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• W3138013352 abstract "Type 2 diabetes (T2D) is a multifactorial disease caused by a complex interplay between environmental risk factors and genetic predisposition. To date, a total of 10 single nucleotide polymorphism (SNPs) have been associated with pediatric-onset T2D in Mexicans, with a small individual effect size. A genetic risk score (GRS) that combines these SNPs could serve as a predictor of the risk for pediatric-onset T2D.To assess the clinical utility of a GRS that combines 10 SNPs to improve risk prediction of pediatric-onset T2D in Mexicans.This case-control study included 97 individuals with pediatric-onset T2D and 84 controls below 18 years old without T2D. Information regarding family history of T2D, demographics, perinatal risk factors, anthropometric measurements, biochemical variables, lifestyle, and fitness scores were then obtained. Moreover, 10 single nucleotide polymorphisms (SNPs) previously associated with pediatric-onset T2D in Mexicans were genotyped. The GRS was calculated by summing the 10 risk alleles. Pediatric-onset T2D risk variance was assessed using multivariable logistic regression models and the area under the receiver operating characteristic curve (AUC).The body mass index Z-score (Z-BMI) [odds ratio (OR) = 1.7; p = 0.009] and maternal history of T2D (OR = 7.1; p < 0.001) were found to be independently associated with pediatric-onset T2D. No association with other clinical risk factors was observed. The GRS also showed a significant association with pediatric-onset T2D (OR = 1.3 per risk allele; p = 0.006). The GRS, clinical risk factors, and GRS plus clinical risk factors had an AUC of 0.66 (95% CI 0.56-0.75), 0.72 (95% CI 0.62-0.81), and 0.78 (95% CI 0.70-0.87), respectively (p < 0.01).The GRS based on 10 SNPs was associated with pediatric-onset T2D in Mexicans and improved its prediction with modest significance. However, clinical factors, such the Z-BMI and family history of T2D, continue to have the highest predictive utility in this population." @default.
• W3138013352 created "2021-03-29" @default.
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• W3138013352 date "2021-03-12" @default.
• W3138013352 modified "2023-10-06" @default.
• W3138013352 title "A Genetic Risk Score Improves the Prediction of Type 2 Diabetes Mellitus in Mexican Youths but Has Lower Predictive Utility Compared With Non-Genetic Factors" @default.
• W3138013352 cites W110489919 @default.
• W3138013352 cites W1966254895 @default.
• W3138013352 cites W1977454091 @default.
• W3138013352 cites W1986410584 @default.
• W3138013352 cites W1989429766 @default.
• W3138013352 cites W1990311034 @default.
• W3138013352 cites W1992054180 @default.
• W3138013352 cites W1993785867 @default.
• W3138013352 cites W2003132592 @default.
• W3138013352 cites W2012355763 @default.
• W3138013352 cites W2013153623 @default.
• W3138013352 cites W2014803359 @default.
• W3138013352 cites W2021513620 @default.
• W3138013352 cites W2022905671 @default.
• W3138013352 cites W2030539248 @default.
• W3138013352 cites W2030570682 @default.
• W3138013352 cites W2032213172 @default.
• W3138013352 cites W2032908038 @default.
• W3138013352 cites W2057282532 @default.
• W3138013352 cites W2073211589 @default.
• W3138013352 cites W2075393588 @default.
• W3138013352 cites W2084482942 @default.
• W3138013352 cites W2096691922 @default.
• W3138013352 cites W2097843904 @default.
• W3138013352 cites W2100236190 @default.
• W3138013352 cites W2104005244 @default.
• W3138013352 cites W2104549677 @default.
• W3138013352 cites W2107222217 @default.
• W3138013352 cites W2109167239 @default.
• W3138013352 cites W2114328140 @default.
• W3138013352 cites W2117238405 @default.
• W3138013352 cites W2119445047 @default.
• W3138013352 cites W2125863327 @default.
• W3138013352 cites W2126100846 @default.
• W3138013352 cites W2126447572 @default.
• W3138013352 cites W2135984480 @default.
• W3138013352 cites W2141070261 @default.
• W3138013352 cites W2141642891 @default.
• W3138013352 cites W2144852094 @default.
• W3138013352 cites W2145325541 @default.
• W3138013352 cites W2146264121 @default.
• W3138013352 cites W2148749248 @default.
• W3138013352 cites W2154279407 @default.
• W3138013352 cites W2155536385 @default.
• W3138013352 cites W2165796078 @default.
• W3138013352 cites W2167048252 @default.
• W3138013352 cites W2177538943 @default.
• W3138013352 cites W2189923872 @default.
• W3138013352 cites W2332951586 @default.
• W3138013352 cites W2428840270 @default.
• W3138013352 cites W2518067145 @default.
• W3138013352 cites W2528989516 @default.
• W3138013352 cites W2579282755 @default.
• W3138013352 cites W2587448612 @default.
• W3138013352 cites W2593422591 @default.
• W3138013352 cites W2605419178 @default.
• W3138013352 cites W2605820757 @default.
• W3138013352 cites W2616613824 @default.
• W3138013352 cites W2617316722 @default.
• W3138013352 cites W2621290111 @default.
• W3138013352 cites W2752530178 @default.
• W3138013352 cites W2782180738 @default.
• W3138013352 cites W2783817204 @default.
• W3138013352 cites W2786899395 @default.
• W3138013352 cites W2791531453 @default.
• W3138013352 cites W2806213947 @default.
• W3138013352 cites W2806610290 @default.
• W3138013352 cites W2901630626 @default.
• W3138013352 cites W2909204873 @default.
• W3138013352 cites W2913692862 @default.
• W3138013352 cites W2918625078 @default.
• W3138013352 cites W2951938323 @default.
• W3138013352 cites W2979970094 @default.
• W3138013352 cites W2987437294 @default.
• W3138013352 cites W2990505594 @default.
• W3138013352 cites W3001541216 @default.
• W3138013352 cites W3004683659 @default.
• W3138013352 cites W3011788268 @default.
• W3138013352 cites W3016191918 @default.
• W3138013352 cites W4235479662 @default.
• W3138013352 doi "https://doi.org/10.3389/fendo.2021.647864" @default.
• W3138013352 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7994893" @default.
• W3138013352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33776940" @default.
• W3138013352 hasPublicationYear "2021" @default.
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