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• W3137896317 abstract "The bioprospecting of secondary metabolites from endophytic fungi received great attention in the 1990s and 2000s, when the controversy around taxol production from Taxus spp. endophytes was at its height. Since then, hundreds of reports have described the isolation and characterization of putative secondary metabolites from endophytic fungi. However, only very few studies also report the genetic basis for these phenotypic observations. With low sequencing cost and fast sample turnaround, genetics- and genomics-based approaches have risen to become comprehensive approaches to study natural products from a wide-range of organisms, especially to elucidate underlying biosynthetic pathways. However, in the field of fungal endophyte biology, elucidation of biosynthetic pathways is still a major challenge. As a relatively poorly investigated group of microorganisms, even in the light of recent efforts to sequence more fungal genomes, such as the 1000 Fungal Genomes Project at the Joint Genome Institute (JGI), the basis for bioprospecting of enzymes and pathways from endophytic fungi is still rather slim. In this review we want to discuss the current approaches and tools used to associate phenotype and genotype to elucidate biosynthetic pathways of secondary metabolites in endophytic fungi through the lens of bioprospecting. This review will point out the reported successes and shortcomings, and discuss future directions in sampling, and genetics and genomics of endophytic fungi. Identifying responsible biosynthetic genes for the numerous secondary metabolites isolated from endophytic fungi opens the opportunity to explore the genetic potential of producer strains to discover novel secondary metabolites and enhance secondary metabolite production by metabolic engineering resulting in novel and more affordable medicines and food additives." @default.
• W3137896317 created "2021-03-29" @default.
• W3137896317 creator A5006246608 @default.
• W3137896317 creator A5019326558 @default.
• W3137896317 creator A5046531031 @default.
• W3137896317 date "2021-03-15" @default.
• W3137896317 modified "2023-09-24" @default.
• W3137896317 title "Current State and Future Directions of Genetics and Genomics of Endophytic Fungi for Bioprospecting Efforts" @default.
• W3137896317 cites W1675700228 @default.
• W3137896317 cites W1689654771 @default.
• W3137896317 cites W1965355928 @default.
• W3137896317 cites W1971384143 @default.
• W3137896317 cites W1976647189 @default.
• W3137896317 cites W1976913546 @default.
• W3137896317 cites W1978989082 @default.
• W3137896317 cites W1983031435 @default.
• W3137896317 cites W1989931500 @default.
• W3137896317 cites W1991805322 @default.
• W3137896317 cites W2003226432 @default.
• W3137896317 cites W2007055380 @default.
• W3137896317 cites W2010977379 @default.
• W3137896317 cites W2020475299 @default.
• W3137896317 cites W2021156563 @default.
• W3137896317 cites W2024878895 @default.
• W3137896317 cites W2025931030 @default.
• W3137896317 cites W2027118285 @default.
• W3137896317 cites W2029352277 @default.
• W3137896317 cites W2030207436 @default.
• W3137896317 cites W2032194047 @default.
• W3137896317 cites W2033464707 @default.
• W3137896317 cites W2034073820 @default.
• W3137896317 cites W2035693339 @default.
• W3137896317 cites W2040553139 @default.
• W3137896317 cites W2044531558 @default.
• W3137896317 cites W2053063880 @default.
• W3137896317 cites W2054896857 @default.
• W3137896317 cites W2055043387 @default.
• W3137896317 cites W2061803253 @default.
• W3137896317 cites W2070261551 @default.
• W3137896317 cites W2070917067 @default.
• W3137896317 cites W2074126222 @default.
• W3137896317 cites W2079187792 @default.
• W3137896317 cites W2086249423 @default.
• W3137896317 cites W2089501640 @default.
• W3137896317 cites W2095584660 @default.
• W3137896317 cites W2100975208 @default.
• W3137896317 cites W2102955607 @default.
• W3137896317 cites W2108638811 @default.
• W3137896317 cites W2109283849 @default.
• W3137896317 cites W2109728129 @default.
• W3137896317 cites W2126894726 @default.
• W3137896317 cites W2127977587 @default.
• W3137896317 cites W2132149755 @default.
• W3137896317 cites W2133339062 @default.
• W3137896317 cites W2135639274 @default.
• W3137896317 cites W2135673702 @default.
• W3137896317 cites W2139119508 @default.
• W3137896317 cites W2140725002 @default.
• W3137896317 cites W2144217762 @default.
• W3137896317 cites W2147589871 @default.
• W3137896317 cites W2147793579 @default.
• W3137896317 cites W2154579559 @default.
• W3137896317 cites W2155327450 @default.
• W3137896317 cites W2160122984 @default.
• W3137896317 cites W2169716710 @default.
• W3137896317 cites W2234173991 @default.
• W3137896317 cites W2264801741 @default.
• W3137896317 cites W2274375113 @default.
• W3137896317 cites W2285270389 @default.
• W3137896317 cites W2287869081 @default.
• W3137896317 cites W2304968031 @default.
• W3137896317 cites W2321580423 @default.
• W3137896317 cites W2334439554 @default.
• W3137896317 cites W2338882161 @default.
• W3137896317 cites W2396849069 @default.
• W3137896317 cites W2397729724 @default.
• W3137896317 cites W2410975458 @default.
• W3137896317 cites W2472341050 @default.
• W3137896317 cites W2479303073 @default.
• W3137896317 cites W2501913588 @default.
• W3137896317 cites W2503273054 @default.
• W3137896317 cites W2508672776 @default.
• W3137896317 cites W2513994765 @default.
• W3137896317 cites W2517883571 @default.
• W3137896317 cites W2573593701 @default.
• W3137896317 cites W2604372374 @default.
• W3137896317 cites W2604556059 @default.
• W3137896317 cites W2604636508 @default.
• W3137896317 cites W2608736608 @default.
• W3137896317 cites W2616688059 @default.
• W3137896317 cites W2626832796 @default.
• W3137896317 cites W2692027428 @default.
• W3137896317 cites W2742590491 @default.
• W3137896317 cites W2749186537 @default.
• W3137896317 cites W2749517821 @default.
• W3137896317 cites W2753325806 @default.
• W3137896317 cites W2757831920 @default.
• W3137896317 cites W2763141262 @default.
• W3137896317 cites W2765135073 @default.
• W3137896317 cites W2766193922 @default.

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