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• W3138284180 abstract "This study explores the functions of exosomes derived from human breast milk (HBM) in vivo and in vitro. HBM-derived exosomes were collected from healthy lactating mothers. In vitro analysis were divided into five groups: (1) a control with no added agents, (2) exosomes added, (3) stimulated with lipopolysaccharide (LPS), (4) pretreated with exosomes and stimulated with LPS, and (5) pretreated with exosome-free HBM and stimulated with LPS. For in vivo analysis, mouse pups were randomly assigned to four groups: (1) a control group of breastfed pups, (2) necrotizing enterocolitis-induced (NEC) pups, (3) pups pretreated with HBM-derived exosomes 6 h before being induced by NEC, and (4) pups pretreated with exosome-free HBM 6 h before NEC induction. Expression of zonula occludens-1 (ZO-1), claudin-1, and occludin were decreased in groups 3 and 5. In the animal model, mice pups in group 3 showed milder intestinal tissue injury than those in group 2 or 4 and had lower levels of the proinflammatory cytokines and higher levels of epithelial tight-junction proteins than groups 2 and 4. HBM-derived exosomes exert beneficial effects in preventing NEC by reducing inflammation and injury to the intestinal epithelium as well as by restoring intestinal tight-junction proteins." @default.
• W3138284180 created "2021-03-29" @default.
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• W3138284180 date "2021-03-17" @default.
• W3138284180 modified "2023-10-01" @default.
• W3138284180 title "Human breast milk-derived exosomes may help maintain intestinal epithelial barrier integrity" @default.
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• W3138284180 doi "https://doi.org/10.1038/s41390-021-01449-y" @default.
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