Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137899752> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W3137899752 endingPage "721" @default.
- W3137899752 startingPage "715" @default.
- W3137899752 abstract "Abstract Aim The REACH and REACH‐2 trials investigated ramucirumab versus placebo in patients with advanced hepatocellular carcinoma (HCC). Ascites is common in HCC and is associated with poorer outcomes. This exploratory, pooled meta‐analysis of patients with baseline α ‐fetoprotein (AFP) ≥400 ng/ml investigated outcomes by treatment‐emergent (TE) ascites in REACH and REACH‐2. Methods A pooled meta‐analysis of independent patient data for participants ( N = 542) with baseline AFP ≥400 ng/ml (stratified by study) from REACH and REACH‐2 was carried out. Overall survival (OS) and progression‐free survival (PFS) were evaluated by Kaplan–Meier estimator, and OS further assessed by Cox models. The effect of TE ascites on OS was evaluated by multivariate Cox models. Results Treatment‐emergent ascites developed in 66 patients (20.9%) in the ramucirumab group and 33 patients (14.8%) in the placebo group. When adjusted for treatment duration, the incidence rates per 100 patient‐years of any grade TE ascites were 59.1 and 71.9 for the ramucirumab and placebo groups, respectively, and the incidence of grade ≥3 TE ascites were 13.4 and 19.6, respectively. Treatment‐emergent ascites was associated with TE hypoalbuminemia (odds ratio 4.9; 95% confidence interval 2.5‒9.3), but not TE proteinuria or hypertension. One patient discontinued ramucirumab treatment due to TE ascites. Ramucirumab treatment improved OS and PFS compared with placebo, irrespective of TE ascites. Conclusions When adjusted for treatment duration, the incidence of TE ascites was no higher in patients who received ramucirumab than in those who received placebo. Ramucirumab was well tolerated and provided a survival benefit irrespective of the development of TE ascites." @default.
- W3137899752 created "2021-03-29" @default.
- W3137899752 creator A5009529288 @default.
- W3137899752 creator A5022537134 @default.
- W3137899752 creator A5032900701 @default.
- W3137899752 creator A5046542801 @default.
- W3137899752 creator A5060428080 @default.
- W3137899752 creator A5073989429 @default.
- W3137899752 creator A5075605825 @default.
- W3137899752 creator A5077044527 @default.
- W3137899752 creator A5083536113 @default.
- W3137899752 creator A5086023651 @default.
- W3137899752 creator A5088566246 @default.
- W3137899752 date "2021-05-04" @default.
- W3137899752 modified "2023-10-13" @default.
- W3137899752 title "Ramucirumab in patients with advanced hepatocellular carcinoma and elevated <i>α</i> ‐fetoprotein: Outcomes by treatment‐emergent ascites" @default.
- W3137899752 cites W1828082159 @default.
- W3137899752 cites W1973058318 @default.
- W3137899752 cites W2012975578 @default.
- W3137899752 cites W2063744431 @default.
- W3137899752 cites W2560499218 @default.
- W3137899752 cites W2606367731 @default.
- W3137899752 cites W2809889937 @default.
- W3137899752 cites W2908573150 @default.
- W3137899752 cites W2990602950 @default.
- W3137899752 cites W3030195763 @default.
- W3137899752 doi "https://doi.org/10.1111/hepr.13638" @default.
- W3137899752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33743189" @default.
- W3137899752 hasPublicationYear "2021" @default.
- W3137899752 type Work @default.
- W3137899752 sameAs 3137899752 @default.
- W3137899752 citedByCount "5" @default.
- W3137899752 countsByYear W31378997522022 @default.
- W3137899752 crossrefType "journal-article" @default.
- W3137899752 hasAuthorship W3137899752A5009529288 @default.
- W3137899752 hasAuthorship W3137899752A5022537134 @default.
- W3137899752 hasAuthorship W3137899752A5032900701 @default.
- W3137899752 hasAuthorship W3137899752A5046542801 @default.
- W3137899752 hasAuthorship W3137899752A5060428080 @default.
- W3137899752 hasAuthorship W3137899752A5073989429 @default.
- W3137899752 hasAuthorship W3137899752A5075605825 @default.
- W3137899752 hasAuthorship W3137899752A5077044527 @default.
- W3137899752 hasAuthorship W3137899752A5083536113 @default.
- W3137899752 hasAuthorship W3137899752A5086023651 @default.
- W3137899752 hasAuthorship W3137899752A5088566246 @default.
- W3137899752 hasBestOaLocation W31378997521 @default.
- W3137899752 hasConcept C120665830 @default.
- W3137899752 hasConcept C121332964 @default.
- W3137899752 hasConcept C126322002 @default.
- W3137899752 hasConcept C142724271 @default.
- W3137899752 hasConcept C204787440 @default.
- W3137899752 hasConcept C27081682 @default.
- W3137899752 hasConcept C2776694085 @default.
- W3137899752 hasConcept C2778019345 @default.
- W3137899752 hasConcept C2779551604 @default.
- W3137899752 hasConcept C2780496750 @default.
- W3137899752 hasConcept C44249647 @default.
- W3137899752 hasConcept C50382708 @default.
- W3137899752 hasConcept C61511704 @default.
- W3137899752 hasConcept C71924100 @default.
- W3137899752 hasConcept C90924648 @default.
- W3137899752 hasConceptScore W3137899752C120665830 @default.
- W3137899752 hasConceptScore W3137899752C121332964 @default.
- W3137899752 hasConceptScore W3137899752C126322002 @default.
- W3137899752 hasConceptScore W3137899752C142724271 @default.
- W3137899752 hasConceptScore W3137899752C204787440 @default.
- W3137899752 hasConceptScore W3137899752C27081682 @default.
- W3137899752 hasConceptScore W3137899752C2776694085 @default.
- W3137899752 hasConceptScore W3137899752C2778019345 @default.
- W3137899752 hasConceptScore W3137899752C2779551604 @default.
- W3137899752 hasConceptScore W3137899752C2780496750 @default.
- W3137899752 hasConceptScore W3137899752C44249647 @default.
- W3137899752 hasConceptScore W3137899752C50382708 @default.
- W3137899752 hasConceptScore W3137899752C61511704 @default.
- W3137899752 hasConceptScore W3137899752C71924100 @default.
- W3137899752 hasConceptScore W3137899752C90924648 @default.
- W3137899752 hasFunder F4320307758 @default.
- W3137899752 hasIssue "6" @default.
- W3137899752 hasLocation W31378997521 @default.
- W3137899752 hasOpenAccess W3137899752 @default.
- W3137899752 hasPrimaryLocation W31378997521 @default.
- W3137899752 hasRelatedWork W1477040914 @default.
- W3137899752 hasRelatedWork W2005697460 @default.
- W3137899752 hasRelatedWork W2312849920 @default.
- W3137899752 hasRelatedWork W2768121504 @default.
- W3137899752 hasRelatedWork W2791398175 @default.
- W3137899752 hasRelatedWork W2894890258 @default.
- W3137899752 hasRelatedWork W2924151097 @default.
- W3137899752 hasRelatedWork W3199274710 @default.
- W3137899752 hasRelatedWork W4286002222 @default.
- W3137899752 hasRelatedWork W4376872470 @default.
- W3137899752 hasVolume "51" @default.
- W3137899752 isParatext "false" @default.
- W3137899752 isRetracted "false" @default.
- W3137899752 magId "3137899752" @default.
- W3137899752 workType "article" @default.