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- W3137916538 abstract "Azetidines represent one of the most important four-membered heterocycles used in organic synthesis and medicinal chemistry. The reactivity of azetidines is driven by a considerable ring strain, while at the same the ring is significantly more stable than that of related aziridines, which translates into both facile handling and unique reactivity that can be triggered under appropriate reaction conditions. Recently, remarkable advances in the chemistry and reactivity of azetidines have been reported. In this review, we provide an overview of the synthesis, reactivity and application of azetidines that have been published in the last years with a focus on the most recent advances, trends and future directions. The review is organized by the methods of synthesis of azetidines and the reaction type used for functionalization of azetidines. Finally, recent examples of using azetidines as motifs in drug discovery, polymerization and chiral templates are discussed." @default.
- W3137916538 created "2021-03-29" @default.
- W3137916538 creator A5068601986 @default.
- W3137916538 creator A5089374559 @default.
- W3137916538 date "2021-01-01" @default.
- W3137916538 modified "2023-10-07" @default.
- W3137916538 title "Recent advances in the synthesis and reactivity of azetidines: strain-driven character of the four-membered heterocycle" @default.
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- W3137916538 doi "https://doi.org/10.1039/d1ob00061f" @default.
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