Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138131556> ?p ?o ?g. }
- W3138131556 abstract "Q fever is caused by the obligate intracellular bacterium, Coxiella burnetii , a designated potential agent of bioterrorism because of its route of transmission, resistance to disinfectants, and low infectious dose. The only vaccine licensed for human use is Q-VAX ® (Seqirus, licensed in Australia), a formalin-inactivated whole-cell vaccine, which produces severe local and systemic reactogenic responses in previously sensitized individuals. Accordingly, the U.S. Food and Drug Administration and other regulatory bodies around the world, have been reluctant to approve Q-VAX for widespread use. To obviate these adverse reactions, we prepared recombinant protein subunit vaccine candidates containing purified CBU1910, CBU0307, CBU0545, CBU0612, CBU0891, and CBU1398 proteins and TLR triagonist adjuvants. TLR triagonist adjuvants combine different TLR agonists to enhance immune responses to vaccine antigens. We tested both the protective efficacy and reactogenicity of our vaccine candidates in Hartley guinea pigs using intratracheal infection with live C. burnetii . While all of our candidates showed varying degrees of protection during challenge, local reactogenic responses were significantly reduced for one of our vaccine candidates when compared with a formalin-inactivated whole-cell vaccine. Our findings show that subunit vaccines combined with novel TLR triagonist adjuvants can generate protective immunity to C. burnetii infection while reducing reactogenic responses." @default.
- W3138131556 created "2021-03-29" @default.
- W3138131556 creator A5003697551 @default.
- W3138131556 creator A5008005518 @default.
- W3138131556 creator A5009096637 @default.
- W3138131556 creator A5010232221 @default.
- W3138131556 creator A5012650406 @default.
- W3138131556 creator A5018504020 @default.
- W3138131556 creator A5018551147 @default.
- W3138131556 creator A5036695894 @default.
- W3138131556 creator A5042837010 @default.
- W3138131556 creator A5044549524 @default.
- W3138131556 creator A5046574532 @default.
- W3138131556 creator A5066316506 @default.
- W3138131556 creator A5079381482 @default.
- W3138131556 creator A5088688665 @default.
- W3138131556 creator A5090533058 @default.
- W3138131556 date "2021-03-17" @default.
- W3138131556 modified "2023-10-15" @default.
- W3138131556 title "Subunit Vaccines Using TLR Triagonist Combination Adjuvants Provide Protection Against Coxiella burnetii While Minimizing Reactogenic Responses" @default.
- W3138131556 cites W1625397436 @default.
- W3138131556 cites W1963886255 @default.
- W3138131556 cites W1964828595 @default.
- W3138131556 cites W1994624777 @default.
- W3138131556 cites W1997657977 @default.
- W3138131556 cites W2003055084 @default.
- W3138131556 cites W2010132397 @default.
- W3138131556 cites W2023102863 @default.
- W3138131556 cites W2039976095 @default.
- W3138131556 cites W2065666472 @default.
- W3138131556 cites W2066017115 @default.
- W3138131556 cites W2074730676 @default.
- W3138131556 cites W2078731100 @default.
- W3138131556 cites W2081718624 @default.
- W3138131556 cites W2090928701 @default.
- W3138131556 cites W2103304202 @default.
- W3138131556 cites W2106248075 @default.
- W3138131556 cites W2107450325 @default.
- W3138131556 cites W2113420637 @default.
- W3138131556 cites W2122258958 @default.
- W3138131556 cites W2123620378 @default.
- W3138131556 cites W2128897591 @default.
- W3138131556 cites W2129169740 @default.
- W3138131556 cites W2130477547 @default.
- W3138131556 cites W2131634519 @default.
- W3138131556 cites W2134715322 @default.
- W3138131556 cites W2138694950 @default.
- W3138131556 cites W2140241830 @default.
- W3138131556 cites W2143578012 @default.
- W3138131556 cites W2144733364 @default.
- W3138131556 cites W2146047473 @default.
- W3138131556 cites W2156229754 @default.
- W3138131556 cites W2159112596 @default.
- W3138131556 cites W2159280765 @default.
- W3138131556 cites W2168711505 @default.
- W3138131556 cites W2326627549 @default.
- W3138131556 cites W2394725514 @default.
- W3138131556 cites W2618210811 @default.
- W3138131556 cites W2739154332 @default.
- W3138131556 cites W2810052293 @default.
- W3138131556 cites W2811486373 @default.
- W3138131556 cites W2897049729 @default.
- W3138131556 cites W2901746667 @default.
- W3138131556 cites W2903651569 @default.
- W3138131556 cites W2915674652 @default.
- W3138131556 cites W2931431950 @default.
- W3138131556 cites W2947061558 @default.
- W3138131556 cites W2954248714 @default.
- W3138131556 cites W2971866010 @default.
- W3138131556 cites W2983930755 @default.
- W3138131556 cites W2996913199 @default.
- W3138131556 cites W3026795897 @default.
- W3138131556 cites W3030947224 @default.
- W3138131556 doi "https://doi.org/10.3389/fimmu.2021.653092" @default.
- W3138131556 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8010241" @default.
- W3138131556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33815413" @default.
- W3138131556 hasPublicationYear "2021" @default.
- W3138131556 type Work @default.
- W3138131556 sameAs 3138131556 @default.
- W3138131556 citedByCount "13" @default.
- W3138131556 countsByYear W31381315562021 @default.
- W3138131556 countsByYear W31381315562022 @default.
- W3138131556 countsByYear W31381315562023 @default.
- W3138131556 crossrefType "journal-article" @default.
- W3138131556 hasAuthorship W3138131556A5003697551 @default.
- W3138131556 hasAuthorship W3138131556A5008005518 @default.
- W3138131556 hasAuthorship W3138131556A5009096637 @default.
- W3138131556 hasAuthorship W3138131556A5010232221 @default.
- W3138131556 hasAuthorship W3138131556A5012650406 @default.
- W3138131556 hasAuthorship W3138131556A5018504020 @default.
- W3138131556 hasAuthorship W3138131556A5018551147 @default.
- W3138131556 hasAuthorship W3138131556A5036695894 @default.
- W3138131556 hasAuthorship W3138131556A5042837010 @default.
- W3138131556 hasAuthorship W3138131556A5044549524 @default.
- W3138131556 hasAuthorship W3138131556A5046574532 @default.
- W3138131556 hasAuthorship W3138131556A5066316506 @default.
- W3138131556 hasAuthorship W3138131556A5079381482 @default.
- W3138131556 hasAuthorship W3138131556A5088688665 @default.
- W3138131556 hasAuthorship W3138131556A5090533058 @default.
- W3138131556 hasBestOaLocation W31381315561 @default.