FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138310504> ?p ?o ?g. }

• W3138310504 endingPage "1144" @default.
• W3138310504 startingPage "1129" @default.
• W3138310504 abstract "Migraine is three times more common in women. CGRP plays a critical role in migraine pathology and causes female-specific behavioral responses upon meningeal application. These effects are likely mediated through interactions of CGRP with signaling systems specific to females. Prolactin (PRL) levels have been correlated with migraine attacks. Here, we explore a potential interaction between CGRP and PRL in the meninges.Prolactin, CGRP, and receptor antagonists CGRP8-37 or Δ1-9-G129R-hPRL were administered onto the dura of rodents followed by behavioral testing. Immunohistochemistry was used to examine PRL, CGRP and Prolactin receptor (Prlr) expression within the dura. Electrophysiology on cultured and back-labeled trigeminal ganglia (TG) neurons was used to assess PRL-induced excitability. Finally, the effects of PRL on evoked CGRP release from ex vivo dura were measured.We found that dural PRL produced sustained and long-lasting migraine-like behavior in cycling and ovariectomized female, but not male rodents. Prlr was expressed on dural afferent nerves in females with little-to-no presence in males. Consistent with this, PRL increased excitability only in female TG neurons innervating the dura and selectively sensitized CGRP release from female ex vivo dura. We demonstrate crosstalk between PRL and CGRP systems as CGRP8-37 decreases migraine-like responses to dural PRL. Reciprocally, Δ1-9-G129R-hPRL attenuates dural CGRP-induced migraine behaviors. Similarly, Prlr deletion from sensory neurons significantly reduced migraine-like responses to dural CGRP.This CGRP-PRL interaction in the meninges is a mechanism by which these peptides could produce female-selective responses and increase the prevalence of migraine in women. ANN NEUROL 2021;89:1129-1144." @default.
• W3138310504 created "2021-03-29" @default.
• W3138310504 creator A5014871799 @default.
• W3138310504 creator A5018096897 @default.
• W3138310504 creator A5020147685 @default.
• W3138310504 creator A5033043600 @default.
• W3138310504 creator A5035457610 @default.
• W3138310504 creator A5040294572 @default.
• W3138310504 creator A5041012326 @default.
• W3138310504 creator A5046482807 @default.
• W3138310504 creator A5047385433 @default.
• W3138310504 creator A5056024832 @default.
• W3138310504 creator A5066246489 @default.
• W3138310504 date "2021-04-22" @default.
• W3138310504 modified "2023-10-10" @default.
• W3138310504 title "Meningeal <scp>CGRP</scp> ‐Prolactin Interaction Evokes Female‐Specific Migraine Behavior" @default.
• W3138310504 cites W1512733937 @default.
• W3138310504 cites W1579104068 @default.
• W3138310504 cites W1605687369 @default.
• W3138310504 cites W1965498307 @default.
• W3138310504 cites W1975995948 @default.
• W3138310504 cites W1976187110 @default.
• W3138310504 cites W1976292966 @default.
• W3138310504 cites W1976505981 @default.
• W3138310504 cites W1979011028 @default.
• W3138310504 cites W1984560612 @default.
• W3138310504 cites W1985457113 @default.
• W3138310504 cites W1996846038 @default.
• W3138310504 cites W1999585523 @default.
• W3138310504 cites W1999892071 @default.
• W3138310504 cites W2016852812 @default.
• W3138310504 cites W2022662096 @default.
• W3138310504 cites W2030262806 @default.
• W3138310504 cites W2034407873 @default.
• W3138310504 cites W2035560305 @default.
• W3138310504 cites W2046951924 @default.
• W3138310504 cites W2048163077 @default.
• W3138310504 cites W2055352148 @default.
• W3138310504 cites W2055361854 @default.
• W3138310504 cites W2056146039 @default.
• W3138310504 cites W2059609797 @default.
• W3138310504 cites W2059935047 @default.
• W3138310504 cites W2069107563 @default.
• W3138310504 cites W2069296876 @default.
• W3138310504 cites W2072282199 @default.
• W3138310504 cites W2073785496 @default.
• W3138310504 cites W2088981463 @default.
• W3138310504 cites W2096813550 @default.
• W3138310504 cites W2104082801 @default.
• W3138310504 cites W2107259079 @default.
• W3138310504 cites W2110121007 @default.
• W3138310504 cites W2149592602 @default.
• W3138310504 cites W2158238437 @default.
• W3138310504 cites W2159543883 @default.
• W3138310504 cites W2161433208 @default.
• W3138310504 cites W2163775578 @default.
• W3138310504 cites W2164875032 @default.
• W3138310504 cites W2166688499 @default.
• W3138310504 cites W2168769379 @default.
• W3138310504 cites W2255740295 @default.
• W3138310504 cites W2295289350 @default.
• W3138310504 cites W2313661799 @default.
• W3138310504 cites W2407269195 @default.
• W3138310504 cites W2507140532 @default.
• W3138310504 cites W2518153053 @default.
• W3138310504 cites W2559478099 @default.
• W3138310504 cites W2788340920 @default.
• W3138310504 cites W2806358974 @default.
• W3138310504 cites W2912358317 @default.
• W3138310504 cites W2919814150 @default.
• W3138310504 cites W2929439854 @default.
• W3138310504 cites W2938393175 @default.
• W3138310504 cites W2955415153 @default.
• W3138310504 cites W2977306621 @default.
• W3138310504 doi "https://doi.org/10.1002/ana.26070" @default.
• W3138310504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8195469" @default.
• W3138310504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33749851" @default.
• W3138310504 hasPublicationYear "2021" @default.
• W3138310504 type Work @default.
• W3138310504 sameAs 3138310504 @default.
• W3138310504 citedByCount "38" @default.
• W3138310504 countsByYear W31383105042021 @default.
• W3138310504 countsByYear W31383105042022 @default.
• W3138310504 countsByYear W31383105042023 @default.
• W3138310504 crossrefType "journal-article" @default.
• W3138310504 hasAuthorship W3138310504A5014871799 @default.
• W3138310504 hasAuthorship W3138310504A5018096897 @default.
• W3138310504 hasAuthorship W3138310504A5020147685 @default.
• W3138310504 hasAuthorship W3138310504A5033043600 @default.
• W3138310504 hasAuthorship W3138310504A5035457610 @default.
• W3138310504 hasAuthorship W3138310504A5040294572 @default.
• W3138310504 hasAuthorship W3138310504A5041012326 @default.
• W3138310504 hasAuthorship W3138310504A5046482807 @default.
• W3138310504 hasAuthorship W3138310504A5047385433 @default.
• W3138310504 hasAuthorship W3138310504A5056024832 @default.
• W3138310504 hasAuthorship W3138310504A5066246489 @default.
• W3138310504 hasBestOaLocation W31383105043 @default.
• W3138310504 hasConcept C118303440 @default.

• next