Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138069999> ?p ?o ?g. }
- W3138069999 endingPage "768.e5" @default.
- W3138069999 startingPage "753" @default.
- W3138069999 abstract "Viral infections induce a conserved host response distinct from bacterial infections. We hypothesized that the conserved response is associated with disease severity and is distinct between patients with different outcomes. To test this, we integrated 4,780 blood transcriptome profiles from patients aged 0 to 90 years infected with one of 16 viruses, including SARS-CoV-2, Ebola, chikungunya, and influenza, across 34 cohorts from 18 countries, and single-cell RNA sequencing profiles of 702,970 immune cells from 289 samples across three cohorts. Severe viral infection was associated with increased hematopoiesis, myelopoiesis, and myeloid-derived suppressor cells. We identified protective and detrimental gene modules that defined distinct trajectories associated with mild versus severe outcomes. The interferon response was decoupled from the protective host response in patients with severe outcomes. These findings were consistent, irrespective of age and virus, and provide insights to accelerate the development of diagnostics and host-directed therapies to improve global pandemic preparedness." @default.
- W3138069999 created "2021-03-29" @default.
- W3138069999 creator A5006424559 @default.
- W3138069999 creator A5009566947 @default.
- W3138069999 creator A5014329530 @default.
- W3138069999 creator A5014721790 @default.
- W3138069999 creator A5030219128 @default.
- W3138069999 creator A5032990625 @default.
- W3138069999 creator A5033124739 @default.
- W3138069999 creator A5050280430 @default.
- W3138069999 creator A5051029833 @default.
- W3138069999 creator A5051852173 @default.
- W3138069999 creator A5057075908 @default.
- W3138069999 creator A5060832423 @default.
- W3138069999 creator A5066576056 @default.
- W3138069999 creator A5073047339 @default.
- W3138069999 creator A5083763463 @default.
- W3138069999 creator A5084801933 @default.
- W3138069999 creator A5086494262 @default.
- W3138069999 date "2021-04-01" @default.
- W3138069999 modified "2023-10-14" @default.
- W3138069999 title "Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity across viruses" @default.
- W3138069999 cites W1966858538 @default.
- W3138069999 cites W1971524600 @default.
- W3138069999 cites W1984601694 @default.
- W3138069999 cites W1989708898 @default.
- W3138069999 cites W1992285484 @default.
- W3138069999 cites W1997651223 @default.
- W3138069999 cites W2005948700 @default.
- W3138069999 cites W2014165627 @default.
- W3138069999 cites W2036897871 @default.
- W3138069999 cites W2046830231 @default.
- W3138069999 cites W2052633053 @default.
- W3138069999 cites W2069089843 @default.
- W3138069999 cites W2069869279 @default.
- W3138069999 cites W2072769614 @default.
- W3138069999 cites W2083525619 @default.
- W3138069999 cites W2084734424 @default.
- W3138069999 cites W2091841926 @default.
- W3138069999 cites W2107665951 @default.
- W3138069999 cites W2114325274 @default.
- W3138069999 cites W2120076861 @default.
- W3138069999 cites W2126867009 @default.
- W3138069999 cites W2139113799 @default.
- W3138069999 cites W2143314736 @default.
- W3138069999 cites W2144544583 @default.
- W3138069999 cites W2145686583 @default.
- W3138069999 cites W2149378058 @default.
- W3138069999 cites W2154571798 @default.
- W3138069999 cites W2169456326 @default.
- W3138069999 cites W2174786259 @default.
- W3138069999 cites W2179438025 @default.
- W3138069999 cites W2218326748 @default.
- W3138069999 cites W2279836332 @default.
- W3138069999 cites W2285903333 @default.
- W3138069999 cites W2346069395 @default.
- W3138069999 cites W2474277182 @default.
- W3138069999 cites W2531419784 @default.
- W3138069999 cites W2554114075 @default.
- W3138069999 cites W2561322596 @default.
- W3138069999 cites W2576671703 @default.
- W3138069999 cites W2579523860 @default.
- W3138069999 cites W2592811885 @default.
- W3138069999 cites W2735414283 @default.
- W3138069999 cites W2771319431 @default.
- W3138069999 cites W2789285316 @default.
- W3138069999 cites W2793824022 @default.
- W3138069999 cites W2803990310 @default.
- W3138069999 cites W2805554952 @default.
- W3138069999 cites W2805822392 @default.
- W3138069999 cites W2888101674 @default.
- W3138069999 cites W2889037189 @default.
- W3138069999 cites W2889326414 @default.
- W3138069999 cites W2897215926 @default.
- W3138069999 cites W2899588238 @default.
- W3138069999 cites W2901800871 @default.
- W3138069999 cites W2907514116 @default.
- W3138069999 cites W2910671640 @default.
- W3138069999 cites W2915104822 @default.
- W3138069999 cites W2944073176 @default.
- W3138069999 cites W2944826857 @default.
- W3138069999 cites W2949362157 @default.
- W3138069999 cites W2954575981 @default.
- W3138069999 cites W2964477617 @default.
- W3138069999 cites W2998837808 @default.
- W3138069999 cites W2999051239 @default.
- W3138069999 cites W3010267838 @default.
- W3138069999 cites W3011382870 @default.
- W3138069999 cites W3016288338 @default.
- W3138069999 cites W3020655115 @default.
- W3138069999 cites W3034168389 @default.
- W3138069999 cites W3041842588 @default.
- W3138069999 cites W3041960835 @default.
- W3138069999 cites W3047168254 @default.
- W3138069999 cites W3047402958 @default.
- W3138069999 cites W3047880178 @default.
- W3138069999 cites W3048531412 @default.
- W3138069999 cites W3093604087 @default.