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- W3137797907 abstract "Background and objectives: Reactive oxygen species (ROS) overwhelm the antioxidant defense system, induce oxidative stress, and increase matrix metalloproteinase (MMP) expression, resulting in skin aging. Thus, preventing ultraviolet B (UVB)-induced skin damage can attenuate skin aging. Spirulina (a biomass of cyanobacteria, also called blue-green algae) is comprised of prokaryotes, whereas microalgae are eukaryotes and are rich in phycocyanin, a powerful antioxidant. Materials and Methods: Here, we investigated the photoprotective effects of spirulina-derived C-phycocyanin (C-PC) against UVB radiation using keratinocytes (HaCaT cells). Results: UVB radiation increased MMP-1 and MMP-9 expression but decreased involucrin, filaggrin, and loricrin expression. C-PC showed no toxicity at concentrations of 5–80 μg/mL in terms of HaCaT cell viability. UVB-irradiated HaCaT cells had a 50.8% survival rate, which increased to 80.3% with C-PC treatment. MMP expression increased with UVB treatment, whereas MMP-1 and MMP-9 concentrations decreased with C-PC treatment. UVB reduced involucrin, filaggrin, and loricrin expression in HaCaT cells, but 80 μg/mL C-PC increased their expression by >25%. In the UVB radiation group, dichlorofluorescin diacetate fluorescence intensity in HaCaT cells increased by 81.6% compared with that in the control group, whereas ROS production was reduced by 51.2% and 55.1% upon treatment with 40 and 80 μg/mL C-PC, respectively. Conclusions: C-PC might reduce or prevent skin aging by reducing UVB irradiation-induced skin wrinkles and free radicals." @default.
- W3137797907 created "2021-03-29" @default.
- W3137797907 creator A5003785570 @default.
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- W3137797907 date "2021-03-16" @default.
- W3137797907 modified "2023-09-24" @default.
- W3137797907 title "Protective Effect of Spirulina-Derived C-Phycocyanin against Ultraviolet B-Induced Damage in HaCaT Cells" @default.
- W3137797907 cites W1554998464 @default.
- W3137797907 cites W1798046137 @default.
- W3137797907 cites W1963793335 @default.
- W3137797907 cites W1978340010 @default.
- W3137797907 cites W1980013512 @default.
- W3137797907 cites W1983125814 @default.
- W3137797907 cites W1986226378 @default.
- W3137797907 cites W1996306954 @default.
- W3137797907 cites W1997523952 @default.
- W3137797907 cites W1998340266 @default.
- W3137797907 cites W1998348002 @default.
- W3137797907 cites W2001372725 @default.
- W3137797907 cites W2001523054 @default.
- W3137797907 cites W2001589466 @default.
- W3137797907 cites W2003927867 @default.
- W3137797907 cites W2004498595 @default.
- W3137797907 cites W2014240203 @default.
- W3137797907 cites W2014729003 @default.
- W3137797907 cites W2016867252 @default.
- W3137797907 cites W2018081553 @default.
- W3137797907 cites W2018618183 @default.
- W3137797907 cites W2019568643 @default.
- W3137797907 cites W2022343152 @default.
- W3137797907 cites W2024837178 @default.
- W3137797907 cites W2024851131 @default.
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- W3137797907 cites W2036206059 @default.
- W3137797907 cites W2037404352 @default.
- W3137797907 cites W2039617433 @default.
- W3137797907 cites W2044809902 @default.
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- W3137797907 doi "https://doi.org/10.3390/medicina57030273" @default.
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