless, further research is needed to extend the benefit of these treatments to patients with rare mutations that are still uncharacterized in vitro and that are not included in clinical trials. For this purpose, ex vivo models are necessary to preliminary assessing the effect of CFTR modulators in these cases.We report the clinical effectiveness of lumacaftor/ivacaftor therapy prescribed to a CF child with a rare genetic profile (p.Phe508del/p.Gly970Asp) after testing the drug on nasal epithelial cells. We observed a significant drop of the sweat chloride value, as of the lung clearance index. A longer follow-up period is needed to define the effects of therapy on pancreatic status, although an increase of the fecal elastase values was found.Drug response obtained on nasal epithelial cells correlates with changes in vivo therapeutic endpoints and can be a predictor of clinical efficacy of novel drugs especially in pediatric patients." @default.
• W3137759853 created "2021-03-29" @default.
• W3137759853 creator A5015011335 @default.
• W3137759853 creator A5047261074 @default.
• W3137759853 creator A5050025219 @default.
• W3137759853 creator A5059886022 @default.
• W3137759853 creator A5065989164 @default.
• W3137759853 creator A5072277956 @default.
• W3137759853 creator A5082533033 @default.
• W3137759853 date "2021-03-13" @default.
• W3137759853 modified "2023-10-02" @default.
• W3137759853 title "Ex vivo model predicted in vivo efficacy of CFTR modulator therapy in a child with rare genotype" @default.
• W3137759853 cites W1979519637 @default.
• W3137759853 cites W2015091838 @default.
• W3137759853 cites W2023305685 @default.
• W3137759853 cites W2031633609 @default.
• W3137759853 cites W2095687634 @default.
• W3137759853 cites W2103123445 @default.
• W3137759853 cites W2135584427 @default.
• W3137759853 cites W2152912650 @default.
• W3137759853 cites W2170769759 @default.
• W3137759853 cites W2522858042 @default.
• W3137759853 cites W2528039416 @default.
• W3137759853 cites W2530836088 @default.
• W3137759853 cites W2560320630 @default.
• W3137759853 cites W2764203291 @default.
• W3137759853 cites W2766370986 @default.
• W3137759853 cites W2781535207 @default.
• W3137759853 cites W2791688327 @default.
• W3137759853 cites W2888673303 @default.
• W3137759853 cites W2921217165 @default.
• W3137759853 cites W2938157684 @default.
• W3137759853 cites W2985405196 @default.
• W3137759853 cites W3032417039 @default.
• W3137759853 cites W3038637747 @default.
• W3137759853 cites W3039606807 @default.
• W3137759853 cites W3111925446 @default.
• W3137759853 cites W4206217612 @default.
• W3137759853 doi "https://doi.org/10.1002/mgg3.1656" @default.
• W3137759853 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8123755" @default.
• W3137759853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33713579" @default.
• W3137759853 hasPublicationYear "2021" @default.
• W3137759853 type Work @default.
• W3137759853 sameAs 3137759853 @default.
• W3137759853 citedByCount "18" @default.
• W3137759853 countsByYear W31377598532021 @default.
• W3137759853 countsByYear W31377598532022 @default.
• W3137759853 countsByYear W31377598532023 @default.
• W3137759853 crossrefType "journal-article" @default.
• W3137759853 hasAuthorship W3137759853A5015011335 @default.
• W3137759853 hasAuthorship W3137759853A5047261074 @default.
• W3137759853 hasAuthorship W3137759853A5050025219 @default.
• W3137759853 hasAuthorship W3137759853A5059886022 @default.
• W3137759853 hasAuthorship W3137759853A5065989164 @default.
• W3137759853 hasAuthorship W3137759853A5072277956 @default.
• W3137759853 hasAuthorship W3137759853A5082533033 @default.
• W3137759853 hasBestOaLocation W31377598532 @default.
• W3137759853 hasConcept C126322002 @default.
• W3137759853 hasConcept C149172746 @default.
• W3137759853 hasConcept C150903083 @default.
• W3137759853 hasConcept C207001950 @default.
• W3137759853 hasConcept C26291073 @default.
• W3137759853 hasConcept C2776502428 @default.
• W3137759853 hasConcept C2776938444 @default.
• W3137759853 hasConcept C2778428886 @default.
• W3137759853 hasConcept C2779879311 @default.
• W3137759853 hasConcept C2780035454 @default.
• W3137759853 hasConcept C535046627 @default.
• W3137759853 hasConcept C60644358 @default.
• W3137759853 hasConcept C71924100 @default.
• W3137759853 hasConcept C86803240 @default.
• W3137759853 hasConcept C98274493 @default.
• W3137759853 hasConceptScore W3137759853C126322002 @default.
• W3137759853 hasConceptScore W3137759853C149172746 @default.
• W3137759853 hasConceptScore W3137759853C150903083 @default.
• W3137759853 hasConceptScore W3137759853C207001950 @default.
• W3137759853 hasConceptScore W3137759853C26291073 @default.
• W3137759853 hasConceptScore W3137759853C2776502428 @default.
• W3137759853 hasConceptScore W3137759853C2776938444 @default.
• W3137759853 hasConceptScore W3137759853C2778428886 @default.
• W3137759853 hasConceptScore W3137759853C2779879311 @default.
• W3137759853 hasConceptScore W3137759853C2780035454 @default.
• W3137759853 hasConceptScore W3137759853C535046627 @default.
• W3137759853 hasConceptScore W3137759853C60644358 @default.
• W3137759853 hasConceptScore W3137759853C71924100 @default.
• W3137759853 hasConceptScore W3137759853C86803240 @default.
• W3137759853 hasConceptScore W3137759853C98274493 @default.
• W3137759853 hasFunder F4320321781 @default.
• W3137759853 hasIssue "4" @default.
• W3137759853 hasLocation W31377598531 @default.
• W3137759853 hasLocation W31377598532 @default.
• W3137759853 hasLocation W31377598533 @default.
• W3137759853 hasOpenAccess W3137759853 @default.
• W3137759853 hasPrimaryLocation W31377598531 @default.
• W3137759853 hasRelatedWork W1973829019 @default.
• W3137759853 hasRelatedWork W2023305685 @default.
• W3137759853 hasRelatedWork W2030208908 @default.
• W3137759853 hasRelatedWork W2055770793 @default.
• W3137759853 hasRelatedWork W2588687016 @default.
• W3137759853 hasRelatedWork W2994046072 @default.

• next