FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137805059> ?p ?o ?g. }

• W3137805059 endingPage "166127" @default.
• W3137805059 startingPage "166127" @default.
• W3137805059 abstract "Huntington's disease (HD) is an inherited, progressively debilitating disorder marked by prominent degeneration in striatal and cortical brain regions. HD is caused by (CAG) n repeat expansion in huntingtin ( HTT ) gene that translates into a mutant form of the ubiquitously present Huntingtin (HTT) protein. Extensive metabolic dysfunction coexisting with overt neuropathies has been evidenced in clinical and experimental settings of HD. Body weight loss despite normal to high caloric intake remains a critical determinant of the disease progression and a challenge for therapeutic interventions. In the present study, we intended to monitor the cellular and molecular perturbations in Drosophila, caused by pan-neuronal expression of mHTT (mutant Huntingtin) protein. We found aberrant transcription profile of key lipolytic and lipogenic genes in whole-body of the fly with disease progression. Interestingly, fatbody undergoes extensive alteration of vital cellular processes and eventually surrenders to increased apoptotic cell death in terminal stage of the disease. Extensive mitochondrial dysfunction from early disease stage along with calcium derangement at terminal stage were observed in fatbody, which contribute to its deteriorating integrity. All the mechanisms were monitored progressively, at different disease stages, and many alterations were documented in the early stage itself. Our study hence provides insight into the mechanisms through which neuronal expression of mHTT might be inflicting the profound systemic effects, specifically on lipid metabolism, and may open new therapeutic avenues for alleviation of the multidimensional disease. • Transcriptional dysregulation of brummer and lipin is evidenced in HD condition. • Fatbody undergoes apoptosis with disease progression. • Reduced mitochondrial membrane potential in fatbody contributes to its apoptosis. • Calcium derangement is evident at terminal stage in fatbody of HD flies." @default.
• W3137805059 created "2021-03-29" @default.
• W3137805059 creator A5008492541 @default.
• W3137805059 creator A5041362853 @default.
• W3137805059 date "2021-07-01" @default.
• W3137805059 modified "2023-10-04" @default.
• W3137805059 title "Deciphering the key mechanisms leading to alteration of lipid metabolism in Drosophila model of Huntington's disease" @default.
• W3137805059 cites W1643390591 @default.
• W3137805059 cites W1836009684 @default.
• W3137805059 cites W1887492302 @default.
• W3137805059 cites W1965703692 @default.
• W3137805059 cites W1966795273 @default.
• W3137805059 cites W1970083434 @default.
• W3137805059 cites W1972771185 @default.
• W3137805059 cites W1993418561 @default.
• W3137805059 cites W1998384937 @default.
• W3137805059 cites W1999267356 @default.
• W3137805059 cites W1999772546 @default.
• W3137805059 cites W2002055235 @default.
• W3137805059 cites W2005755833 @default.
• W3137805059 cites W2007158777 @default.
• W3137805059 cites W2007299852 @default.
• W3137805059 cites W2021134627 @default.
• W3137805059 cites W2027367467 @default.
• W3137805059 cites W2032459655 @default.
• W3137805059 cites W2043166587 @default.
• W3137805059 cites W2045143805 @default.
• W3137805059 cites W2053062221 @default.
• W3137805059 cites W2053985220 @default.
• W3137805059 cites W2059982830 @default.
• W3137805059 cites W2062793520 @default.
• W3137805059 cites W2079124378 @default.
• W3137805059 cites W2080858750 @default.
• W3137805059 cites W2083465475 @default.
• W3137805059 cites W2089441009 @default.
• W3137805059 cites W2090634740 @default.
• W3137805059 cites W2094890154 @default.
• W3137805059 cites W2096628067 @default.
• W3137805059 cites W2100621669 @default.
• W3137805059 cites W2107498496 @default.
• W3137805059 cites W2120132994 @default.
• W3137805059 cites W2121642311 @default.
• W3137805059 cites W2137938929 @default.
• W3137805059 cites W2137983766 @default.
• W3137805059 cites W2140639536 @default.
• W3137805059 cites W2146483495 @default.
• W3137805059 cites W2146826338 @default.
• W3137805059 cites W2146937117 @default.
• W3137805059 cites W2148130864 @default.
• W3137805059 cites W2148282025 @default.
• W3137805059 cites W2151190344 @default.
• W3137805059 cites W2157590258 @default.
• W3137805059 cites W2161311076 @default.
• W3137805059 cites W2169735361 @default.
• W3137805059 cites W2171155683 @default.
• W3137805059 cites W2254323678 @default.
• W3137805059 cites W2254701862 @default.
• W3137805059 cites W2411154620 @default.
• W3137805059 cites W2476292634 @default.
• W3137805059 cites W2500819717 @default.
• W3137805059 cites W2538552363 @default.
• W3137805059 cites W2794578067 @default.
• W3137805059 cites W2800906377 @default.
• W3137805059 cites W2810147710 @default.
• W3137805059 cites W2885288642 @default.
• W3137805059 cites W2887495242 @default.
• W3137805059 cites W2897765902 @default.
• W3137805059 cites W2902686872 @default.
• W3137805059 cites W2922867578 @default.
• W3137805059 cites W2950680801 @default.
• W3137805059 cites W2962246718 @default.
• W3137805059 cites W3001831138 @default.
• W3137805059 cites W3012270469 @default.
• W3137805059 cites W4250897434 @default.
• W3137805059 cites W48248669 @default.
• W3137805059 doi "https://doi.org/10.1016/j.bbadis.2021.166127" @default.
• W3137805059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33722743" @default.
• W3137805059 hasPublicationYear "2021" @default.
• W3137805059 type Work @default.
• W3137805059 sameAs 3137805059 @default.
• W3137805059 citedByCount "10" @default.
• W3137805059 countsByYear W31378050592021 @default.
• W3137805059 countsByYear W31378050592022 @default.
• W3137805059 countsByYear W31378050592023 @default.
• W3137805059 crossrefType "journal-article" @default.
• W3137805059 hasAuthorship W3137805059A5008492541 @default.
• W3137805059 hasAuthorship W3137805059A5041362853 @default.
• W3137805059 hasBestOaLocation W31378050591 @default.
• W3137805059 hasConcept C104317684 @default.
• W3137805059 hasConcept C111472728 @default.
• W3137805059 hasConcept C126322002 @default.
• W3137805059 hasConcept C138885662 @default.
• W3137805059 hasConcept C169760540 @default.
• W3137805059 hasConcept C18903297 @default.
• W3137805059 hasConcept C26517878 @default.
• W3137805059 hasConcept C2776041557 @default.
• W3137805059 hasConcept C2779134260 @default.
• W3137805059 hasConcept C2780104201 @default.

• next