Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137803232> ?p ?o ?g. }
- W3137803232 endingPage "0" @default.
- W3137803232 startingPage "0" @default.
- W3137803232 abstract "BACKGROUND: The expression of metalloproteinases (MMPs) in chronic rhinosinusitis with nasal polyposis (CRSwNP) was reviewed in order to investigate their possible use as therapeutical targets and/or biomarkers. METHODOLOGY: The differences between CRSwNP and normal controls or CRS without NP, as well as the effects of various treatments on MMPs, tissue inhibitors of MMPs (TIMPs) and MMP/TIMP ratios were considered as primary outcomes. Additional factors reported to affect MMP expression levels were noted as secondary outcomes. Data regarding inflammatory subtypes, patients’ clinical characteristics, controls, laboratory method(s) and origin of samples were also pooled. Studies on 10 or fewer patients or on specimens other than nasal and serum were excluded. RESULTS: Forty-three studies were included. Tissue sample origin, allergic rhinitis, smoking, infection, medication intake and primary or recurrent disease should be considered as confounding factors for MMP levels. MMP-1 and -7 were consistently found to be significantly higher in CRSwNP patients than controls. CRSwNP endotypes with distinctly different inflammation patterns seem to present similar MMP-related remodelling patterns. CONCLUSIONS: The existing literature has revealed several population and methodology related confounding factors and remains inconclusive regarding the roles of MMPs in CRSwNP pathophysiology and their possible clinical usefulness as biomarkers and therapeutical targets." @default.
- W3137803232 created "2021-03-29" @default.
- W3137803232 creator A5028120082 @default.
- W3137803232 creator A5049690064 @default.
- W3137803232 creator A5069750777 @default.
- W3137803232 creator A5071769539 @default.
- W3137803232 date "2021-03-01" @default.
- W3137803232 modified "2023-10-12" @default.
- W3137803232 title "Matrix metalloproteinases and chronic rhinosinusitis with nasal polyposis. Unravelling a puzzle through a systematic review" @default.
- W3137803232 cites W1526493787 @default.
- W3137803232 cites W1787121563 @default.
- W3137803232 cites W1849189332 @default.
- W3137803232 cites W1861039783 @default.
- W3137803232 cites W1897346030 @default.
- W3137803232 cites W1966428482 @default.
- W3137803232 cites W1966533061 @default.
- W3137803232 cites W1980607709 @default.
- W3137803232 cites W1984384517 @default.
- W3137803232 cites W1987044254 @default.
- W3137803232 cites W1988530965 @default.
- W3137803232 cites W1996267528 @default.
- W3137803232 cites W1998668235 @default.
- W3137803232 cites W2002286451 @default.
- W3137803232 cites W2009319731 @default.
- W3137803232 cites W2009817795 @default.
- W3137803232 cites W2012162957 @default.
- W3137803232 cites W2013350161 @default.
- W3137803232 cites W2013448594 @default.
- W3137803232 cites W2013495949 @default.
- W3137803232 cites W2020607200 @default.
- W3137803232 cites W2021359366 @default.
- W3137803232 cites W2021593215 @default.
- W3137803232 cites W2025894943 @default.
- W3137803232 cites W2036322339 @default.
- W3137803232 cites W2039230377 @default.
- W3137803232 cites W2042391758 @default.
- W3137803232 cites W2047805331 @default.
- W3137803232 cites W2055703852 @default.
- W3137803232 cites W2059498017 @default.
- W3137803232 cites W2065302886 @default.
- W3137803232 cites W2065753363 @default.
- W3137803232 cites W2066187497 @default.
- W3137803232 cites W2067631589 @default.
- W3137803232 cites W2072219890 @default.
- W3137803232 cites W2075151081 @default.
- W3137803232 cites W2075419705 @default.
- W3137803232 cites W2075672793 @default.
- W3137803232 cites W2079573726 @default.
- W3137803232 cites W2083223644 @default.
- W3137803232 cites W2095054225 @default.
- W3137803232 cites W2095311591 @default.
- W3137803232 cites W2097023891 @default.
- W3137803232 cites W2099873243 @default.
- W3137803232 cites W2100941609 @default.
- W3137803232 cites W2105088246 @default.
- W3137803232 cites W2108321829 @default.
- W3137803232 cites W2121317746 @default.
- W3137803232 cites W2124204692 @default.
- W3137803232 cites W2124741550 @default.
- W3137803232 cites W2127011978 @default.
- W3137803232 cites W2142554389 @default.
- W3137803232 cites W2148751505 @default.
- W3137803232 cites W2151136341 @default.
- W3137803232 cites W2155033588 @default.
- W3137803232 cites W2156541566 @default.
- W3137803232 cites W2161374186 @default.
- W3137803232 cites W2164032602 @default.
- W3137803232 cites W2173754270 @default.
- W3137803232 cites W2187269825 @default.
- W3137803232 cites W2289316671 @default.
- W3137803232 cites W2296494672 @default.
- W3137803232 cites W2305120036 @default.
- W3137803232 cites W2334060876 @default.
- W3137803232 cites W2334430987 @default.
- W3137803232 cites W2462860861 @default.
- W3137803232 cites W2507142851 @default.
- W3137803232 cites W2507811495 @default.
- W3137803232 cites W251085771 @default.
- W3137803232 cites W2544042101 @default.
- W3137803232 cites W2549183459 @default.
- W3137803232 cites W2555364178 @default.
- W3137803232 cites W2558893635 @default.
- W3137803232 cites W2567558689 @default.
- W3137803232 cites W2606319220 @default.
- W3137803232 cites W2613562874 @default.
- W3137803232 cites W2616395683 @default.
- W3137803232 cites W2743777215 @default.
- W3137803232 cites W2776484396 @default.
- W3137803232 cites W2783845858 @default.
- W3137803232 cites W2785586018 @default.
- W3137803232 cites W2789549529 @default.
- W3137803232 cites W2793569843 @default.
- W3137803232 cites W2809848124 @default.
- W3137803232 cites W2889858957 @default.
- W3137803232 cites W2890706776 @default.
- W3137803232 cites W2901367142 @default.
- W3137803232 cites W2901606332 @default.
- W3137803232 cites W2906663276 @default.