Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138125859> ?p ?o ?g. }
- W3138125859 endingPage "27" @default.
- W3138125859 startingPage "16" @default.
- W3138125859 abstract "Poly-peptide molecules have shown promising applications in drug delivery and tumor targeting. A series of tumor homing peptides were designed by exhaustively sampling low energy geometrical basins of amino acids at specific sites of a peptide molecule to induce a conformational lock. This peptide library was pruned to a limited set of eight molecules, employing electrostatic interactions, docking, and molecular dynamics simulations. These designed and optimized peptides were synthesized and tested on various cell lines, including breast cancer (MDA-MB-231), cervical cancer (HeLa), osteosarcoma (U2-OS), and non-cancerous mammary epithelial cells (MCF-10A) using confocal microscopy and flow cytometry. Peptides show differential uptake in cancerous MDA-MB-231, HeLa, U2-OS, and non-cancerous MCF-10A cells. Confocal imaging verified their ability to penetrate even in 3D tumorospheres of MDA-MB-231 cells. Further, experiments of mitochondrial membrane potential depolarization and Caspase-3 activation confirmed that their cytotoxic effects are by apoptosis. Homing ability of the designed peptides in in vivo system and fluorescence imaging with clinical samples of human origin have further confirmed that the in vitro studies are qualitatively identical and quantitatively comparable in their ability to selectively recognize tumor cells. Overall, we present a roadmap for the functional programming of peptide-based homing and penetrating molecules that can perform selective tumor targeting." @default.
- W3138125859 created "2021-03-29" @default.
- W3138125859 creator A5003942574 @default.
- W3138125859 creator A5011656808 @default.
- W3138125859 creator A5027195331 @default.
- W3138125859 creator A5035772808 @default.
- W3138125859 creator A5039152436 @default.
- W3138125859 creator A5039850431 @default.
- W3138125859 creator A5049476291 @default.
- W3138125859 creator A5069164179 @default.
- W3138125859 creator A5073357844 @default.
- W3138125859 creator A5077338813 @default.
- W3138125859 date "2021-05-01" @default.
- W3138125859 modified "2023-10-09" @default.
- W3138125859 title "Geometry encoded functional programming of tumor homing peptides for targeted drug delivery" @default.
- W3138125859 cites W1560153159 @default.
- W3138125859 cites W1586022877 @default.
- W3138125859 cites W1667478348 @default.
- W3138125859 cites W1818070918 @default.
- W3138125859 cites W1860382351 @default.
- W3138125859 cites W1867778453 @default.
- W3138125859 cites W1868748105 @default.
- W3138125859 cites W1968851765 @default.
- W3138125859 cites W1977295091 @default.
- W3138125859 cites W1995855261 @default.
- W3138125859 cites W1999213903 @default.
- W3138125859 cites W2002659318 @default.
- W3138125859 cites W2005425959 @default.
- W3138125859 cites W2006304896 @default.
- W3138125859 cites W2007258535 @default.
- W3138125859 cites W2008000140 @default.
- W3138125859 cites W2008757142 @default.
- W3138125859 cites W2015642465 @default.
- W3138125859 cites W2015966835 @default.
- W3138125859 cites W2025816743 @default.
- W3138125859 cites W2032467518 @default.
- W3138125859 cites W2034188120 @default.
- W3138125859 cites W2042143311 @default.
- W3138125859 cites W2042962257 @default.
- W3138125859 cites W2046968083 @default.
- W3138125859 cites W2049902088 @default.
- W3138125859 cites W2050426579 @default.
- W3138125859 cites W2051024211 @default.
- W3138125859 cites W2056760423 @default.
- W3138125859 cites W2056894945 @default.
- W3138125859 cites W2058600606 @default.
- W3138125859 cites W2058762558 @default.
- W3138125859 cites W2060315328 @default.
- W3138125859 cites W2083182472 @default.
- W3138125859 cites W2084039931 @default.
- W3138125859 cites W2089663038 @default.
- W3138125859 cites W2091462162 @default.
- W3138125859 cites W2094469836 @default.
- W3138125859 cites W2096868396 @default.
- W3138125859 cites W2105300288 @default.
- W3138125859 cites W2105668062 @default.
- W3138125859 cites W2108713158 @default.
- W3138125859 cites W2109741979 @default.
- W3138125859 cites W2117150402 @default.
- W3138125859 cites W2136471260 @default.
- W3138125859 cites W2139290875 @default.
- W3138125859 cites W2159793822 @default.
- W3138125859 cites W2163326536 @default.
- W3138125859 cites W2167376542 @default.
- W3138125859 cites W2168812241 @default.
- W3138125859 cites W2171268876 @default.
- W3138125859 cites W2172888731 @default.
- W3138125859 cites W2173690323 @default.
- W3138125859 cites W2334550978 @default.
- W3138125859 cites W2413001086 @default.
- W3138125859 cites W2514906115 @default.
- W3138125859 cites W2749089988 @default.
- W3138125859 cites W2759023450 @default.
- W3138125859 cites W2762042556 @default.
- W3138125859 cites W2765680226 @default.
- W3138125859 cites W2790275804 @default.
- W3138125859 cites W2793935997 @default.
- W3138125859 cites W2805901293 @default.
- W3138125859 cites W2806596889 @default.
- W3138125859 cites W2806631624 @default.
- W3138125859 cites W2890167612 @default.
- W3138125859 cites W2909584502 @default.
- W3138125859 cites W2910981131 @default.
- W3138125859 cites W2974890122 @default.
- W3138125859 cites W3037328286 @default.
- W3138125859 cites W3048711862 @default.
- W3138125859 doi "https://doi.org/10.1016/j.jconrel.2021.03.010" @default.
- W3138125859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33722612" @default.
- W3138125859 hasPublicationYear "2021" @default.
- W3138125859 type Work @default.
- W3138125859 sameAs 3138125859 @default.
- W3138125859 citedByCount "32" @default.
- W3138125859 countsByYear W31381258592021 @default.
- W3138125859 countsByYear W31381258592022 @default.
- W3138125859 countsByYear W31381258592023 @default.
- W3138125859 crossrefType "journal-article" @default.
- W3138125859 hasAuthorship W3138125859A5003942574 @default.
- W3138125859 hasAuthorship W3138125859A5011656808 @default.