Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138285868> ?p ?o ?g. }
- W3138285868 abstract "Amyloid β (Aβ) is a crucial component of drusen, the hallmark of the early stage of age-related macular degeneration (AMD), and can cause retinal pigment epithelium (RPE) cell damage through activation of the inflammatory response. MicroRNAs play a critical role in inflammation. However, the mechanism underlying the effect of microRNAs on the NLRP3 inflammasome induced by Aβ remains poorly understood. In the present study, we demonstrated that Aβ1-40-mediated RPE damage by inducing a decrease in endogenous miR-191-5p expression. This led to the upregulation of its target gene, C/EBPβ. C/EBPβ acts as a transcription factor for NLRP3, promotes its transcription, and upregulates the downstream inflammatory factors Caspase-1 and IL-1β. Correspondingly, overexpression of miR-191-5p alleviated RPE cell injury by suppressing inflammation. The present study elucidates a novel transcriptional regulatory mechanism of the NLRP3 inflammasome. Our findings suggest an anti-inflammatory effect of miR-191-5p in Aβ1-40-induced RPE impairment, shedding light on novel preventive or therapeutic approaches for AMD-associated RPE impairment." @default.
- W3138285868 created "2021-03-29" @default.
- W3138285868 creator A5005383517 @default.
- W3138285868 creator A5007000017 @default.
- W3138285868 creator A5011388287 @default.
- W3138285868 creator A5049986768 @default.
- W3138285868 creator A5052821016 @default.
- W3138285868 creator A5062875840 @default.
- W3138285868 creator A5070607262 @default.
- W3138285868 creator A5073303207 @default.
- W3138285868 creator A5074920934 @default.
- W3138285868 date "2021-03-14" @default.
- W3138285868 modified "2023-10-14" @default.
- W3138285868 title "MicroRNA‐191‐5p ameliorates amyloid‐β <sub>1‐40</sub> –mediated retinal pigment epithelium cell injury by suppressing the NLRP3 inflammasome pathway" @default.
- W3138285868 cites W1000233140 @default.
- W3138285868 cites W1606082686 @default.
- W3138285868 cites W1922878222 @default.
- W3138285868 cites W1965942744 @default.
- W3138285868 cites W1981220178 @default.
- W3138285868 cites W1985144223 @default.
- W3138285868 cites W2003101845 @default.
- W3138285868 cites W2013029756 @default.
- W3138285868 cites W2017136158 @default.
- W3138285868 cites W2026570544 @default.
- W3138285868 cites W2029827106 @default.
- W3138285868 cites W2033662964 @default.
- W3138285868 cites W2037013087 @default.
- W3138285868 cites W2040237389 @default.
- W3138285868 cites W2048178760 @default.
- W3138285868 cites W2050438215 @default.
- W3138285868 cites W2058052477 @default.
- W3138285868 cites W2059563381 @default.
- W3138285868 cites W2075017815 @default.
- W3138285868 cites W2078209460 @default.
- W3138285868 cites W2083667486 @default.
- W3138285868 cites W2086919198 @default.
- W3138285868 cites W2110733383 @default.
- W3138285868 cites W2111586778 @default.
- W3138285868 cites W2123957215 @default.
- W3138285868 cites W2128163368 @default.
- W3138285868 cites W2131607023 @default.
- W3138285868 cites W2136501493 @default.
- W3138285868 cites W2160226180 @default.
- W3138285868 cites W2161068194 @default.
- W3138285868 cites W2161818169 @default.
- W3138285868 cites W2261057593 @default.
- W3138285868 cites W2264982258 @default.
- W3138285868 cites W2468095299 @default.
- W3138285868 cites W2488026107 @default.
- W3138285868 cites W2517641217 @default.
- W3138285868 cites W2522321843 @default.
- W3138285868 cites W2567271475 @default.
- W3138285868 cites W2598907887 @default.
- W3138285868 cites W2600484542 @default.
- W3138285868 cites W2621343448 @default.
- W3138285868 cites W2742108006 @default.
- W3138285868 cites W2762593269 @default.
- W3138285868 cites W2782813514 @default.
- W3138285868 cites W2791371574 @default.
- W3138285868 cites W2792692975 @default.
- W3138285868 cites W2890743650 @default.
- W3138285868 cites W2934765971 @default.
- W3138285868 cites W2940697822 @default.
- W3138285868 cites W2948718688 @default.
- W3138285868 cites W2958258302 @default.
- W3138285868 cites W2964855216 @default.
- W3138285868 cites W2967478340 @default.
- W3138285868 cites W2968276030 @default.
- W3138285868 cites W2978325544 @default.
- W3138285868 doi "https://doi.org/10.1096/fj.202000645rr" @default.
- W3138285868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33715208" @default.
- W3138285868 hasPublicationYear "2021" @default.
- W3138285868 type Work @default.
- W3138285868 sameAs 3138285868 @default.
- W3138285868 citedByCount "7" @default.
- W3138285868 countsByYear W31382858682021 @default.
- W3138285868 countsByYear W31382858682022 @default.
- W3138285868 countsByYear W31382858682023 @default.
- W3138285868 crossrefType "journal-article" @default.
- W3138285868 hasAuthorship W3138285868A5005383517 @default.
- W3138285868 hasAuthorship W3138285868A5007000017 @default.
- W3138285868 hasAuthorship W3138285868A5011388287 @default.
- W3138285868 hasAuthorship W3138285868A5049986768 @default.
- W3138285868 hasAuthorship W3138285868A5052821016 @default.
- W3138285868 hasAuthorship W3138285868A5062875840 @default.
- W3138285868 hasAuthorship W3138285868A5070607262 @default.
- W3138285868 hasAuthorship W3138285868A5073303207 @default.
- W3138285868 hasAuthorship W3138285868A5074920934 @default.
- W3138285868 hasConcept C104317684 @default.
- W3138285868 hasConcept C145059251 @default.
- W3138285868 hasConcept C1491633281 @default.
- W3138285868 hasConcept C170493617 @default.
- W3138285868 hasConcept C178790620 @default.
- W3138285868 hasConcept C185592680 @default.
- W3138285868 hasConcept C190283241 @default.
- W3138285868 hasConcept C2777209026 @default.
- W3138285868 hasConcept C2778024200 @default.
- W3138285868 hasConcept C2780827179 @default.
- W3138285868 hasConcept C2993711000 @default.
- W3138285868 hasConcept C502942594 @default.