Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138156942> ?p ?o ?g. }
- W3138156942 endingPage "491" @default.
- W3138156942 startingPage "491" @default.
- W3138156942 abstract "One of the prevailing perceptions regarding the ageing of cells and organisms is the intracellular gradual accumulation of oxidatively damaged macromolecules, leading to the decline of cell and organ function (free radical theory of ageing). This chemically undefined material known as “lipofuscin,” “ceroid,” or “age pigment” is mainly formed through unregulated and nonspecific oxidative modifications of cellular macromolecules that are induced by highly reactive free radicals. A necessary precondition for reactive free radical generation and lipofuscin formation is the intracellular availability of ferrous iron (Fe2+) (“labile iron”), catalyzing the conversion of weak oxidants such as peroxides, to extremely reactive ones like hydroxyl (HO•) or alcoxyl (RO•) radicals. If the oxidized materials remain unrepaired for extended periods of time, they can be further oxidized to generate ultimate over-oxidized products that are unable to be repaired, degraded, or exocytosed by the relevant cellular systems. Additionally, over-oxidized materials might inactivate cellular protection and repair mechanisms, thus allowing for futile cycles of increasingly rapid lipofuscin accumulation. In this review paper, we present evidence that the modulation of the labile iron pool distribution by nutritional or pharmacological means represents a hitherto unappreciated target for hampering lipofuscin accumulation and cellular ageing." @default.
- W3138156942 created "2021-03-29" @default.
- W3138156942 creator A5016235730 @default.
- W3138156942 creator A5024724084 @default.
- W3138156942 creator A5031810437 @default.
- W3138156942 creator A5033662443 @default.
- W3138156942 creator A5048058498 @default.
- W3138156942 creator A5052903401 @default.
- W3138156942 creator A5053901718 @default.
- W3138156942 creator A5062517767 @default.
- W3138156942 date "2021-03-21" @default.
- W3138156942 modified "2023-10-02" @default.
- W3138156942 title "Implication of Dietary Iron-Chelating Bioactive Compounds in Molecular Mechanisms of Oxidative Stress-Induced Cell Ageing" @default.
- W3138156942 cites W139157314 @default.
- W3138156942 cites W1489844805 @default.
- W3138156942 cites W1940436875 @default.
- W3138156942 cites W1941424948 @default.
- W3138156942 cites W1963688739 @default.
- W3138156942 cites W1963874808 @default.
- W3138156942 cites W1963931238 @default.
- W3138156942 cites W1965389900 @default.
- W3138156942 cites W1966160892 @default.
- W3138156942 cites W1967507703 @default.
- W3138156942 cites W1970924670 @default.
- W3138156942 cites W1971755855 @default.
- W3138156942 cites W1972958434 @default.
- W3138156942 cites W1973530425 @default.
- W3138156942 cites W1974313178 @default.
- W3138156942 cites W1974906548 @default.
- W3138156942 cites W1977800604 @default.
- W3138156942 cites W1982481909 @default.
- W3138156942 cites W1982900915 @default.
- W3138156942 cites W1983594275 @default.
- W3138156942 cites W1983673827 @default.
- W3138156942 cites W1983887515 @default.
- W3138156942 cites W1984496481 @default.
- W3138156942 cites W1986110431 @default.
- W3138156942 cites W1992344724 @default.
- W3138156942 cites W1995205742 @default.
- W3138156942 cites W1995731966 @default.
- W3138156942 cites W1997175480 @default.
- W3138156942 cites W1999627180 @default.
- W3138156942 cites W2000490880 @default.
- W3138156942 cites W2003410494 @default.
- W3138156942 cites W2004314923 @default.
- W3138156942 cites W2007244362 @default.
- W3138156942 cites W2008124325 @default.
- W3138156942 cites W2013287222 @default.
- W3138156942 cites W2018027031 @default.
- W3138156942 cites W2018168104 @default.
- W3138156942 cites W2020978481 @default.
- W3138156942 cites W2021294790 @default.
- W3138156942 cites W2021358858 @default.
- W3138156942 cites W2026517317 @default.
- W3138156942 cites W2028585334 @default.
- W3138156942 cites W2033221504 @default.
- W3138156942 cites W2033898136 @default.
- W3138156942 cites W2036229829 @default.
- W3138156942 cites W2039035664 @default.
- W3138156942 cites W2042793067 @default.
- W3138156942 cites W2043978278 @default.
- W3138156942 cites W2049566430 @default.
- W3138156942 cites W2051243842 @default.
- W3138156942 cites W2051291293 @default.
- W3138156942 cites W2053145973 @default.
- W3138156942 cites W2055512409 @default.
- W3138156942 cites W2055752218 @default.
- W3138156942 cites W2056537429 @default.
- W3138156942 cites W2056614663 @default.
- W3138156942 cites W2060292237 @default.
- W3138156942 cites W2062241029 @default.
- W3138156942 cites W2068337326 @default.
- W3138156942 cites W2068907822 @default.
- W3138156942 cites W2072007125 @default.
- W3138156942 cites W2072738759 @default.
- W3138156942 cites W2074171762 @default.
- W3138156942 cites W2077450385 @default.
- W3138156942 cites W2080378774 @default.
- W3138156942 cites W2084556573 @default.
- W3138156942 cites W2085128107 @default.
- W3138156942 cites W2089006481 @default.
- W3138156942 cites W2094776609 @default.
- W3138156942 cites W2104221917 @default.
- W3138156942 cites W2110934787 @default.
- W3138156942 cites W2112392983 @default.
- W3138156942 cites W2114364424 @default.
- W3138156942 cites W2116346328 @default.
- W3138156942 cites W2116817816 @default.
- W3138156942 cites W2126525177 @default.
- W3138156942 cites W2130458932 @default.
- W3138156942 cites W2130641115 @default.
- W3138156942 cites W2132826785 @default.
- W3138156942 cites W2140068099 @default.
- W3138156942 cites W2140665078 @default.
- W3138156942 cites W2144053989 @default.
- W3138156942 cites W2152251039 @default.
- W3138156942 cites W2158115535 @default.
- W3138156942 cites W2159052592 @default.