FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137916557> ?p ?o ?g. }

• W3137916557 endingPage "616" @default.
• W3137916557 startingPage "610" @default.
• W3137916557 abstract "Selective cyclooxygenase-1 (COX-1) inhibition has got into the spotlight with the discovery of COX-1 upregulation in various cancers and the cardioprotective role of COX-1 in control of thrombocyte aggregation. Yet, COX-1-selective inhibitors are poorly explored. Thus, three series of quinazoline derivatives were prepared and tested for their potential inhibitory activity toward COX-1 and COX-2. Of the prepared compounds, 11 exhibited interesting COX-1 selectivity, with 8 compounds being totally COX-1-selective. The IC50 value of the best quinazoline inhibitor was 64 nM. The structural features ensuring COX-1 selectivity were elucidated using in silico modeling." @default.
• W3137916557 created "2021-03-29" @default.
• W3137916557 creator A5003055836 @default.
• W3137916557 creator A5030157058 @default.
• W3137916557 creator A5035659131 @default.
• W3137916557 creator A5064693860 @default.
• W3137916557 creator A5070095076 @default.
• W3137916557 creator A5073617254 @default.
• W3137916557 date "2021-03-12" @default.
• W3137916557 modified "2023-10-11" @default.
• W3137916557 title "Synthesis, Inhibitory Activity, and <i>In Silico</i> Modeling of Selective COX-1 Inhibitors with a Quinazoline Core" @default.
• W3137916557 cites W1969846083 @default.
• W3137916557 cites W1970195934 @default.
• W3137916557 cites W1972912421 @default.
• W3137916557 cites W1978890358 @default.
• W3137916557 cites W1983177410 @default.
• W3137916557 cites W2030850720 @default.
• W3137916557 cites W2038060152 @default.
• W3137916557 cites W2044049931 @default.
• W3137916557 cites W2049959755 @default.
• W3137916557 cites W2054303552 @default.
• W3137916557 cites W2070481035 @default.
• W3137916557 cites W2098577478 @default.
• W3137916557 cites W2111134372 @default.
• W3137916557 cites W2145742835 @default.
• W3137916557 cites W2146306600 @default.
• W3137916557 cites W2169392317 @default.
• W3137916557 cites W2344425030 @default.
• W3137916557 cites W2415746792 @default.
• W3137916557 cites W2467969544 @default.
• W3137916557 cites W2608800928 @default.
• W3137916557 cites W2622401404 @default.
• W3137916557 cites W2665259114 @default.
• W3137916557 cites W2740117282 @default.
• W3137916557 cites W2742556528 @default.
• W3137916557 cites W2770186014 @default.
• W3137916557 cites W2792961161 @default.
• W3137916557 cites W2802797222 @default.
• W3137916557 cites W2896100746 @default.
• W3137916557 cites W2901466986 @default.
• W3137916557 cites W2968673361 @default.
• W3137916557 cites W2972389532 @default.
• W3137916557 cites W4256099920 @default.
• W3137916557 doi "https://doi.org/10.1021/acsmedchemlett.1c00004" @default.
• W3137916557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8040043" @default.
• W3137916557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33854702" @default.
• W3137916557 hasPublicationYear "2021" @default.
• W3137916557 type Work @default.
• W3137916557 sameAs 3137916557 @default.
• W3137916557 citedByCount "9" @default.
• W3137916557 countsByYear W31379165572022 @default.
• W3137916557 countsByYear W31379165572023 @default.
• W3137916557 crossrefType "journal-article" @default.
• W3137916557 hasAuthorship W3137916557A5003055836 @default.
• W3137916557 hasAuthorship W3137916557A5030157058 @default.
• W3137916557 hasAuthorship W3137916557A5035659131 @default.
• W3137916557 hasAuthorship W3137916557A5064693860 @default.
• W3137916557 hasAuthorship W3137916557A5070095076 @default.
• W3137916557 hasAuthorship W3137916557A5073617254 @default.
• W3137916557 hasBestOaLocation W31379165571 @default.
• W3137916557 hasConcept C104317684 @default.
• W3137916557 hasConcept C118792377 @default.
• W3137916557 hasConcept C126322002 @default.
• W3137916557 hasConcept C161790260 @default.
• W3137916557 hasConcept C17077164 @default.
• W3137916557 hasConcept C181199279 @default.
• W3137916557 hasConcept C185592680 @default.
• W3137916557 hasConcept C202751555 @default.
• W3137916557 hasConcept C21951064 @default.
• W3137916557 hasConcept C2775905019 @default.
• W3137916557 hasConcept C2777031258 @default.
• W3137916557 hasConcept C2777752497 @default.
• W3137916557 hasConcept C2778866207 @default.
• W3137916557 hasConcept C2779689624 @default.
• W3137916557 hasConcept C55493867 @default.
• W3137916557 hasConcept C71924100 @default.
• W3137916557 hasConcept C98274493 @default.
• W3137916557 hasConceptScore W3137916557C104317684 @default.
• W3137916557 hasConceptScore W3137916557C118792377 @default.
• W3137916557 hasConceptScore W3137916557C126322002 @default.
• W3137916557 hasConceptScore W3137916557C161790260 @default.
• W3137916557 hasConceptScore W3137916557C17077164 @default.
• W3137916557 hasConceptScore W3137916557C181199279 @default.
• W3137916557 hasConceptScore W3137916557C185592680 @default.
• W3137916557 hasConceptScore W3137916557C202751555 @default.
• W3137916557 hasConceptScore W3137916557C21951064 @default.
• W3137916557 hasConceptScore W3137916557C2775905019 @default.
• W3137916557 hasConceptScore W3137916557C2777031258 @default.
• W3137916557 hasConceptScore W3137916557C2777752497 @default.
• W3137916557 hasConceptScore W3137916557C2778866207 @default.
• W3137916557 hasConceptScore W3137916557C2779689624 @default.
• W3137916557 hasConceptScore W3137916557C55493867 @default.
• W3137916557 hasConceptScore W3137916557C71924100 @default.
• W3137916557 hasConceptScore W3137916557C98274493 @default.
• W3137916557 hasFunder F4320321005 @default.
• W3137916557 hasFunder F4320321181 @default.
• W3137916557 hasIssue "4" @default.
• W3137916557 hasLocation W31379165571 @default.

• next