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- W3138103631 abstract "The new Coronavirus Disease 2019 (COVID-19), caused by the virus SARS-CoV-2, is characterized by a broad spectrum of clinical manifestations and different degrees of severity, ranging from asymptomatic/mild symptoms to Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Failure (MOF), potentially life-threatening The clinical course of COVID-19 includes usually three stages The first stage, defined as “early infection”, occurs at the time of virus infiltration in the lung parenchyma, via the interaction of SARS-CoV-2 with the angiotensin-converting enzyme 2 (ACE2) in ciliated bronchial epithelial cells The second step, the “pulmonary phase”, is characterized by viral pneumonia with localized inflammation within the lung The third stage, the “hyperinflammation phase”, is the most severe because of the development of a systemic inflammation and cytokine overproduction leading to ARDS and MOF In this complex contest, the laboratory can provide a strong support for the appropriate clinical management of COVID-19 for diagnosis, prognosis, and monitoring of the disease Current research focuses on the potential role of immune and/or inflammatory biomarkers as useful tools in COVID-19 patients In this narrative review, we will provide an overview about some of these biomarkers: procalcitonin, mid regional-pro adrenomedullin, presepsin, soluble fms-like tyrosine kinase 1/placental growth factor, ACE2, interleukin-6 and vitamin D © 2020 Biomedia All rights reserved" @default.
- W3138103631 created "2021-03-29" @default.
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- W3138103631 date "2020-01-01" @default.
- W3138103631 modified "2023-09-23" @default.
- W3138103631 title "SARS-CoV-2: New perspectives for the clinical laboratory diagnostics" @default.
- W3138103631 doi "https://doi.org/10.19186/bc_2020.082" @default.
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