Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137897285> ?p ?o ?g. }
- W3137897285 abstract "Recently we showed that homoarginine supplementation confers kidney protection in diabetic mouse models. In this study we tested whether the protective effect of homoarginine is nitric oxide synthase-3 (NOS3)-independent in diabetic nephropathy (DN). Experiments were conducted in NOS3 deficient (NOS3-/- ) mice and their wild type littermate using multiple low doses of vehicle or streptozotocin and treated with homoarginine via drinking water for 24 weeks. Homoarginine supplementation for 24 weeks in diabetic NOS3-/- mice significantly attenuated albuminuria, increased blood urea nitrogen, histopathological changes and kidney fibrosis, kidney fibrotic markers, and kidney macrophage recruitment compared with vehicle-treated diabetic NOS3-/- mice. Furthermore, homoarginine supplementation restored kidney mitochondrial function following diabetes. Importantly, there were no significant changes in kidney NOS1 or NOS2 mRNA expression between all groups. In addition, homoarginine supplementation improved cardiac function and reduced cardiac fibrosis following diabetes. These data demonstrate that the protective effect of homoarginine is independent of NOS3, which will ultimately change our understanding of the mechanism(s) by which homoarginine induce renal and cardiac protection in DN. Homoarginine protective effect in DN could be mediated via improving mitochondrial function." @default.
- W3137897285 created "2021-03-29" @default.
- W3137897285 creator A5006788933 @default.
- W3137897285 creator A5011101977 @default.
- W3137897285 creator A5014467800 @default.
- W3137897285 creator A5031456843 @default.
- W3137897285 creator A5080285660 @default.
- W3137897285 creator A5091049868 @default.
- W3137897285 date "2021-03-01" @default.
- W3137897285 modified "2023-10-17" @default.
- W3137897285 title "Homoarginine ameliorates diabetic nephropathy independent of nitric oxide synthase‐3" @default.
- W3137897285 cites W1622243645 @default.
- W3137897285 cites W1967651820 @default.
- W3137897285 cites W1981149252 @default.
- W3137897285 cites W1983167541 @default.
- W3137897285 cites W1989851633 @default.
- W3137897285 cites W1999853237 @default.
- W3137897285 cites W2001370070 @default.
- W3137897285 cites W2001596360 @default.
- W3137897285 cites W2006128241 @default.
- W3137897285 cites W2019612137 @default.
- W3137897285 cites W2020871623 @default.
- W3137897285 cites W2024099384 @default.
- W3137897285 cites W2027866422 @default.
- W3137897285 cites W2029892143 @default.
- W3137897285 cites W2037160601 @default.
- W3137897285 cites W2048768264 @default.
- W3137897285 cites W2057843591 @default.
- W3137897285 cites W2059001601 @default.
- W3137897285 cites W2059558024 @default.
- W3137897285 cites W2059922794 @default.
- W3137897285 cites W2060505125 @default.
- W3137897285 cites W2066517990 @default.
- W3137897285 cites W2068362864 @default.
- W3137897285 cites W2069013650 @default.
- W3137897285 cites W2069981346 @default.
- W3137897285 cites W2074729919 @default.
- W3137897285 cites W2078725656 @default.
- W3137897285 cites W2079654264 @default.
- W3137897285 cites W2084613198 @default.
- W3137897285 cites W2086063084 @default.
- W3137897285 cites W2099080414 @default.
- W3137897285 cites W2100089732 @default.
- W3137897285 cites W2104848192 @default.
- W3137897285 cites W2113596742 @default.
- W3137897285 cites W2117438114 @default.
- W3137897285 cites W2130176433 @default.
- W3137897285 cites W2139947959 @default.
- W3137897285 cites W2149429610 @default.
- W3137897285 cites W2154896064 @default.
- W3137897285 cites W2155978870 @default.
- W3137897285 cites W2157891776 @default.
- W3137897285 cites W2161361699 @default.
- W3137897285 cites W2164460363 @default.
- W3137897285 cites W2165256339 @default.
- W3137897285 cites W2165803538 @default.
- W3137897285 cites W2207348770 @default.
- W3137897285 cites W2216845378 @default.
- W3137897285 cites W2282924142 @default.
- W3137897285 cites W2320407810 @default.
- W3137897285 cites W2324305741 @default.
- W3137897285 cites W2347172014 @default.
- W3137897285 cites W2400106959 @default.
- W3137897285 cites W2530369024 @default.
- W3137897285 cites W2535551906 @default.
- W3137897285 cites W2559144666 @default.
- W3137897285 cites W2581273592 @default.
- W3137897285 cites W2587141314 @default.
- W3137897285 cites W2592681966 @default.
- W3137897285 cites W2605529424 @default.
- W3137897285 cites W2733103256 @default.
- W3137897285 cites W2808220858 @default.
- W3137897285 cites W2810777483 @default.
- W3137897285 cites W2883897876 @default.
- W3137897285 cites W2888909588 @default.
- W3137897285 cites W2890018067 @default.
- W3137897285 cites W2896482747 @default.
- W3137897285 cites W2896744833 @default.
- W3137897285 cites W2899185552 @default.
- W3137897285 cites W2908467301 @default.
- W3137897285 cites W2924975078 @default.
- W3137897285 cites W997880930 @default.
- W3137897285 doi "https://doi.org/10.14814/phy2.14766" @default.
- W3137897285 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7955794" @default.
- W3137897285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33713581" @default.
- W3137897285 hasPublicationYear "2021" @default.
- W3137897285 type Work @default.
- W3137897285 sameAs 3137897285 @default.
- W3137897285 citedByCount "6" @default.
- W3137897285 countsByYear W31378972852021 @default.
- W3137897285 countsByYear W31378972852022 @default.
- W3137897285 crossrefType "journal-article" @default.
- W3137897285 hasAuthorship W3137897285A5006788933 @default.
- W3137897285 hasAuthorship W3137897285A5011101977 @default.
- W3137897285 hasAuthorship W3137897285A5014467800 @default.
- W3137897285 hasAuthorship W3137897285A5031456843 @default.
- W3137897285 hasAuthorship W3137897285A5080285660 @default.
- W3137897285 hasAuthorship W3137897285A5091049868 @default.
- W3137897285 hasBestOaLocation W31378972851 @default.
- W3137897285 hasConcept C126322002 @default.