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- W3138289039 abstract "Microtubules are dynamic polymers that play fundamental roles in all eukaryotes. Despite their importance, how new microtubules form is poorly understood. Textbooks have focused on variations of a nucleation-elongation mechanism in which monomers rapidly equilibrate with an unstable oligomer (nucleus) that limits the rate of polymer formation; once formed, the polymer then elongates efficiently from this nucleus by monomer addition. Such models faithfully describe actin assembly, but they fail to account for how more complex polymers like hollow microtubules assemble. Here, we articulate a new model for microtubule formation that has three key features: (1) microtubules initiate via rectangular, sheet-like structures that grow faster the larger they become; (2) the dominant pathway proceeds via accretion, the stepwise addition of longitudinal or lateral layers; and (3) a straightening penalty to account for the energetic cost of tubulin's curved-to-straight conformational transition. This model can quantitatively fit experimental assembly data, providing new insights into biochemical determinants and assembly pathways for microtubule nucleation." @default.
- W3138289039 created "2021-03-29" @default.
- W3138289039 creator A5038155883 @default.
- W3138289039 creator A5056334757 @default.
- W3138289039 creator A5081416783 @default.
- W3138289039 date "2021-03-18" @default.
- W3138289039 modified "2023-10-17" @default.
- W3138289039 title "Microtubules form by progressively faster tubulin accretion, not by nucleation–elongation" @default.
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- W3138289039 doi "https://doi.org/10.1083/jcb.202012079" @default.
- W3138289039 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7980253" @default.
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