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• W3138014468 abstract "Lead, a known neurotoxicant, has previously received attention in Parkinson's disease (PD) research, but epidemiologic studies have been limited in sample size and findings are equivocal. We generated two methylation-based biomarkers for cumulative tibia and patella bone-measured lead exposure in 1528 PD patients and 1169 controls. PD status was associated with increased levels of the DNAm biomarker for tibia-lead levels. We estimated a meta-OR for PD of 1.89 per unit DNAm tibia-lead increase (95% CI 1.59, 2.24; p = 8.1E-13). The current study supports the notion that chronic and long-term lead exposure tracked via DNAm may contribute to PD pathogenesis." @default.
• W3138014468 created "2021-03-29" @default.
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• W3138014468 date "2021-03-22" @default.
• W3138014468 modified "2023-10-17" @default.
• W3138014468 title "DNA methylation biomarker for cumulative lead exposure is associated with Parkinson’s disease" @default.
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• W3138014468 doi "https://doi.org/10.1186/s13148-021-01051-3" @default.
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