FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137915827> ?p ?o ?g. }

• W3137915827 endingPage "3601" @default.
• W3137915827 startingPage "3594" @default.
• W3137915827 abstract "Coronaviruses have been causing pandemic situations across the globe for the past two decades and the focus is on identifying suitable novel targets for antivirals and vaccine development. SARS-CoV-2 encodes a small hydrophobic envelope (E) protein that mediates envelope formation, budding, replication, and release of progeny viruses from the host. Through this study, the SARS-CoV-2 E protein is studied for its open and closed state and focused in identifying antiviral herbs used in traditional medicine practices for COVID-19 infections. In this study using computational tools, we docked the shortlisted phytochemicals with the envelope protein of the SARS-CoV-2 virus and the results hint that these compounds interact with the pore-lining residues. The molecular level understanding of the open state is considered and the active inhibitors from the phytochemicals of Ayurvedic medicinal plants from Withania somnifera. We have thus identified a potential phytochemical compound that directly binds with the pore region of the E protein and thereby blocks its channel activity. Blocking the ion channel activity of E protein is directly related to the inhibition of virus replication. The study shows encouraging results on the usage of these phytochemicals in the treatment/management of SARS-CoV-2 infection." @default.
• W3137915827 created "2021-03-29" @default.
• W3137915827 creator A5075926625 @default.
• W3137915827 date "2021-06-01" @default.
• W3137915827 modified "2023-10-14" @default.
• W3137915827 title "Structure insights of SARS-CoV-2 open state envelope protein and inhibiting through active phytochemical of ayurvedic medicinal plants from Withania somnifera" @default.
• W3137915827 cites W1566763301 @default.
• W3137915827 cites W1689651690 @default.
• W3137915827 cites W1977754086 @default.
• W3137915827 cites W2003662468 @default.
• W3137915827 cites W2036693329 @default.
• W3137915827 cites W2055043387 @default.
• W3137915827 cites W2117905193 @default.
• W3137915827 cites W2124733207 @default.
• W3137915827 cites W2403769980 @default.
• W3137915827 cites W2749555747 @default.
• W3137915827 cites W2966860041 @default.
• W3137915827 cites W2995563458 @default.
• W3137915827 cites W3008922838 @default.
• W3137915827 cites W3011815529 @default.
• W3137915827 cites W3014912119 @default.
• W3137915827 cites W3020644773 @default.
• W3137915827 cites W3022121885 @default.
• W3137915827 cites W3022285953 @default.
• W3137915827 cites W3023894494 @default.
• W3137915827 cites W3027002382 @default.
• W3137915827 cites W3036355841 @default.
• W3137915827 cites W3039633850 @default.
• W3137915827 cites W3047842123 @default.
• W3137915827 cites W3047996214 @default.
• W3137915827 cites W3102648521 @default.
• W3137915827 cites W3105514776 @default.
• W3137915827 cites W3111103775 @default.
• W3137915827 cites W3112462835 @default.
• W3137915827 cites W3120469917 @default.
• W3137915827 cites W868176235 @default.
• W3137915827 doi "https://doi.org/10.1016/j.sjbs.2021.03.036" @default.
• W3137915827 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7970802" @default.
• W3137915827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33758570" @default.
• W3137915827 hasPublicationYear "2021" @default.
• W3137915827 type Work @default.
• W3137915827 sameAs 3137915827 @default.
• W3137915827 citedByCount "6" @default.
• W3137915827 countsByYear W31379158272021 @default.
• W3137915827 countsByYear W31379158272022 @default.
• W3137915827 countsByYear W31379158272023 @default.
• W3137915827 crossrefType "journal-article" @default.
• W3137915827 hasAuthorship W3137915827A5075926625 @default.
• W3137915827 hasBestOaLocation W31379158271 @default.
• W3137915827 hasConcept C140704245 @default.
• W3137915827 hasConcept C142724271 @default.
• W3137915827 hasConcept C159047783 @default.
• W3137915827 hasConcept C195475562 @default.
• W3137915827 hasConcept C204787440 @default.
• W3137915827 hasConcept C2522874641 @default.
• W3137915827 hasConcept C2779158651 @default.
• W3137915827 hasConcept C2780069950 @default.
• W3137915827 hasConcept C55493867 @default.
• W3137915827 hasConcept C556039675 @default.
• W3137915827 hasConcept C59822182 @default.
• W3137915827 hasConcept C70721500 @default.
• W3137915827 hasConcept C71924100 @default.
• W3137915827 hasConcept C86803240 @default.
• W3137915827 hasConcept C97380033 @default.
• W3137915827 hasConceptScore W3137915827C140704245 @default.
• W3137915827 hasConceptScore W3137915827C142724271 @default.
• W3137915827 hasConceptScore W3137915827C159047783 @default.
• W3137915827 hasConceptScore W3137915827C195475562 @default.
• W3137915827 hasConceptScore W3137915827C204787440 @default.
• W3137915827 hasConceptScore W3137915827C2522874641 @default.
• W3137915827 hasConceptScore W3137915827C2779158651 @default.
• W3137915827 hasConceptScore W3137915827C2780069950 @default.
• W3137915827 hasConceptScore W3137915827C55493867 @default.
• W3137915827 hasConceptScore W3137915827C556039675 @default.
• W3137915827 hasConceptScore W3137915827C59822182 @default.
• W3137915827 hasConceptScore W3137915827C70721500 @default.
• W3137915827 hasConceptScore W3137915827C71924100 @default.
• W3137915827 hasConceptScore W3137915827C86803240 @default.
• W3137915827 hasConceptScore W3137915827C97380033 @default.
• W3137915827 hasFunder F4320324553 @default.
• W3137915827 hasIssue "6" @default.
• W3137915827 hasLocation W31379158271 @default.
• W3137915827 hasLocation W31379158272 @default.
• W3137915827 hasOpenAccess W3137915827 @default.
• W3137915827 hasPrimaryLocation W31379158271 @default.
• W3137915827 hasRelatedWork W2302345710 @default.
• W3137915827 hasRelatedWork W2737943774 @default.
• W3137915827 hasRelatedWork W2802858223 @default.
• W3137915827 hasRelatedWork W2924965784 @default.
• W3137915827 hasRelatedWork W2992225012 @default.
• W3137915827 hasRelatedWork W3096512210 @default.
• W3137915827 hasRelatedWork W3148556330 @default.
• W3137915827 hasRelatedWork W3200165450 @default.
• W3137915827 hasRelatedWork W2182736081 @default.
• W3137915827 hasRelatedWork W2182853506 @default.
• W3137915827 hasVolume "28" @default.
• W3137915827 isParatext "false" @default.
• W3137915827 isRetracted "false" @default.

• next