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- W3138166439 endingPage "831" @default.
- W3138166439 startingPage "831" @default.
- W3138166439 abstract "Clinical cytogenetic studies in horses have been ongoing for over half a century and clearly demonstrate that chromosomal disorders are among the most common non-infectious causes of decreased fertility, infertility, and congenital defects. Large-scale cytogenetic surveys show that almost 30% of horses with reproductive or developmental problems have chromosome aberrations, whereas abnormal karyotypes are found in only 2–5% of the general population. Among the many chromosome abnormalities reported in the horse, most are unique or rare. However, all surveys agree that there are two recurrent conditions: X-monosomy and SRY-negative XY male-to-female sex reversal, making up approximately 35% and 11% of all chromosome abnormalities, respectively. The two are signature conditions for the horse and rare or absent in other domestic species. The progress in equine genomics and the development of molecular tools, have qualitatively improved clinical cytogenetics today, allowing for refined characterization of aberrations and understanding the underlying molecular mechanisms. While cutting-edge genomics tools promise further improvements in chromosome analysis, they will not entirely replace traditional cytogenetics, which still is the most straightforward, cost-effective, and fastest approach for the initial evaluation of potential breeding animals and horses with reproductive or developmental disorders." @default.
- W3138166439 created "2021-03-29" @default.
- W3138166439 creator A5050810845 @default.
- W3138166439 creator A5083034928 @default.
- W3138166439 date "2021-03-16" @default.
- W3138166439 modified "2023-09-26" @default.
- W3138166439 title "Horse Clinical Cytogenetics: Recurrent Themes and Novel Findings" @default.
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