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• W3137971314 abstract "SUMMARY The dense network of capillaries composed of capillary endothelial cells (cECs) and pericytes lies in close proximity to all neurons, ideally positioning it to sense neuro/glial-derived compounds that regulate regional and global cerebral perfusion. The membrane potential (V M ) of vascular cells serves as the essential output in this scenario, linking brain activity to vascular function. The ATP-sensitive K + channel (K ATP ) is a key regulator of vascular V M in other beds, but whether brain capillaries possess functional K ATP channels remains unknown. Here, we demonstrate that brain capillary ECs and pericytes express K ATP channels that robustly control V M . We further show that the endogenous mediator adenosine acts through A 2A receptors and the G s /cAMP/PKA pathway to activate capillary K ATP channels. Moreover, K ATP channel stimulation in vivo causes vasodilation and increases cerebral blood flow (CBF). These findings establish the presence of K ATP channels in cECs and pericytes and suggest their significant influence on CBF. HIGHLIGHTS Capillary network cellular components—endothelial cells and pericytes—possess functional K ATP channels. Activation of K ATP channels causes profound hyperpolarization of capillary cell membranes. Capillary K ATP channels are activated by exogenous adenosine via A 2A receptors and cAMP-dependent protein kinase. K ATP channel activation by adenosine or synthetic openers increases cerebral blood flow." @default.
• W3137971314 created "2021-03-29" @default.
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• W3137971314 date "2021-03-13" @default.
• W3137971314 modified "2023-09-26" @default.
• W3137971314 title "Electro-Metabolic Sensing Through Capillary ATP-Sensitive K+ Channels and Adenosine to Control Cerebral Blood Flow" @default.
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• W3137971314 doi "https://doi.org/10.1101/2021.03.12.435152" @default.
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