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• W3138209120 abstract "Circular RNAs (circRNAs) are novel non-coding RNAs, which show abnormal expression in several diseases, such as atherosclerosis (AS). The purpose of the present study was to reveal the association between hsa_circ_0004543 and AS. In the present study, hsa_circ_0004543 was overexpressed in human umbilical vein endothelial cells (HUVECs) induced by oxidized low-density lipoprotein (oxLDL). Inhibition of hsa_circ_0004543 expression facilitated the proliferation, migration, and invasion of HUVECs and significantly reduced their apoptotic rate following treatment with oxLDL. Furthermore, silencing of hsa_circ_0004543 activated the PI3K/AKT/NOS3 pathway in oxLDL-induced HUVECs. Collectively, these results demonstrated that hsa_circ_0004543 may play a vital role in the development of AS and affect the proliferation of HUVECs, providing a potential target for treating endothelial cell damage in AS." @default.
• W3138209120 created "2021-03-29" @default.
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• W3138209120 date "2021-03-24" @default.
• W3138209120 modified "2023-10-04" @default.
• W3138209120 title "Downregulation of hsa_circ_0004543 Activates oxLDL-Induced Vascular Endothelial Cell Proliferation and Angiogenesis" @default.
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• W3138209120 doi "https://doi.org/10.3389/fgene.2021.632164" @default.
• W3138209120 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8024642" @default.
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