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- W3137861182 abstract "In seeking to increase the library of fluorine containing adenine-derived carbocyclic nucleoside antiviral candidates, d -like and l -like 6′-fluoro-3-deazaneplanocin and its 3-bromo derivative lacking the 4′-hydroxylmethylene substituent ( 2 / 3 and 4 / 5 , respectively) are presented. Their synthesis was accomplished from d -ribose by developing a more facile precursor route than suggested by the literature. The 2 / 4 d -like pair displayed significant anti-filo virial properties while the enantiomeric l -like congeners 3 / 5 were inactive. Target compounds 2 / 4 also were active towards measles and norovirus. The effect of 2 / 4 is further evidence of the role fluoro-derived adenine carbocyclic nucleoside can play in antiviral drug discovery. Furthermore, the simplicity of their synthesis lends them to more efficacious analogs and to scale-up optimization. There were no other relevant antiviral properties for 2 / 3 and 4 / 5 (except BK polyomavirus for 3 / 5 )." @default.
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- W3137861182 date "2021-06-01" @default.
- W3137861182 modified "2023-10-18" @default.
- W3137861182 title "Enantiomeric 4′-truncated 6′-fluoro-3-deazaneplanocin and its 3-bromo derivative: Synthesis and antiviral properties, including Ebola and Marburg" @default.
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- W3137861182 doi "https://doi.org/10.1016/j.bmcl.2021.127985" @default.
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