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• W3137897006 abstract "Abstract Endowing mesophilic microorganisms with high-temperature resistance is highly desirable for industrial microbial fermentation. Here, we report a cold-shock protein (CspL) that is an RNA chaperone protein from a lactate producing thermophile strain ( Bacillus coagulans 2–6), which is able to recombinantly confer strong high-temperature resistance to other microorganisms. Transgenic cspL expression massively enhanced high-temperature growth of Escherichia coli (a 2.4-fold biomass increase at 45 °C) and eukaryote Saccharomyces cerevisiae (a 2.6-fold biomass increase at 36 °C). Importantly, we also found that CspL promotes growth rates at normal temperatures. Mechanistically, bio-layer interferometry characterized CspL’s nucleotide-binding functions in vitro, while in vivo we used RNA-Seq and RIP-Seq to reveal CspL’s global effects on mRNA accumulation and CspL’s direct RNA binding targets, respectively. Thus, beyond establishing how a cold-shock protein chaperone provides high-temperature resistance, our study introduces a strategy that may facilitate industrial thermal fermentation." @default.
• W3137897006 created "2021-03-29" @default.
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• W3137897006 date "2021-03-16" @default.
• W3137897006 modified "2023-10-06" @default.
• W3137897006 title "A cold shock protein promotes high-temperature microbial growth through binding to diverse RNA species" @default.
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• W3137897006 doi "https://doi.org/10.1038/s41421-021-00246-5" @default.
• W3137897006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7966797" @default.
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