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• W3138290124 abstract "Background: The mechanism of Interleukin-17 (IL-17) induced ventricular arrhythmia (VA) remains unclear. This study aimed to investigate the effect of intracellular calcium (Ca i ) handling and VA susceptibility by IL-17. Methods: The electrophysiological properties of isolated perfused rabbit hearts under IL-17 (20 ng/ml, N = 6) and the IL-17 with neutralizer (0.4 μg/ml, N = 6) were evaluated using an optical mapping system. The action potential duration (APD) and Ca i transient duration (Ca i TD) were examined, and semiquantitative reverse transcriptase-polymerase chain reaction analysis of ion channels was performed. Results: There were longer APD 80 , Ca i TD 80 and increased thresholds of APD and Ca i TD alternans, the maximum slope of APD restitution and induction of VA threshold in IL-17 group compared with those in IL-17 neutralizer and baseline groups. During ventricular fibrillation, the number of phase singularities and dominant frequency were both significantly greater in IL-17 group than in baseline group. The mRNA expressions of the Na + /Ca 2+ exchanger, phospholamban, and ryanodine receptor Ca 2+ release channel were upregulated, and the subunit of L-type Ca 2+ current and sarcoplasmic reticulum Ca 2+ -ATPase 2a were significantly reduced in IL-17 group compared to baseline and IL-17 neutralizer group. Conclusions: IL-17 enhanced Ca i TD and APD alternans through disturbances in calcium handling, which may increase VA susceptibility." @default.
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• W3138290124 date "2021-03-16" @default.
• W3138290124 modified "2023-10-15" @default.
• W3138290124 title "Proinflammatory Cytokine Modulates Intracellular Calcium Handling and Enhances Ventricular Arrhythmia Susceptibility" @default.
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• W3138290124 doi "https://doi.org/10.3389/fcvm.2021.623510" @default.
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